Limits...
Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect

View Article: PubMed Central - PubMed

ABSTRACT

Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed. Results. All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR. Conclusion. MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

No MeSH data available.


Average total deviation for the superior and inferior hemifields (29 stimuli each). The 16 edge points (boxed points) were excluded from analyses.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5382394&req=5

fig1: Average total deviation for the superior and inferior hemifields (29 stimuli each). The 16 edge points (boxed points) were excluded from analyses.

Mentions: Standard automated perimetry was performed with an HFA (Carl Zeiss Meditec Inc., Dublin, CA, USA) using the 30-2 Swedish Interactive Threshold Algorithm. Visual field tests were considered reliable when fixation losses were <20%, false positives were <15%, and false negatives were <25%. A hemifield defect was defined as three or more significant (P < 0.05), nonedge, contiguous points, at least one highly significant (P < 0.01) point in the pattern deviation plot, and a Glaucoma Hemifield Test grading outside normal limits. A normal hemifield was defined as two or less significant (P < 0.05), nonedge contiguous points in the pattern deviation plot [37]. Average total deviations (TD) for the superior or inferior hemifields (29 stimuli each) were calculated. The 16 edge points were excluded from analyses (Figure 1). Average TD was used as retinal sensitivity, and dB was converted to the linear scale of 1/Lambert.


Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect
Average total deviation for the superior and inferior hemifields (29 stimuli each). The 16 edge points (boxed points) were excluded from analyses.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5382394&req=5

fig1: Average total deviation for the superior and inferior hemifields (29 stimuli each). The 16 edge points (boxed points) were excluded from analyses.
Mentions: Standard automated perimetry was performed with an HFA (Carl Zeiss Meditec Inc., Dublin, CA, USA) using the 30-2 Swedish Interactive Threshold Algorithm. Visual field tests were considered reliable when fixation losses were <20%, false positives were <15%, and false negatives were <25%. A hemifield defect was defined as three or more significant (P < 0.05), nonedge, contiguous points, at least one highly significant (P < 0.01) point in the pattern deviation plot, and a Glaucoma Hemifield Test grading outside normal limits. A normal hemifield was defined as two or less significant (P < 0.05), nonedge contiguous points in the pattern deviation plot [37]. Average total deviations (TD) for the superior or inferior hemifields (29 stimuli each) were calculated. The 16 edge points were excluded from analyses (Figure 1). Average TD was used as retinal sensitivity, and dB was converted to the linear scale of 1/Lambert.

View Article: PubMed Central - PubMed

ABSTRACT

Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed. Results. All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR. Conclusion. MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

No MeSH data available.