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Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

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ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.


Functional connectivity between the PCC and parahippocampus. (A) Direct contrast between PTA patients and healthy controls. Results are overlaid on the MNI152 T1 1 mm brain template. (B) Graph representing functional connectivity (FC) values for the three experimental groups extracted from the parahippocampal brain area demonstrating significantly reduced functional connectivity in the direct contrast between PTA patients and healthy controls (HC). (C) Graph representing a significant correlation between PCC functional connectivity to the parahippocampus and scores on the PAL task. The colour bar represents P-values in the range of 0 to 0.05. L = left; R = right; TBIC = TBI controls.
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aww241-F5: Functional connectivity between the PCC and parahippocampus. (A) Direct contrast between PTA patients and healthy controls. Results are overlaid on the MNI152 T1 1 mm brain template. (B) Graph representing functional connectivity (FC) values for the three experimental groups extracted from the parahippocampal brain area demonstrating significantly reduced functional connectivity in the direct contrast between PTA patients and healthy controls (HC). (C) Graph representing a significant correlation between PCC functional connectivity to the parahippocampus and scores on the PAL task. The colour bar represents P-values in the range of 0 to 0.05. L = left; R = right; TBIC = TBI controls.

Mentions: We next specifically investigated the functional connectivity between the PCC and MTL structures (Fig. 5). At a voxel-wise level, functional connectivity between the PCC and parahippocampus was significantly reduced in the PTA group compared to the healthy control group (Fig. 5A and B). The region of reduced connectivity was located on the border of the anterior and posterior subdivisions of the left parahippocampus (Fig. 5A). TBI controls showed no difference in functional connectivity compared to healthy controls and there were no group differences in hippocampal functional connectivity at the voxel-wise level.Figure 5


Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia
Functional connectivity between the PCC and parahippocampus. (A) Direct contrast between PTA patients and healthy controls. Results are overlaid on the MNI152 T1 1 mm brain template. (B) Graph representing functional connectivity (FC) values for the three experimental groups extracted from the parahippocampal brain area demonstrating significantly reduced functional connectivity in the direct contrast between PTA patients and healthy controls (HC). (C) Graph representing a significant correlation between PCC functional connectivity to the parahippocampus and scores on the PAL task. The colour bar represents P-values in the range of 0 to 0.05. L = left; R = right; TBIC = TBI controls.
© Copyright Policy - cc-by
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5382939&req=5

aww241-F5: Functional connectivity between the PCC and parahippocampus. (A) Direct contrast between PTA patients and healthy controls. Results are overlaid on the MNI152 T1 1 mm brain template. (B) Graph representing functional connectivity (FC) values for the three experimental groups extracted from the parahippocampal brain area demonstrating significantly reduced functional connectivity in the direct contrast between PTA patients and healthy controls (HC). (C) Graph representing a significant correlation between PCC functional connectivity to the parahippocampus and scores on the PAL task. The colour bar represents P-values in the range of 0 to 0.05. L = left; R = right; TBIC = TBI controls.
Mentions: We next specifically investigated the functional connectivity between the PCC and MTL structures (Fig. 5). At a voxel-wise level, functional connectivity between the PCC and parahippocampus was significantly reduced in the PTA group compared to the healthy control group (Fig. 5A and B). The region of reduced connectivity was located on the border of the anterior and posterior subdivisions of the left parahippocampus (Fig. 5A). TBI controls showed no difference in functional connectivity compared to healthy controls and there were no group differences in hippocampal functional connectivity at the voxel-wise level.Figure 5

View Article: PubMed Central - PubMed

ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.