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Modified-live PRRSV subtype 1 vaccine UNISTRAIN ® PRRS provides a partial clinical and virological protection upon challenge with East European subtype 3 PRRSV strain Lena

View Article: PubMed Central - PubMed

ABSTRACT

Background: Western European porcine reproductive and respiratory syndrome virus (PRRSV) strains cause limited and mild clinical signs whereas more virulent strains are circulating in Eastern Europe. The emergence of such highly virulent strains in Western Europe might result in severe clinical problems and a financial disaster. In this context, the efficacy of the commercial modified-live PRRSV subtype 1 vaccine UNISTRAIN® PRRS was tested upon challenge with the East European subtype 3 PRRSV strain Lena.

Results: The mean duration of fever was shortened and the number of fever days was significantly lower in vaccinated pigs than in control pigs. Moreover, a lower number of vaccinated animals showed fever, respiratory disorders and conjunctivitis. The mean virus titers in the nasal secretions post challenge (AUC) were significantly lower in the vaccinated group than in the control group. The duration of viremia was slightly shorter (not significantly different) in the vaccinated group as compared to the control group.

Conclusions: Vaccination of pigs with the modified-live vaccine UNISTRAIN® PRRS provides a partial clinical and virological protection against the PRRSV subtype 3 strain Lena.

No MeSH data available.


Related in: MedlinePlus

Viremia after challenge with PRRSV subtype 3 strain Lena. Bullets represent individual animals; lines represent the mean titer in each group. Solid bullets and solid line show the titer for the control group; open bullets and dashed line show the titer for the vaccinated group. Dotted line represents the detection limit for the test
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Fig5: Viremia after challenge with PRRSV subtype 3 strain Lena. Bullets represent individual animals; lines represent the mean titer in each group. Solid bullets and solid line show the titer for the control group; open bullets and dashed line show the titer for the vaccinated group. Dotted line represents the detection limit for the test

Mentions: The results of virus titrations of sera (viremia) are shown in Fig. 5. Virus was present in sera of all animals from 3 dpc. A peak was observed at 10 dpc in the control group (4.2 ± 0.2 log10 TCID50/ml) and at 5 dpc in the vaccinated group (4.7 ± 0.6 log10 TCID50/ml). In the control group, viremia lasted until at least 28 dpc (end of the experiment) with two out of six piglets still being viremic, although at low titers (2.1 and 1.6 log10 TCID50/ml). In the vaccinated group, viremia lasted until 21 dpc. Despite the shorter duration of viremia, no significant differences were observed in the mean virus titer between control and vaccinated pigs. Also, no significant differences were seen for AUC values between both groups (15.4 ± 0.8 in control animals versus 15.9 ± 2.0 in vaccinated animals).Fig. 5


Modified-live PRRSV subtype 1 vaccine UNISTRAIN ® PRRS provides a partial clinical and virological protection upon challenge with East European subtype 3 PRRSV strain Lena
Viremia after challenge with PRRSV subtype 3 strain Lena. Bullets represent individual animals; lines represent the mean titer in each group. Solid bullets and solid line show the titer for the control group; open bullets and dashed line show the titer for the vaccinated group. Dotted line represents the detection limit for the test
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5382438&req=5

Fig5: Viremia after challenge with PRRSV subtype 3 strain Lena. Bullets represent individual animals; lines represent the mean titer in each group. Solid bullets and solid line show the titer for the control group; open bullets and dashed line show the titer for the vaccinated group. Dotted line represents the detection limit for the test
Mentions: The results of virus titrations of sera (viremia) are shown in Fig. 5. Virus was present in sera of all animals from 3 dpc. A peak was observed at 10 dpc in the control group (4.2 ± 0.2 log10 TCID50/ml) and at 5 dpc in the vaccinated group (4.7 ± 0.6 log10 TCID50/ml). In the control group, viremia lasted until at least 28 dpc (end of the experiment) with two out of six piglets still being viremic, although at low titers (2.1 and 1.6 log10 TCID50/ml). In the vaccinated group, viremia lasted until 21 dpc. Despite the shorter duration of viremia, no significant differences were observed in the mean virus titer between control and vaccinated pigs. Also, no significant differences were seen for AUC values between both groups (15.4 ± 0.8 in control animals versus 15.9 ± 2.0 in vaccinated animals).Fig. 5

View Article: PubMed Central - PubMed

ABSTRACT

Background: Western European porcine reproductive and respiratory syndrome virus (PRRSV) strains cause limited and mild clinical signs whereas more virulent strains are circulating in Eastern Europe. The emergence of such highly virulent strains in Western Europe might result in severe clinical problems and a financial disaster. In this context, the efficacy of the commercial modified-live PRRSV subtype 1 vaccine UNISTRAIN® PRRS was tested upon challenge with the East European subtype 3 PRRSV strain Lena.

Results: The mean duration of fever was shortened and the number of fever days was significantly lower in vaccinated pigs than in control pigs. Moreover, a lower number of vaccinated animals showed fever, respiratory disorders and conjunctivitis. The mean virus titers in the nasal secretions post challenge (AUC) were significantly lower in the vaccinated group than in the control group. The duration of viremia was slightly shorter (not significantly different) in the vaccinated group as compared to the control group.

Conclusions: Vaccination of pigs with the modified-live vaccine UNISTRAIN® PRRS provides a partial clinical and virological protection against the PRRSV subtype 3 strain Lena.

No MeSH data available.


Related in: MedlinePlus