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An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

View Article: PubMed Central - PubMed

ABSTRACT

Background: The present study investigated the effect of peforelin (Maprelin®), a gonadotropin-releasing hormone (GnRH) analogue, administration in gilts, primiparous and pluriparous sows in a high productive farm on sow reproductive performance and piglet quality at birth.

Methods: In a 400 sow herd, gilts, primiparous and pluriparous sows were randomly allocated to 2 groups: peforelin treated (peforelin = P-group) or no treatment (control = C-group). Animals were injected 48 h after the last altrenogest treatment (gilts) or 24 h post weaning (sows). Weaning-to-estrus interval (WEI), estrus rate (ER), farrowing efficiency index (FEI), farrowing rate (FR), number of total (TBP), live (LBP) and stillborn piglets (SBP), mummies (MM) and live piglet index (LPI) were assessed and compared between treatment groups. To assess piglet quality at birth, 6033 piglets from 426 litters were weighed individually within 24 h after birth (BW; birth weight).

Results: No significant difference between treatment groups could be observed for WEI, TBP, LBP, SBP and MM. The ER was significantly (P = 0.0119) higher (93.2 %) in the P-group as compared to the C-group (87.2 %). Peforelin treatment did not affect farrowing rate. Both FEI and LPI were significantly (P = 0.0078) better in the P-group as compared to the C-group. Overall, no effect of peforelin treatment on piglet birth weight could be observed, although specific subcategories (1st parity and older (5+ parity) sows) did have a significant impact of treatment on birth weight. During late summer (August-September) all treated gilts and sows took advantage from peforelin treatment with a significant improvement of piglet birth weight.

Conclusion: Peforelin treatment had a significant impact on ER, FEI and LPI. Moreover, piglet birth weight improved for specific sow subcategories (1st parity and older sows) and for all gilts and sows during the late summer infertility period.

No MeSH data available.


Related in: MedlinePlus

Birth weight (average ± SEM) per treatment group (C-group, control group = yellow; P-group, peforelin-treated group = blue) blocked by parity (P0, gilts, LBP = 13.88 ± 0.35; P1, 1st parity, LBP = 13.88 ± 0.40; P2–4, 2nd to 4th parity, LBP–P2 = 14.79 ± 0.39, LBP–P3 = 14.80 ± 0.24, LBP–P4 = 15.12 ± 0.26; P5+, 5th and older parities, LBP = 13.61 ± 0.48). Significant differences (P < 0.05) between both treatment groups are indicated by an asterix (*)
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Fig3: Birth weight (average ± SEM) per treatment group (C-group, control group = yellow; P-group, peforelin-treated group = blue) blocked by parity (P0, gilts, LBP = 13.88 ± 0.35; P1, 1st parity, LBP = 13.88 ± 0.40; P2–4, 2nd to 4th parity, LBP–P2 = 14.79 ± 0.39, LBP–P3 = 14.80 ± 0.24, LBP–P4 = 15.12 ± 0.26; P5+, 5th and older parities, LBP = 13.61 ± 0.48). Significant differences (P < 0.05) between both treatment groups are indicated by an asterix (*)

Mentions: All results concerning birth weight and the effect of treatment, parity and season are shown in Figs. 1, 2 and 3. Overall, treatment with peforelin did not result in a significant increase in BW (Fig. 1). The coefficient of variation (CV) was identical (24.9 %) in both treatment groups, indicating no overall difference in homogeneity of the litters from the C-group compared to the P-group. When stratification into parities was applied, a significant impact of peforelin treatment could be observed for 1st parity sows (P < 0.05) and older sows (5th and older parities) (P < 0.05). For all other parities (gilts and 2nd–4th parity), no significant effect of peforelin treatment could be shown throughout the study. This could possibly be explained by the difference in the number of TBP among the different groups. Although these differences were non-significant, 1st parity sow and 5th and older parities had approximately 0.5 to 1 piglets less born per litter as compared to 2nd-4th parity sows, which is could partly explain the difference of around 100 g of BW in both these age groups [3]. Another explanation could be that a uniform ovulatory follicle pool at the ovary would result in a uniform oocyte quality, and an improved the luteal development [40] resulting in a better embryo quality [27, 37]. These elements could finally result in more uniform birth weights [35]. Jourquin and Goossens [17] have also shown a positive impact of peforelin treatment on the performance of the subsequent litter, which can be explained by increase of FSH, needed for follicle development [15], through peforelin treatment, resulting in larger follicles and a better pre-ovulatory follicle pool with more competent follicles to ovulate [11]. First parity sows have a higher chance of suffering from bad reproductive performance in their next cycle [29], and therefore the effect of peforelin treatment on this animal category could have a greater impact on subsequent litter quality and reproductive parameters. Older sows on the otherhand, may suffer from lower reproductive performance, since this is the major cause of culling at higher parities [7, 9]. From a practical point of view, peforelin treatment of specific subcategories of sows within a high productive sow farms could be advised throughout the year for optimization of reproductive performance.Fig. 1


An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight
Birth weight (average ± SEM) per treatment group (C-group, control group = yellow; P-group, peforelin-treated group = blue) blocked by parity (P0, gilts, LBP = 13.88 ± 0.35; P1, 1st parity, LBP = 13.88 ± 0.40; P2–4, 2nd to 4th parity, LBP–P2 = 14.79 ± 0.39, LBP–P3 = 14.80 ± 0.24, LBP–P4 = 15.12 ± 0.26; P5+, 5th and older parities, LBP = 13.61 ± 0.48). Significant differences (P < 0.05) between both treatment groups are indicated by an asterix (*)
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Related In: Results  -  Collection

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Fig3: Birth weight (average ± SEM) per treatment group (C-group, control group = yellow; P-group, peforelin-treated group = blue) blocked by parity (P0, gilts, LBP = 13.88 ± 0.35; P1, 1st parity, LBP = 13.88 ± 0.40; P2–4, 2nd to 4th parity, LBP–P2 = 14.79 ± 0.39, LBP–P3 = 14.80 ± 0.24, LBP–P4 = 15.12 ± 0.26; P5+, 5th and older parities, LBP = 13.61 ± 0.48). Significant differences (P < 0.05) between both treatment groups are indicated by an asterix (*)
Mentions: All results concerning birth weight and the effect of treatment, parity and season are shown in Figs. 1, 2 and 3. Overall, treatment with peforelin did not result in a significant increase in BW (Fig. 1). The coefficient of variation (CV) was identical (24.9 %) in both treatment groups, indicating no overall difference in homogeneity of the litters from the C-group compared to the P-group. When stratification into parities was applied, a significant impact of peforelin treatment could be observed for 1st parity sows (P < 0.05) and older sows (5th and older parities) (P < 0.05). For all other parities (gilts and 2nd–4th parity), no significant effect of peforelin treatment could be shown throughout the study. This could possibly be explained by the difference in the number of TBP among the different groups. Although these differences were non-significant, 1st parity sow and 5th and older parities had approximately 0.5 to 1 piglets less born per litter as compared to 2nd-4th parity sows, which is could partly explain the difference of around 100 g of BW in both these age groups [3]. Another explanation could be that a uniform ovulatory follicle pool at the ovary would result in a uniform oocyte quality, and an improved the luteal development [40] resulting in a better embryo quality [27, 37]. These elements could finally result in more uniform birth weights [35]. Jourquin and Goossens [17] have also shown a positive impact of peforelin treatment on the performance of the subsequent litter, which can be explained by increase of FSH, needed for follicle development [15], through peforelin treatment, resulting in larger follicles and a better pre-ovulatory follicle pool with more competent follicles to ovulate [11]. First parity sows have a higher chance of suffering from bad reproductive performance in their next cycle [29], and therefore the effect of peforelin treatment on this animal category could have a greater impact on subsequent litter quality and reproductive parameters. Older sows on the otherhand, may suffer from lower reproductive performance, since this is the major cause of culling at higher parities [7, 9]. From a practical point of view, peforelin treatment of specific subcategories of sows within a high productive sow farms could be advised throughout the year for optimization of reproductive performance.Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: The present study investigated the effect of peforelin (Maprelin&reg;), a gonadotropin-releasing hormone (GnRH) analogue, administration in gilts, primiparous and pluriparous sows in a high productive farm on sow reproductive performance and piglet quality at birth.

Methods: In a 400 sow herd, gilts, primiparous and pluriparous sows were randomly allocated to 2 groups: peforelin treated (peforelin&thinsp;=&thinsp;P-group) or no treatment (control&thinsp;=&thinsp;C-group). Animals were injected 48&nbsp;h after the last altrenogest treatment (gilts) or 24&nbsp;h post weaning (sows). Weaning-to-estrus interval (WEI), estrus rate (ER), farrowing efficiency index (FEI), farrowing rate (FR), number of total (TBP), live (LBP) and stillborn piglets (SBP), mummies (MM) and live piglet index (LPI) were assessed and compared between treatment groups. To assess piglet quality at birth, 6033 piglets from 426 litters were weighed individually within 24&nbsp;h after birth (BW; birth weight).

Results: No significant difference between treatment groups could be observed for WEI, TBP, LBP, SBP and MM. The ER was significantly (P&thinsp;=&thinsp;0.0119) higher (93.2&nbsp;%) in the P-group as compared to the C-group (87.2&nbsp;%). Peforelin treatment did not affect farrowing rate. Both FEI and LPI were significantly (P&thinsp;=&thinsp;0.0078) better in the P-group as compared to the C-group. Overall, no effect of peforelin treatment on piglet birth weight could be observed, although specific subcategories (1st parity and older (5+ parity) sows) did have a significant impact of treatment on birth weight. During late summer (August-September) all treated gilts and sows took advantage from peforelin treatment with a significant improvement of piglet birth weight.

Conclusion: Peforelin treatment had a significant impact on ER, FEI and LPI. Moreover, piglet birth weight improved for specific sow subcategories (1st parity and older sows) and for all gilts and sows during the late summer infertility period.

No MeSH data available.


Related in: MedlinePlus