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Recent progress on magnetic nanoparticlesfor magnetic hyperthermia

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ABSTRACT

Recent advances in nanomaterials science contributed to develop newmicro- and nano-devices as potential diagnostic and therapeutic tools in the fieldof oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has beenintensively studied, and the use of these particles in magnetic hyperthermia therapyhas demonstrated successes in treatment of cancer. However, some physicallimitations have been found to impact the heating efficiency required to kill cancercells. Moreover, the bio-safety of NPs remains largely unexplored. The primary goalsof this review are to summarize the recent progress in the development of magneticnanoparticles (MNPs) for hyperthermia, and discuss the limitations and advances inthe synthesis of these particles. Based on this knowledge, new perspectives ondevelopment of new biocompatible and biofunctional nanomaterials for magnetichyperthermia are discussed.

No MeSH data available.


Pourbaix diagram showing iron and palladium species and waterstability region (reproduced from Villicaña et al. 2007)
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Fig6: Pourbaix diagram showing iron and palladium species and waterstability region (reproduced from Villicaña et al. 2007)

Mentions: Potential (Eh)-pH diagram or Pourbaix diagram is essential toinvestigate the thermodynamic of material corrosion, by monitoring the regions ofpotential and pH where the metal is: unreacted (region of immunity), protected by asurface film of an oxide or a hydroxide (region of passivity) or dissolved (regionof corrosion) (McCafferty 2010).Figure 6 shows the Pourbaix diagram forboth iron and palladium elements in water containing fluoride ions (Villicaña et al.2007). According to the diagram, ironwill corrode and produce Fe(II) and/or Fe(III) at potential zero and at pH below 6,whereas palladium remains unreacted under these conditions. This difference instability is due to the higher reactivity of iron towards oxidation ( = −0.44 V;  = −0.04 V), compared with palladium ( = +0.915 V). Moreover, iron forms a porous oxide layer whenexposed to water or air (Hill and Holman 2000), and consequently anodic (iron)/cathodic (iron oxide) sitescreated at the surface trigger the process of corrosion.Fig. 6


Recent progress on magnetic nanoparticlesfor magnetic hyperthermia
Pourbaix diagram showing iron and palladium species and waterstability region (reproduced from Villicaña et al. 2007)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5304434&req=5

Fig6: Pourbaix diagram showing iron and palladium species and waterstability region (reproduced from Villicaña et al. 2007)
Mentions: Potential (Eh)-pH diagram or Pourbaix diagram is essential toinvestigate the thermodynamic of material corrosion, by monitoring the regions ofpotential and pH where the metal is: unreacted (region of immunity), protected by asurface film of an oxide or a hydroxide (region of passivity) or dissolved (regionof corrosion) (McCafferty 2010).Figure 6 shows the Pourbaix diagram forboth iron and palladium elements in water containing fluoride ions (Villicaña et al.2007). According to the diagram, ironwill corrode and produce Fe(II) and/or Fe(III) at potential zero and at pH below 6,whereas palladium remains unreacted under these conditions. This difference instability is due to the higher reactivity of iron towards oxidation ( = −0.44 V;  = −0.04 V), compared with palladium ( = +0.915 V). Moreover, iron forms a porous oxide layer whenexposed to water or air (Hill and Holman 2000), and consequently anodic (iron)/cathodic (iron oxide) sitescreated at the surface trigger the process of corrosion.Fig. 6

View Article: PubMed Central - PubMed

ABSTRACT

Recent advances in nanomaterials science contributed to develop newmicro- and nano-devices as potential diagnostic and therapeutic tools in the fieldof oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has beenintensively studied, and the use of these particles in magnetic hyperthermia therapyhas demonstrated successes in treatment of cancer. However, some physicallimitations have been found to impact the heating efficiency required to kill cancercells. Moreover, the bio-safety of NPs remains largely unexplored. The primary goalsof this review are to summarize the recent progress in the development of magneticnanoparticles (MNPs) for hyperthermia, and discuss the limitations and advances inthe synthesis of these particles. Based on this knowledge, new perspectives ondevelopment of new biocompatible and biofunctional nanomaterials for magnetichyperthermia are discussed.

No MeSH data available.