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Field efficacy of Porcilis ® PCV M Hyo versus a licensed commercially available vaccine and placebo in the prevention of PRDC in pigs on a French farm: a randomized controlled trial

View Article: PubMed Central - PubMed

ABSTRACT

Background: A controlled, randomised, and blinded trial performed on a conventional French farrow-to-finish farm compared the efficacy of a one-shot bivalent ready to use vaccine, Porcilis® PCV M. Hyo (group PCVM), to that of two commercial vaccines (Ingelvac® Circoflex® + Ingelvac® Mhyo, group ICIM), and to a placebo (group CTL), in preventing the health and economic impacts of Porcine Respiratory Disease Complex (PRDC).

Material & methods: In this small-scale clinical study, all piglets in each group were administered the vaccine/placebo at weaning age (27 days old). Piglets from either of the three groups were bled at regular intervals from 3 weeks of age until slaughter, in order to assess the infection by the main PRDC infectious agents: Mycoplasma hyopneumoniae, PCV2 and PRRSV. Performance, lung checks and slaughter data were collected and analysed.

Results: PCV2 viremia was significantly reduced in both vaccinated groups as compared to the placebo group. Lung lesion score was significantly lower in group PCVM, as compared to groups CTL and ICIM. Average daily weight gain during the finishing period was not significantly different between both vaccinated groups and was significantly higher than in the placebo group (849 g/d in the latter). Carcass results provided a numerical advantage to PCVM group, through improved part of production eligible for premium payment, and superior farmer income; this was a trend and did not reach significance.

Conclusion: The one-shot bivalent vaccine Porcilis® PCV M Hyo proved to be efficacious and convenient to use in a field context of active PCV2 and M. hyopneumoniae infections.

No MeSH data available.


Related in: MedlinePlus

Percentage of pigs with pneumonia, in each trial group, in a subset of 179 pigs, from the 498 pigs included
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Fig3: Percentage of pigs with pneumonia, in each trial group, in a subset of 179 pigs, from the 498 pigs included

Mentions: Lung scoring was performed individually according to the method established by Goodwin [9]. The mean lung lesion score of group PCVM was found to be lower, with a significant difference (p = 0.007, Kruskal-Wallis test, see Fig. 2), compared with the 2 other groups. Also, the proportion of lungs with pneumonic lesions was significantly higher in both group CTL and group ICIM, as compared to group PCVM (p = 0.021, Pearson Chi-square, see Fig. 3). Taken together, these results are in favour of the use of multivalent vaccines/vaccine programmes in prevention of PRDC. Under the condition that the selected valences are adapted to the local combination of the pathogens implied in PRDC, this trial adds-up to the growing body of evidence of the efficacy of this intervention, as has recently been demonstrated in Germany [10] against PCV2 and M. hyopneumoniae or Korea [11] against PCV2 and PRRSV, with a more limited number of primary parameters.Fig. 2


Field efficacy of Porcilis ® PCV M Hyo versus a licensed commercially available vaccine and placebo in the prevention of PRDC in pigs on a French farm: a randomized controlled trial
Percentage of pigs with pneumonia, in each trial group, in a subset of 179 pigs, from the 498 pigs included
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5382521&req=5

Fig3: Percentage of pigs with pneumonia, in each trial group, in a subset of 179 pigs, from the 498 pigs included
Mentions: Lung scoring was performed individually according to the method established by Goodwin [9]. The mean lung lesion score of group PCVM was found to be lower, with a significant difference (p = 0.007, Kruskal-Wallis test, see Fig. 2), compared with the 2 other groups. Also, the proportion of lungs with pneumonic lesions was significantly higher in both group CTL and group ICIM, as compared to group PCVM (p = 0.021, Pearson Chi-square, see Fig. 3). Taken together, these results are in favour of the use of multivalent vaccines/vaccine programmes in prevention of PRDC. Under the condition that the selected valences are adapted to the local combination of the pathogens implied in PRDC, this trial adds-up to the growing body of evidence of the efficacy of this intervention, as has recently been demonstrated in Germany [10] against PCV2 and M. hyopneumoniae or Korea [11] against PCV2 and PRRSV, with a more limited number of primary parameters.Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: A controlled, randomised, and blinded trial performed on a conventional French farrow-to-finish farm compared the efficacy of a one-shot bivalent ready to use vaccine, Porcilis® PCV M. Hyo (group PCVM), to that of two commercial vaccines (Ingelvac® Circoflex® + Ingelvac® Mhyo, group ICIM), and to a placebo (group CTL), in preventing the health and economic impacts of Porcine Respiratory Disease Complex (PRDC).

Material & methods: In this small-scale clinical study, all piglets in each group were administered the vaccine/placebo at weaning age (27 days old). Piglets from either of the three groups were bled at regular intervals from 3 weeks of age until slaughter, in order to assess the infection by the main PRDC infectious agents: Mycoplasma hyopneumoniae, PCV2 and PRRSV. Performance, lung checks and slaughter data were collected and analysed.

Results: PCV2 viremia was significantly reduced in both vaccinated groups as compared to the placebo group. Lung lesion score was significantly lower in group PCVM, as compared to groups CTL and ICIM. Average daily weight gain during the finishing period was not significantly different between both vaccinated groups and was significantly higher than in the placebo group (849 g/d in the latter). Carcass results provided a numerical advantage to PCVM group, through improved part of production eligible for premium payment, and superior farmer income; this was a trend and did not reach significance.

Conclusion: The one-shot bivalent vaccine Porcilis® PCV M Hyo proved to be efficacious and convenient to use in a field context of active PCV2 and M. hyopneumoniae infections.

No MeSH data available.


Related in: MedlinePlus