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Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect

View Article: PubMed Central - PubMed

ABSTRACT

Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed. Results. All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR. Conclusion. MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

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Related in: MedlinePlus

Relationships between mean blur rate in all areas (MBRA), total deviation (TD), macular ganglion cell complex (mGCC) thickness, and circumpapillary retinal nerve fiber layer (cpRNFL) thickness corresponding to the defective hemifield: (a) MBRA and TD, y = 15.984 + 5.232x (r = 0.352, P = 0.015); (b) MBRA and mGCC thickness, y = 5.796 + 0.165x (r = 0.293, P = 0.046); (c) MBRA and cpRNFL thickness y = 6.347 + 0.160x (r = 0.299, P = 0.041).
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fig3: Relationships between mean blur rate in all areas (MBRA), total deviation (TD), macular ganglion cell complex (mGCC) thickness, and circumpapillary retinal nerve fiber layer (cpRNFL) thickness corresponding to the defective hemifield: (a) MBRA and TD, y = 15.984 + 5.232x (r = 0.352, P = 0.015); (b) MBRA and mGCC thickness, y = 5.796 + 0.165x (r = 0.293, P = 0.046); (c) MBRA and cpRNFL thickness y = 6.347 + 0.160x (r = 0.299, P = 0.041).

Mentions: Figure 3 shows the relationships between MBRA, TD, mGCC thickness, and cpRNFL thickness corresponding to the defective hemifield. In the defective hemifield, MBRA was correlated with TD (r = 0.352, P = 0.015), mGCC thickness (r = 0.293, P = 0.046), and cpRNFL thickness (r = 0.299, P = 0.041). While MBRv was also correlated with TD (r = 0.302, P = 0.039), MBRT was not (r = 0.212, P = 0.152). Regarding OCT measurements, TD was correlated with both mGCC thickness (r = 0.363, P = 0.012) and cpRNFL thickness (r = 0.383, P = 0.008). The multiple regression analysis, wherein MBRA was used as the dependent variable and TD, mGCC thickness, and cpRNFL thickness were used as explanatory variables, showed that TD was a significant contributing factor (slope 5.232, 95% confidence interval [CI] = 1.062–9.402, and P = 0.015) of the MBRA.


Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect
Relationships between mean blur rate in all areas (MBRA), total deviation (TD), macular ganglion cell complex (mGCC) thickness, and circumpapillary retinal nerve fiber layer (cpRNFL) thickness corresponding to the defective hemifield: (a) MBRA and TD, y = 15.984 + 5.232x (r = 0.352, P = 0.015); (b) MBRA and mGCC thickness, y = 5.796 + 0.165x (r = 0.293, P = 0.046); (c) MBRA and cpRNFL thickness y = 6.347 + 0.160x (r = 0.299, P = 0.041).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5382394&req=5

fig3: Relationships between mean blur rate in all areas (MBRA), total deviation (TD), macular ganglion cell complex (mGCC) thickness, and circumpapillary retinal nerve fiber layer (cpRNFL) thickness corresponding to the defective hemifield: (a) MBRA and TD, y = 15.984 + 5.232x (r = 0.352, P = 0.015); (b) MBRA and mGCC thickness, y = 5.796 + 0.165x (r = 0.293, P = 0.046); (c) MBRA and cpRNFL thickness y = 6.347 + 0.160x (r = 0.299, P = 0.041).
Mentions: Figure 3 shows the relationships between MBRA, TD, mGCC thickness, and cpRNFL thickness corresponding to the defective hemifield. In the defective hemifield, MBRA was correlated with TD (r = 0.352, P = 0.015), mGCC thickness (r = 0.293, P = 0.046), and cpRNFL thickness (r = 0.299, P = 0.041). While MBRv was also correlated with TD (r = 0.302, P = 0.039), MBRT was not (r = 0.212, P = 0.152). Regarding OCT measurements, TD was correlated with both mGCC thickness (r = 0.363, P = 0.012) and cpRNFL thickness (r = 0.383, P = 0.008). The multiple regression analysis, wherein MBRA was used as the dependent variable and TD, mGCC thickness, and cpRNFL thickness were used as explanatory variables, showed that TD was a significant contributing factor (slope 5.232, 95% confidence interval [CI] = 1.062–9.402, and P = 0.015) of the MBRA.

View Article: PubMed Central - PubMed

ABSTRACT

Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed. Results. All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR. Conclusion. MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

No MeSH data available.


Related in: MedlinePlus