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High transition frequencies of dynamic functional connectivity states in the creative brain

View Article: PubMed Central - PubMed

ABSTRACT

Creativity is thought to require the flexible reconfiguration of multiple brain regions that interact in transient and complex communication patterns. In contrast to prior emphases on searching for specific regions or networks associated with creative performance, we focused on exploring the association between the reconfiguration of dynamic functional connectivity states and creative ability. We hypothesized that a high frequency of dynamic functional connectivity state transitions will be associated with creative ability. To test this hypothesis, we recruited a high-creative group (HCG) and a low-creative group (LCG) of participants and collected resting-state fMRI (R-fMRI) data and Torrance Tests of Creative Thinking (TTCT) scores from each participant. By combining an independent component analysis with a dynamic network analysis approach, we discovered the HCG had more frequent transitions between dynamic functional connectivity (dFC) states than the LCG. Moreover, a confirmatory analysis using multiplication of temporal derivatives also indicated that there were more frequent dFC state transitions in the HCG. Taken together, these results provided empirical evidence for a linkage between the flexible reconfiguration of dynamic functional connectivity states and creative ability. These findings have the potential to provide new insights into the neural basis of creativity.

No MeSH data available.


Hub structures of dynamic functional connectivity states.The nodes with the same color are assigned to the same module. The size of the nodes indicates their role: the largest are connector hubs, the smaller are provincial hubs, and the smallest are non-hub nodes.
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f5: Hub structures of dynamic functional connectivity states.The nodes with the same color are assigned to the same module. The size of the nodes indicates their role: the largest are connector hubs, the smaller are provincial hubs, and the smallest are non-hub nodes.

Mentions: To have a better understanding of the characteristics of the dFC states, we estimated the hub structures, which play a pivotal role in the organization of the overall networks, for each of the dFC states35. Figure 5 shows the hub structures of the four dFC states, and Table 3 lists all the modular hubs of each dFC state. Briefly, the hubs of state 1 were primarily located in the CCN, SMN and VSN, of these, three nodes in the CCN (inferior frontal gyrus, IFG; superior frontal gyrus, SFG; and middle frontal gyrus, MiFG) were connector hubs. The hubs of state 2 were scattered in the CCN, SMN, DMN and VSN, of these, the SFG in the CCN and the supra-marginal gyrus (SMG) in the SMN were connector hubs. The hubs of state 3 were located in the SMN and DMN, of these the SMG in the SMN was connector hub. Most of the hubs of state 4 were located in the DMN, and three nodes in the DMN (posterior cingulate cortex, PCC; anterior cingulate cortex, ACC; and angular gyrus, AG) and SFG in CCN were connector hubs.


High transition frequencies of dynamic functional connectivity states in the creative brain
Hub structures of dynamic functional connectivity states.The nodes with the same color are assigned to the same module. The size of the nodes indicates their role: the largest are connector hubs, the smaller are provincial hubs, and the smallest are non-hub nodes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5382673&req=5

f5: Hub structures of dynamic functional connectivity states.The nodes with the same color are assigned to the same module. The size of the nodes indicates their role: the largest are connector hubs, the smaller are provincial hubs, and the smallest are non-hub nodes.
Mentions: To have a better understanding of the characteristics of the dFC states, we estimated the hub structures, which play a pivotal role in the organization of the overall networks, for each of the dFC states35. Figure 5 shows the hub structures of the four dFC states, and Table 3 lists all the modular hubs of each dFC state. Briefly, the hubs of state 1 were primarily located in the CCN, SMN and VSN, of these, three nodes in the CCN (inferior frontal gyrus, IFG; superior frontal gyrus, SFG; and middle frontal gyrus, MiFG) were connector hubs. The hubs of state 2 were scattered in the CCN, SMN, DMN and VSN, of these, the SFG in the CCN and the supra-marginal gyrus (SMG) in the SMN were connector hubs. The hubs of state 3 were located in the SMN and DMN, of these the SMG in the SMN was connector hub. Most of the hubs of state 4 were located in the DMN, and three nodes in the DMN (posterior cingulate cortex, PCC; anterior cingulate cortex, ACC; and angular gyrus, AG) and SFG in CCN were connector hubs.

View Article: PubMed Central - PubMed

ABSTRACT

Creativity is thought to require the flexible reconfiguration of multiple brain regions that interact in transient and complex communication patterns. In contrast to prior emphases on searching for specific regions or networks associated with creative performance, we focused on exploring the association between the reconfiguration of dynamic functional connectivity states and creative ability. We hypothesized that a high frequency of dynamic functional connectivity state transitions will be associated with creative ability. To test this hypothesis, we recruited a high-creative group (HCG) and a low-creative group (LCG) of participants and collected resting-state fMRI (R-fMRI) data and Torrance Tests of Creative Thinking (TTCT) scores from each participant. By combining an independent component analysis with a dynamic network analysis approach, we discovered the HCG had more frequent transitions between dynamic functional connectivity (dFC) states than the LCG. Moreover, a confirmatory analysis using multiplication of temporal derivatives also indicated that there were more frequent dFC state transitions in the HCG. Taken together, these results provided empirical evidence for a linkage between the flexible reconfiguration of dynamic functional connectivity states and creative ability. These findings have the potential to provide new insights into the neural basis of creativity.

No MeSH data available.