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Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA

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ABSTRACT

Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005–2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000). Japanese patients were twice as likely as all other racial/ethnic groups to have Mycobacterium abscessus isolated (adjusted odds ratio 2.0, 95% CI 1.2–3.2) but were not at increased risk for infection with other mycobacteria species. In contrast, incidence of TB was stable and was lowest among Japanese patients (no cases) and highest among Filipino, Korean, and Vietnamese patients (>50/100,000). Substantial differences exist in the epidemiology of NTMPD by race/ethnicity, suggesting behavioral and biologic factors that affect disease susceptibility.

No MeSH data available.


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Overall period prevalence of pulmonary nontuberculous mycobacteria isolation, by race/ethnicity and age group, among a cohort of Kaiser Permanente Hawaii patients, Hawaii, 2005–2013. No cases of nontuberculous mycobacteria isolation were reported among Vietnamese patients >65 years of age. NHOPI, Native Hawaiians and Other Pacific Islanders.
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Figure 5: Overall period prevalence of pulmonary nontuberculous mycobacteria isolation, by race/ethnicity and age group, among a cohort of Kaiser Permanente Hawaii patients, Hawaii, 2005–2013. No cases of nontuberculous mycobacteria isolation were reported among Vietnamese patients >65 years of age. NHOPI, Native Hawaiians and Other Pacific Islanders.

Mentions: NTM isolation period prevalence was highest among Japanese, Chinese, Korean, and Vietnamese patients (≈300 cases/100,000 persons; average annual prevalence 34 cases/100,000 persons), similar among Filipino and white patients (162 and 156 cases/100,000 persons, respectively; average annual prevalence 18 cases/100,000 persons), and lowest among NHOPI patients (50 cases/100,000 persons; average annual prevalence 6 cases/100,000 persons) (Figures 4, 5). NTM isolation prevalence was progressively greater by increasing age group across nearly all racial/ethnic groups evaluated (Figure 5). Among Vietnamese and Korean patients, the highest NTM isolation rates were observed among those 50–64 years of age (767 and 823 cases/100,000 persons, respectively); however, these estimates did not significantly differ from those observed among persons >65 years of age in these populations (p>0.2). Sex differences in NTM isolation prevalence were also noted by racial/ethnic group (Figure 6). Among Vietnamese patients, NTM isolation was more prevalent among men than women (568 vs. 105 cases/100,000 persons), whereas among Japanese patients, NTM isolation was more prevalent among women than men (378 vs. 287 cases/100,000 persons). For all other racial/ethnic groups, prevalence did not differ greatly by sex. NTM isolation prevalence was consistently double the NTMPD prevalence.


Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA
Overall period prevalence of pulmonary nontuberculous mycobacteria isolation, by race/ethnicity and age group, among a cohort of Kaiser Permanente Hawaii patients, Hawaii, 2005–2013. No cases of nontuberculous mycobacteria isolation were reported among Vietnamese patients >65 years of age. NHOPI, Native Hawaiians and Other Pacific Islanders.
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Related In: Results  -  Collection

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Figure 5: Overall period prevalence of pulmonary nontuberculous mycobacteria isolation, by race/ethnicity and age group, among a cohort of Kaiser Permanente Hawaii patients, Hawaii, 2005–2013. No cases of nontuberculous mycobacteria isolation were reported among Vietnamese patients >65 years of age. NHOPI, Native Hawaiians and Other Pacific Islanders.
Mentions: NTM isolation period prevalence was highest among Japanese, Chinese, Korean, and Vietnamese patients (≈300 cases/100,000 persons; average annual prevalence 34 cases/100,000 persons), similar among Filipino and white patients (162 and 156 cases/100,000 persons, respectively; average annual prevalence 18 cases/100,000 persons), and lowest among NHOPI patients (50 cases/100,000 persons; average annual prevalence 6 cases/100,000 persons) (Figures 4, 5). NTM isolation prevalence was progressively greater by increasing age group across nearly all racial/ethnic groups evaluated (Figure 5). Among Vietnamese and Korean patients, the highest NTM isolation rates were observed among those 50–64 years of age (767 and 823 cases/100,000 persons, respectively); however, these estimates did not significantly differ from those observed among persons >65 years of age in these populations (p>0.2). Sex differences in NTM isolation prevalence were also noted by racial/ethnic group (Figure 6). Among Vietnamese patients, NTM isolation was more prevalent among men than women (568 vs. 105 cases/100,000 persons), whereas among Japanese patients, NTM isolation was more prevalent among women than men (378 vs. 287 cases/100,000 persons). For all other racial/ethnic groups, prevalence did not differ greatly by sex. NTM isolation prevalence was consistently double the NTMPD prevalence.

View Article: PubMed Central - PubMed

ABSTRACT

Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005–2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000). Japanese patients were twice as likely as all other racial/ethnic groups to have Mycobacterium abscessus isolated (adjusted odds ratio 2.0, 95% CI 1.2–3.2) but were not at increased risk for infection with other mycobacteria species. In contrast, incidence of TB was stable and was lowest among Japanese patients (no cases) and highest among Filipino, Korean, and Vietnamese patients (>50/100,000). Substantial differences exist in the epidemiology of NTMPD by race/ethnicity, suggesting behavioral and biologic factors that affect disease susceptibility.

No MeSH data available.


Related in: MedlinePlus