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Production and physiological role of NO in the oral cavity

View Article: PubMed Central - PubMed

ABSTRACT

Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synthase (NOS), which has three identified isoforms: neuronal type NOS (nNOS), endothelial type NOS (eNOS), and inducible type NOS (iNOS). Different isoforms are expressed depending on the organs, tissues, and cells, and investigation of the types and functions of enzymes expressed in various tissues is underway. The oral cavity is a space in which marked changes have been detected in NO levels, and each tissue is constantly influenced by NO. NO is a component of saliva and is produced by oral bacteria in the oral cavity and released by NOS expressed in oral mucosa. NOS isoforms expressed under normal conditions differ among the oral organs. In addition, the overexpression of NOS was involved in carcinogenesis and tumor growth progression. This review summarized the expression of NOS and functions of NO in oral cavity organs, and their roles in diseases and the influences of treatments.

No MeSH data available.


Expression of eNOS mRNA in the mouse lower incisor at 8 weeks of age by in situ hybridization. eNOS signals are detected in ameloblasts (arrow) at the maturation stage (asterisk: enamel). Bar, 50 μm.
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fig0010: Expression of eNOS mRNA in the mouse lower incisor at 8 weeks of age by in situ hybridization. eNOS signals are detected in ameloblasts (arrow) at the maturation stage (asterisk: enamel). Bar, 50 μm.

Mentions: Few studies have investigated the role of NOS expression in odontogenesis. A neonatal mouse tooth germ was cultured and the influence of NO was investigated, and the findings obtained suggested that a NO signaling pathway was partially involved in the amelogenin production process in ameloblasts [43]. Our group also investigated the function and expression of NOS in ameloblasts at the protein and mRNA levels using a mouse tooth germ. We confirmed the mRNA expression of iNOS and eNOS in ameloblasts in the maturation stage using in situ hybridization, showing that NO was produced by iNOS and eNOS in maturation-stage ameloblasts (Fig. 2). The function of this NO is now being investigated. We assume that it is involved in secondary calcification and protein removal by ameloblasts.


Production and physiological role of NO in the oral cavity
Expression of eNOS mRNA in the mouse lower incisor at 8 weeks of age by in situ hybridization. eNOS signals are detected in ameloblasts (arrow) at the maturation stage (asterisk: enamel). Bar, 50 μm.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5382787&req=5

fig0010: Expression of eNOS mRNA in the mouse lower incisor at 8 weeks of age by in situ hybridization. eNOS signals are detected in ameloblasts (arrow) at the maturation stage (asterisk: enamel). Bar, 50 μm.
Mentions: Few studies have investigated the role of NOS expression in odontogenesis. A neonatal mouse tooth germ was cultured and the influence of NO was investigated, and the findings obtained suggested that a NO signaling pathway was partially involved in the amelogenin production process in ameloblasts [43]. Our group also investigated the function and expression of NOS in ameloblasts at the protein and mRNA levels using a mouse tooth germ. We confirmed the mRNA expression of iNOS and eNOS in ameloblasts in the maturation stage using in situ hybridization, showing that NO was produced by iNOS and eNOS in maturation-stage ameloblasts (Fig. 2). The function of this NO is now being investigated. We assume that it is involved in secondary calcification and protein removal by ameloblasts.

View Article: PubMed Central - PubMed

ABSTRACT

Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synthase (NOS), which has three identified isoforms: neuronal type NOS (nNOS), endothelial type NOS (eNOS), and inducible type NOS (iNOS). Different isoforms are expressed depending on the organs, tissues, and cells, and investigation of the types and functions of enzymes expressed in various tissues is underway. The oral cavity is a space in which marked changes have been detected in NO levels, and each tissue is constantly influenced by NO. NO is a component of saliva and is produced by oral bacteria in the oral cavity and released by NOS expressed in oral mucosa. NOS isoforms expressed under normal conditions differ among the oral organs. In addition, the overexpression of NOS was involved in carcinogenesis and tumor growth progression. This review summarized the expression of NOS and functions of NO in oral cavity organs, and their roles in diseases and the influences of treatments.

No MeSH data available.