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Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma

View Article: PubMed Central - PubMed

ABSTRACT

Cigarette smoke plays a substantial role in the development of airway inflammatory diseases, including asthma and chronic rhinosinusitis (CRS). Interleukin (IL)-17A might contribute to cigarette smoke-related inflammation of the airway. This study aimed to investigate the association between cigarette smoking and IL-17A expression in the nasal tissues of patients with CRS and asthma.

We prospectively recruited 24 patients (13 smokers, 11 nonsmokers) with CRS and asthma and 6 patients with asthma but without CRS (control group) in a tertiary medical center. Nasal mucosa was obtained as part of the nasal surgery. Protein and mRNA levels of IL-17A in the nasal tissues were determined by immunostaining and real-time polymerase chain reaction.

The number of unexpected emergency clinic visits for acute asthma attacks were higher among smokers than among nonsmokers. Interleukin-17A protein and mRNA levels in the nasal tissues of smokers were greater compared to those in the nasal tissues of nonsmokers (P = 0.02 both) and control patients (P = 0.05 and 0.04, respectively).

Cigarette smoking was associated with an increase in the number of unexpected emergency clinic visits due to acute asthma attack and in the expression of IL-17A in the nasal tissues of patients with airway inflammatory diseases.

No MeSH data available.


Related in: MedlinePlus

Correlation between interleukin-17A mRNA expressions levels and various airway parameters. The mRNA expression levels of IL-17A were not correlated with the sino-nasal outcome test (SNOT)-22 (A), computed tomography (CT) (B), or asthma control test (ACT) (C) scores. However, they were well correlated with the predicted ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity (FVC) (D). The data were analyzed by Spearman's correlation coefficient analysis. ∗Significance was considered at P < 0.05. ACT = asthma control test, CT = computed tomography, FEV1 = forced expiratory volume in 1s, FVC = forced vital capacity, SNOT-22 = sino-nasal outcome test-22.
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Figure 3: Correlation between interleukin-17A mRNA expressions levels and various airway parameters. The mRNA expression levels of IL-17A were not correlated with the sino-nasal outcome test (SNOT)-22 (A), computed tomography (CT) (B), or asthma control test (ACT) (C) scores. However, they were well correlated with the predicted ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity (FVC) (D). The data were analyzed by Spearman's correlation coefficient analysis. ∗Significance was considered at P < 0.05. ACT = asthma control test, CT = computed tomography, FEV1 = forced expiratory volume in 1s, FVC = forced vital capacity, SNOT-22 = sino-nasal outcome test-22.

Mentions: The mRNA expression levels of IL-17A were not correlated with the sinus subjective SNOT-22 scores (Fig. 3A), objective CT scores for evaluation of CRS (Fig. 3B),or subjective ACT scores for asthma control (Fig. 3C); however, they were well correlated with the predicted FEV1/FVC ratio in the pulmonary function test (Fig. 3D).


Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma
Correlation between interleukin-17A mRNA expressions levels and various airway parameters. The mRNA expression levels of IL-17A were not correlated with the sino-nasal outcome test (SNOT)-22 (A), computed tomography (CT) (B), or asthma control test (ACT) (C) scores. However, they were well correlated with the predicted ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity (FVC) (D). The data were analyzed by Spearman's correlation coefficient analysis. ∗Significance was considered at P < 0.05. ACT = asthma control test, CT = computed tomography, FEV1 = forced expiratory volume in 1s, FVC = forced vital capacity, SNOT-22 = sino-nasal outcome test-22.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134879&req=5

Figure 3: Correlation between interleukin-17A mRNA expressions levels and various airway parameters. The mRNA expression levels of IL-17A were not correlated with the sino-nasal outcome test (SNOT)-22 (A), computed tomography (CT) (B), or asthma control test (ACT) (C) scores. However, they were well correlated with the predicted ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity (FVC) (D). The data were analyzed by Spearman's correlation coefficient analysis. ∗Significance was considered at P < 0.05. ACT = asthma control test, CT = computed tomography, FEV1 = forced expiratory volume in 1s, FVC = forced vital capacity, SNOT-22 = sino-nasal outcome test-22.
Mentions: The mRNA expression levels of IL-17A were not correlated with the sinus subjective SNOT-22 scores (Fig. 3A), objective CT scores for evaluation of CRS (Fig. 3B),or subjective ACT scores for asthma control (Fig. 3C); however, they were well correlated with the predicted FEV1/FVC ratio in the pulmonary function test (Fig. 3D).

View Article: PubMed Central - PubMed

ABSTRACT

Cigarette smoke plays a substantial role in the development of airway inflammatory diseases, including asthma and chronic rhinosinusitis (CRS). Interleukin (IL)-17A might contribute to cigarette smoke-related inflammation of the airway. This study aimed to investigate the association between cigarette smoking and IL-17A expression in the nasal tissues of patients with CRS and asthma.

We prospectively recruited 24 patients (13 smokers, 11 nonsmokers) with CRS and asthma and 6 patients with asthma but without CRS (control group) in a tertiary medical center. Nasal mucosa was obtained as part of the nasal surgery. Protein and mRNA levels of IL-17A in the nasal tissues were determined by immunostaining and real-time polymerase chain reaction.

The number of unexpected emergency clinic visits for acute asthma attacks were higher among smokers than among nonsmokers. Interleukin-17A protein and mRNA levels in the nasal tissues of smokers were greater compared to those in the nasal tissues of nonsmokers (P&#8202;=&#8202;0.02 both) and control patients (P&#8202;=&#8202;0.05 and 0.04, respectively).

Cigarette smoking was associated with an increase in the number of unexpected emergency clinic visits due to acute asthma attack and in the expression of IL-17A in the nasal tissues of patients with airway inflammatory diseases.

No MeSH data available.


Related in: MedlinePlus