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Molecular, Spatial, and Field Epidemiology Suggesting TB Transmission in Community, Not Hospital, Gaborone, Botswana

View Article: PubMed Central - PubMed

ABSTRACT

During 2012–2015, 10 of 24 patients infected with matching genotypes of Mycobacterium tuberculosis received care at the same hospital in Gaborone, Botswana. Nosocomial transmission was initially suspected, but we discovered plausible sites of community transmission for 20 (95%) of 21 interviewed patients. Active case-finding at these sites could halt ongoing transmission.

No MeSH data available.


Related in: MedlinePlus

Timing of hospital visits and treatment for 10 tuberculosis (TB) cluster–associated patients, Gaborone, Botswana, 2013–2015. Patients were hospitalized or seen in the accident and emergency ward, and all had a history of such visits since 2004. Visits prior to October 2013 are not shown; these include visits in 2012 by patients A and I and additional visits by patients N, T, and U. None of the pre-October 2013 visits overlapped with those of other TB cluster–associated patients.
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Figure 1: Timing of hospital visits and treatment for 10 tuberculosis (TB) cluster–associated patients, Gaborone, Botswana, 2013–2015. Patients were hospitalized or seen in the accident and emergency ward, and all had a history of such visits since 2004. Visits prior to October 2013 are not shown; these include visits in 2012 by patients A and I and additional visits by patients N, T, and U. None of the pre-October 2013 visits overlapped with those of other TB cluster–associated patients.

Mentions: All patients had pulmonary disease involvement (Table 1). Ten (42%) had received care at the hospital since 2004; most visits occurred after October 2013 (Figure 1). Except for visits by 2 patients, no patients’ visits overlapped at the hospital. Patients V and X overlapped in the hospital for 3 days, albeit in separate buildings. Patient V was admitted to the hospital with a known diagnosis of TB and had started TB therapy the day before admission. Patient X was in the hospital for a week but did not start TB therapy until 13 days after patient V was admitted. No members of this cluster were healthcare workers.


Molecular, Spatial, and Field Epidemiology Suggesting TB Transmission in Community, Not Hospital, Gaborone, Botswana
Timing of hospital visits and treatment for 10 tuberculosis (TB) cluster–associated patients, Gaborone, Botswana, 2013–2015. Patients were hospitalized or seen in the accident and emergency ward, and all had a history of such visits since 2004. Visits prior to October 2013 are not shown; these include visits in 2012 by patients A and I and additional visits by patients N, T, and U. None of the pre-October 2013 visits overlapped with those of other TB cluster–associated patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5382725&req=5

Figure 1: Timing of hospital visits and treatment for 10 tuberculosis (TB) cluster–associated patients, Gaborone, Botswana, 2013–2015. Patients were hospitalized or seen in the accident and emergency ward, and all had a history of such visits since 2004. Visits prior to October 2013 are not shown; these include visits in 2012 by patients A and I and additional visits by patients N, T, and U. None of the pre-October 2013 visits overlapped with those of other TB cluster–associated patients.
Mentions: All patients had pulmonary disease involvement (Table 1). Ten (42%) had received care at the hospital since 2004; most visits occurred after October 2013 (Figure 1). Except for visits by 2 patients, no patients’ visits overlapped at the hospital. Patients V and X overlapped in the hospital for 3 days, albeit in separate buildings. Patient V was admitted to the hospital with a known diagnosis of TB and had started TB therapy the day before admission. Patient X was in the hospital for a week but did not start TB therapy until 13 days after patient V was admitted. No members of this cluster were healthcare workers.

View Article: PubMed Central - PubMed

ABSTRACT

During 2012–2015, 10 of 24 patients infected with matching genotypes of Mycobacterium tuberculosis received care at the same hospital in Gaborone, Botswana. Nosocomial transmission was initially suspected, but we discovered plausible sites of community transmission for 20 (95%) of 21 interviewed patients. Active case-finding at these sites could halt ongoing transmission.

No MeSH data available.


Related in: MedlinePlus