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Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

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ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.


Related in: MedlinePlus

Neuropsychological results for PTA patients compared to TBI and healthy control groups at follow-up. All tests are derived from the Cambridge Neuropsychological Test Automated Battery (CANTAB) computerized tool. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls; B = baseline; FU = follow-up; RT = reaction time.
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aww241-F3: Neuropsychological results for PTA patients compared to TBI and healthy control groups at follow-up. All tests are derived from the Cambridge Neuropsychological Test Automated Battery (CANTAB) computerized tool. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls; B = baseline; FU = follow-up; RT = reaction time.

Mentions: The PAL task was used to provide a sensitive measure of associative learning and memory (Fig. 1; see Supplementary material for a detailed description of the PAL task). A standardized neuropsychological battery was used to assess cognitive function more generally. Six tasks from the CANTAB computerized tool were completed. In addition to the PAL, tasks completed consisted of the Choice Reaction Time (CRT) task to assess information-processing speed and sustained attention, the Spatial Working Memory (SWM) task, the Spatial Recognition Memory (SRM) task, the Pattern Recognition Memory task (PRM) task and the Verbal Recognition Memory (VRM) task. A description of the specific outcome measures used for the different tasks can be found in Figs 2 and 3 and Supplementary Table 3. One-way ANOVAs were run to identify group effects at baseline. Post hoc independent sample t-tests (Welch’s two-sample t-test) were performed to determine which pairwise comparisons were driving any significant main effects identified. Linear mixed-effects models were used to assess longitudinal changes between baseline and follow-up. Group and time point were defined as fixed effects, whereas subject was defined as a random effect to model variability in subject intercepts. Post hoc paired sample t-tests were used to investigate any significant main effects or interactions. Follow-up analyses were not performed on the VRM and PRM tasks for PTA patients due to insufficient data points. All statistical analysis was performed using R (v0.98.1091).Figure 2


Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia
Neuropsychological results for PTA patients compared to TBI and healthy control groups at follow-up. All tests are derived from the Cambridge Neuropsychological Test Automated Battery (CANTAB) computerized tool. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls; B = baseline; FU = follow-up; RT = reaction time.
© Copyright Policy - cc-by
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5382939&req=5

aww241-F3: Neuropsychological results for PTA patients compared to TBI and healthy control groups at follow-up. All tests are derived from the Cambridge Neuropsychological Test Automated Battery (CANTAB) computerized tool. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls; B = baseline; FU = follow-up; RT = reaction time.
Mentions: The PAL task was used to provide a sensitive measure of associative learning and memory (Fig. 1; see Supplementary material for a detailed description of the PAL task). A standardized neuropsychological battery was used to assess cognitive function more generally. Six tasks from the CANTAB computerized tool were completed. In addition to the PAL, tasks completed consisted of the Choice Reaction Time (CRT) task to assess information-processing speed and sustained attention, the Spatial Working Memory (SWM) task, the Spatial Recognition Memory (SRM) task, the Pattern Recognition Memory task (PRM) task and the Verbal Recognition Memory (VRM) task. A description of the specific outcome measures used for the different tasks can be found in Figs 2 and 3 and Supplementary Table 3. One-way ANOVAs were run to identify group effects at baseline. Post hoc independent sample t-tests (Welch’s two-sample t-test) were performed to determine which pairwise comparisons were driving any significant main effects identified. Linear mixed-effects models were used to assess longitudinal changes between baseline and follow-up. Group and time point were defined as fixed effects, whereas subject was defined as a random effect to model variability in subject intercepts. Post hoc paired sample t-tests were used to investigate any significant main effects or interactions. Follow-up analyses were not performed on the VRM and PRM tasks for PTA patients due to insufficient data points. All statistical analysis was performed using R (v0.98.1091).Figure 2

View Article: PubMed Central - PubMed

ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.


Related in: MedlinePlus