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Serum CA125 concentration as a predictor of peritoneal dissemination of colorectal cancer in men and women

View Article: PubMed Central - PubMed

ABSTRACT

Peritoneal dissemination (PD) of cancer is difficult to diagnose. Previous reports have shown that carbohydrate antigen 125 (CA125) is a sensitive marker of PD of gastric cancer. However, CA125 has not been evaluated as a marker of colorectal cancer (CRC), and its accuracy in men is controversial. The aim of this study was to compare the ability of CA125 and carcinoembryonic antigen (CEA) to predict PD of CRC in men and women.

Preoperative CA125 and CEA concentrations were measured in 853 people (510 men, 343 women) over 10 years. PD was confirmed intraoperatively in 57 patients. The predictive ability was compared between CA125 and CEA.

Compared with CEA, CA125 concentration had a lower sensitivity, higher specificity, and diagnostic accuracy, and significantly greater area under the curve. Further analysis of CA125's sensitivity and specificity among CEA-negative group (n = 514) showed acceptable sensitivity (57.1%) and good specificity (92.0%). In men and women, CA125 concentration did not increase with stage from I to IV unless PD was present (P < 0.001). CEA concentration was increased in women with metastasis with PD (P < 0.001) or without PD (P < 0.001), but was increased only in men with metastasis without PD (P < 0.01). CA125 concentration correlated with PD grade for men and women, but CEA concentration correlated with grade only in women.

When analyzed according to the primary tumor site, CA125 concentration in men did not differ between patients with the primary site in the right or left colon, or the rectum, regardless of PD status. By contrast, CA125 concentration differed between PD-positive and PD-negative patients with cancer in the right (P < 0.001) or left (P < 0.001) colon but not in the rectum. CEA concentration in men did not differ according to the primary site or PD status. In women, CA125 and CEA concentrations differed significantly between the PD-positive and PD-negative groups in patients with the primary tumor in the right (P < 0.001) or left (P < 0.001) colon; tumor sites did not differ between the PD-positive and PD-negative groups.

These findings suggest that CA125 is a better tumor marker than CEA for predicting PD of CRC in both men and women.

No MeSH data available.


Related in: MedlinePlus

CA125 and CEA concentrations grouped according to tumor stage in men (A) and women (B). The asterisk indicates a significant difference compared with the nonmetastases group. CA125 = carbohydrate antigen 125, CEA = carcinoembryonic antigen, PD = peritoneal dissemination.
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Figure 1: CA125 and CEA concentrations grouped according to tumor stage in men (A) and women (B). The asterisk indicates a significant difference compared with the nonmetastases group. CA125 = carbohydrate antigen 125, CEA = carcinoembryonic antigen, PD = peritoneal dissemination.

Mentions: The distributions of CA125 and CEA concentrations according to tumor stages for both men and women are shown in Fig. 1. In men (Fig. 1A), CA125 concentration did not increase significantly from Stage I to IV (without PD) unless PD was present (P < 0.001) CEA concentration was increased significantly only in patients with Stage IV without PD (P < 0.01). CEA concentration was not significantly higher in patients with PD compared with patients without metastases. In women (Fig. 1B), CA125 concentration was significantly increased in those with PD (P < 0.001), as observed for men. In patients with Stage IV disease, both patients with PD (P < 0.001) and without PD (P < 0.001) had a significantly higher CEA concentration compared with patients without metastases. CEA concentration did not differ between patients with and without PD.


Serum CA125 concentration as a predictor of peritoneal dissemination of colorectal cancer in men and women
CA125 and CEA concentrations grouped according to tumor stage in men (A) and women (B). The asterisk indicates a significant difference compared with the nonmetastases group. CA125 = carbohydrate antigen 125, CEA = carcinoembryonic antigen, PD = peritoneal dissemination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134852&req=5

Figure 1: CA125 and CEA concentrations grouped according to tumor stage in men (A) and women (B). The asterisk indicates a significant difference compared with the nonmetastases group. CA125 = carbohydrate antigen 125, CEA = carcinoembryonic antigen, PD = peritoneal dissemination.
Mentions: The distributions of CA125 and CEA concentrations according to tumor stages for both men and women are shown in Fig. 1. In men (Fig. 1A), CA125 concentration did not increase significantly from Stage I to IV (without PD) unless PD was present (P < 0.001) CEA concentration was increased significantly only in patients with Stage IV without PD (P < 0.01). CEA concentration was not significantly higher in patients with PD compared with patients without metastases. In women (Fig. 1B), CA125 concentration was significantly increased in those with PD (P < 0.001), as observed for men. In patients with Stage IV disease, both patients with PD (P < 0.001) and without PD (P < 0.001) had a significantly higher CEA concentration compared with patients without metastases. CEA concentration did not differ between patients with and without PD.

View Article: PubMed Central - PubMed

ABSTRACT

Peritoneal dissemination (PD) of cancer is difficult to diagnose. Previous reports have shown that carbohydrate antigen 125 (CA125) is a sensitive marker of PD of gastric cancer. However, CA125 has not been evaluated as a marker of colorectal cancer (CRC), and its accuracy in men is controversial. The aim of this study was to compare the ability of CA125 and carcinoembryonic antigen (CEA) to predict PD of CRC in men and women.

Preoperative CA125 and CEA concentrations were measured in 853 people (510 men, 343 women) over 10 years. PD was confirmed intraoperatively in 57 patients. The predictive ability was compared between CA125 and CEA.

Compared with CEA, CA125 concentration had a lower sensitivity, higher specificity, and diagnostic accuracy, and significantly greater area under the curve. Further analysis of CA125's sensitivity and specificity among CEA-negative group (n&#8202;=&#8202;514) showed acceptable sensitivity (57.1%) and good specificity (92.0%). In men and women, CA125 concentration did not increase with stage from I to IV unless PD was present (P&#8202;&lt;&#8202;0.001). CEA concentration was increased in women with metastasis with PD (P&#8202;&lt;&#8202;0.001) or without PD (P&#8202;&lt;&#8202;0.001), but was increased only in men with metastasis without PD (P&#8202;&lt;&#8202;0.01). CA125 concentration correlated with PD grade for men and women, but CEA concentration correlated with grade only in women.

When analyzed according to the primary tumor site, CA125 concentration in men did not differ between patients with the primary site in the right or left colon, or the rectum, regardless of PD status. By contrast, CA125 concentration differed between PD-positive and PD-negative patients with cancer in the right (P&#8202;&lt;&#8202;0.001) or left (P&#8202;&lt;&#8202;0.001) colon but not in the rectum. CEA concentration in men did not differ according to the primary site or PD status. In women, CA125 and CEA concentrations differed significantly between the PD-positive and PD-negative groups in patients with the primary tumor in the right (P&#8202;&lt;&#8202;0.001) or left (P&#8202;&lt;&#8202;0.001) colon; tumor sites did not differ between the PD-positive and PD-negative groups.

These findings suggest that CA125 is a better tumor marker than CEA for predicting PD of CRC in both men and women.

No MeSH data available.


Related in: MedlinePlus