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Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi

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ABSTRACT

Reelin is an extracellular signaling protein synthesized by Cajal-Retius cells in utero and early after birth, its presence being signaled in adult life too. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons.

We investigated the reelin presence and its receptors, VLDLR and ApoER2, in melanocytic nevi considering the neural crest origin of the nevus cells and their migration into skin during embrionary period.

Melanocytic nevi present a strict cellular architecture and an increased malignant transforming capacity. We investigated reelin presence in 32 melanocytic nevi (5 junctional, 27 compound or 14 dysplastic nevi and 18 non dysplastic nevi). The assessment of reelin presence was performed by histological semiquantitative criteria.

Results showed the presence of reelin in 29 cases (29/ 32). The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. Reelin or its receptors was peritumorally absent. Our study showed the presence of reelin in nevus cells from cutaneous melanocytic nevi and, in these cells, only the VLDLR receptor was present in half of the cases.

The significance of the reelin presence in cutaneous nevus cells may be hypothetically considered correlated with the position maintenance of the nevus cells or migration of these cells in malignant transforming situation.

Abbreviations:: ApoER2 = apolipoprotein receptor 2, VLDLR = very low density lipoprotein receptor, DAB-1 = DIABLO protein, HMB45 = gene HMB45

No MeSH data available.


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c. Junctional nevus with intense positive reelin at IHC junctional area with anti reelin antibodies (100X)
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Figure 3: c. Junctional nevus with intense positive reelin at IHC junctional area with anti reelin antibodies (100X)

Mentions: Reelin expression was absent in 9% of the cases (3/ 32). All the junctional nevi (6/ 32) and 23 of the compound nevi expressed reelin in the junctional area (9/ 32), in the superficial dermis in 15 cases (15/ 23) and in the deep dermis in 8 cases (8/ 23), respectively. In 4 cases, reelin was present both in the junctional area and the superficial area in the same compound nevus. The dysplastic compound and junctional nevi showed positive values for reelin in all cases: 37% (5/ 14) intensely positive, 57% (8/ 14) average, and 6% (1/ 14) weakly positive, respectively. Non-dysplastic nevi stained intensely positive for reelin in 16% of the cases (3/ 18), moderately positive in 16% of the cases (3/ 18), and weakly positive or negative in 50% of the cases (9/ 18 and 3/ 18, respectively) (Fig. 1 a,b,c).


Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi
c. Junctional nevus with intense positive reelin at IHC junctional area with anti reelin antibodies (100X)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5304381&req=5

Figure 3: c. Junctional nevus with intense positive reelin at IHC junctional area with anti reelin antibodies (100X)
Mentions: Reelin expression was absent in 9% of the cases (3/ 32). All the junctional nevi (6/ 32) and 23 of the compound nevi expressed reelin in the junctional area (9/ 32), in the superficial dermis in 15 cases (15/ 23) and in the deep dermis in 8 cases (8/ 23), respectively. In 4 cases, reelin was present both in the junctional area and the superficial area in the same compound nevus. The dysplastic compound and junctional nevi showed positive values for reelin in all cases: 37% (5/ 14) intensely positive, 57% (8/ 14) average, and 6% (1/ 14) weakly positive, respectively. Non-dysplastic nevi stained intensely positive for reelin in 16% of the cases (3/ 18), moderately positive in 16% of the cases (3/ 18), and weakly positive or negative in 50% of the cases (9/ 18 and 3/ 18, respectively) (Fig. 1 a,b,c).

View Article: PubMed Central - PubMed

ABSTRACT

Reelin is an extracellular signaling protein synthesized by Cajal-Retius cells in utero and early after birth, its presence being signaled in adult life too. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons.

We investigated the reelin presence and its receptors, VLDLR and ApoER2, in melanocytic nevi considering the neural crest origin of the nevus cells and their migration into skin during embrionary period.

Melanocytic nevi present a strict cellular architecture and an increased malignant transforming capacity. We investigated reelin presence in 32 melanocytic nevi (5 junctional, 27 compound or 14 dysplastic nevi and 18 non dysplastic nevi). The assessment of reelin presence was performed by histological semiquantitative criteria.

Results showed the presence of reelin in 29 cases (29/ 32). The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. Reelin or its receptors was peritumorally absent. Our study showed the presence of reelin in nevus cells from cutaneous melanocytic nevi and, in these cells, only the VLDLR receptor was present in half of the cases.

The significance of the reelin presence in cutaneous nevus cells may be hypothetically considered correlated with the position maintenance of the nevus cells or migration of these cells in malignant transforming situation.

Abbreviations:: ApoER2 = apolipoprotein receptor 2, VLDLR = very low density lipoprotein receptor, DAB-1 = DIABLO protein, HMB45 = gene HMB45

No MeSH data available.


Related in: MedlinePlus