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Adjuvant radiotherapy for the treatment of stage IV rectal cancer after curative resection

View Article: PubMed Central - PubMed

ABSTRACT

The role of pelvic radiotherapy (RT) in stage IV rectal cancer with total mesorectal excision (TME) has not been defined. We evaluated the impact of RT on oncologic outcomes among patients with stage IV rectal cancer who underwent TME and performed a meta-analysis of published studies.

The records of stage IV rectal cancer patients who underwent TME between August 2001 and December 2011 were reviewed. Patients who received pelvic RT (RT group) and those who did not (non-RT group) were matched using a propensity score. Oncologic outcomes were compared between the groups. A systematic literature search and meta-analysis was conducted.

One hundred seventy-six patients were matched with propensity score matching, resulting in 39 patients in each group. The local recurrence-free survival (LRFS) of the RT group was significantly higher than that of the non-RT group (2-year LRFS: 100% vs 83.6%, respectively, P = 0.038). The overall survival, disease-free survival, and systemic recurrence were not significantly different between the groups. In the meta-analysis, the RT group had a reduced risk for loco-regional recurrence than the non-RT group (RR: 0.48, 95% confidence interval: 0.29–0.79).

Pelvic RT might have benefits for loco-regional control in patients with stage IV rectal cancer who undergo TME.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the effect of postoperative radiotherapy on local recurrence in stage IV rectal cancer. CI = confidence interval, DF = degrees of freedom, RT = radiotherapy.
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Figure 2: Meta-analysis of the effect of postoperative radiotherapy on local recurrence in stage IV rectal cancer. CI = confidence interval, DF = degrees of freedom, RT = radiotherapy.

Mentions: With the addition of the results from our study, the pooled risks for loco-regional and systemic recurrence were estimated and compared between the 2 groups. Overall, 455 patients (168 in the RT group and 287 in the non-RT group) were analyzed. The RT group had a significantly reduced risk for loco-regional recurrence compared with the non-RT group (RR; 0.48, 95% CI; 0.29–0.79, P = 0.004) (Fig. 2). There was no significant difference in the risk of systemic recurrence between the 2 groups (RR; 1.10, 95% CI; 0.96–1.25, P = 0.17) (Fig. 3). Relatively symmetric-shaped funnel plots were generated in both analyses (Fig. 4), indicating a low possibility of publication bias.


Adjuvant radiotherapy for the treatment of stage IV rectal cancer after curative resection
Meta-analysis of the effect of postoperative radiotherapy on local recurrence in stage IV rectal cancer. CI = confidence interval, DF = degrees of freedom, RT = radiotherapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134846&req=5

Figure 2: Meta-analysis of the effect of postoperative radiotherapy on local recurrence in stage IV rectal cancer. CI = confidence interval, DF = degrees of freedom, RT = radiotherapy.
Mentions: With the addition of the results from our study, the pooled risks for loco-regional and systemic recurrence were estimated and compared between the 2 groups. Overall, 455 patients (168 in the RT group and 287 in the non-RT group) were analyzed. The RT group had a significantly reduced risk for loco-regional recurrence compared with the non-RT group (RR; 0.48, 95% CI; 0.29–0.79, P = 0.004) (Fig. 2). There was no significant difference in the risk of systemic recurrence between the 2 groups (RR; 1.10, 95% CI; 0.96–1.25, P = 0.17) (Fig. 3). Relatively symmetric-shaped funnel plots were generated in both analyses (Fig. 4), indicating a low possibility of publication bias.

View Article: PubMed Central - PubMed

ABSTRACT

The role of pelvic radiotherapy (RT) in stage IV rectal cancer with total mesorectal excision (TME) has not been defined. We evaluated the impact of RT on oncologic outcomes among patients with stage IV rectal cancer who underwent TME and performed a meta-analysis of published studies.

The records of stage IV rectal cancer patients who underwent TME between August 2001 and December 2011 were reviewed. Patients who received pelvic RT (RT group) and those who did not (non-RT group) were matched using a propensity score. Oncologic outcomes were compared between the groups. A systematic literature search and meta-analysis was conducted.

One hundred seventy-six patients were matched with propensity score matching, resulting in 39 patients in each group. The local recurrence-free survival (LRFS) of the RT group was significantly higher than that of the non-RT group (2-year LRFS: 100% vs 83.6%, respectively, P = 0.038). The overall survival, disease-free survival, and systemic recurrence were not significantly different between the groups. In the meta-analysis, the RT group had a reduced risk for loco-regional recurrence than the non-RT group (RR: 0.48, 95% confidence interval: 0.29–0.79).

Pelvic RT might have benefits for loco-regional control in patients with stage IV rectal cancer who undergo TME.

No MeSH data available.


Related in: MedlinePlus