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Correlation between T2 ∗ (T2 star) relaxation time and cervical intervertebral disc degeneration

View Article: PubMed Central - PubMed

ABSTRACT

Purpose:: To demonstrate the potential benefits of T2∗ relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting.

Materials and methods:: Cervical sagittal T2-weighted, T2∗ relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2–3 to C6–7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2∗ mapping. Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.

Results:: Cervical intervertebral discs (IVDs) of patients were commonly determined to be at Pfirrmann grades III to V. The nucleus pulposus (NP) values did not differ significantly between sexes at the same anatomic level (P > 0.05). In the NP, the T2∗ values tended to decrease with increasing grade (P < 0.000), and a significant difference was found in the T2 values between grades I to V (P < 0.05). T2∗ values based on disc degeneration level classification were as follows: grade I (>30 milliseconds), grade II (24.55–29.99 milliseconds), grade III (21.65–24.54 milliseconds), grade IV (18.35–21.64 milliseconds), and grade V (<18.34 milliseconds).

Conclusion:: Our standardized method of region-specific quantitative T2∗ relaxation time evaluation seems capable of characterizing different degrees of disc degeneration quantitatively. The T2∗ values obtained in these cervical IVDs may serve as baseline values for future T2∗ measurements in both healthy and degenerated cervical discs.

No MeSH data available.


For the representative intervertebral disc, regions of interests (ROIs) evaluation on the sagittal T2WI (A), an ellipse ROI was selected for the nucleus pulposus (NP). Then these ROIs inT2WI were copied to the T2∗ colored map (B). T2∗ values were measured.
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Figure 1: For the representative intervertebral disc, regions of interests (ROIs) evaluation on the sagittal T2WI (A), an ellipse ROI was selected for the nucleus pulposus (NP). Then these ROIs inT2WI were copied to the T2∗ colored map (B). T2∗ values were measured.

Mentions: Morphological evaluation of images was carried out by 2 radiologists in consensus (MH, 10 years of experience with a special interest in musculoskeletal radiology, and LC, more than 20 years of experience in orthopedic radiology). Five IVDs (C2–C7) of the cervical spine were assessed on the sagittal T2-weighted fast spin echo (FSE) images. We decided to adopt the method reported by previous studies.[15–17] To minimize the error in identifying nucleus pulposus (NP) anatomic structure, free hand regions of interests (ROIs) for Pfirrmann grades I to V manually drawn on the inner portion of each cervical disc were carefully matched to the NP shape on the T2WI images and copied to the corresponding T2∗ maps (Fig. 1). T2∗ values were reported as mean ± SD.


Correlation between T2 ∗ (T2 star) relaxation time and cervical intervertebral disc degeneration
For the representative intervertebral disc, regions of interests (ROIs) evaluation on the sagittal T2WI (A), an ellipse ROI was selected for the nucleus pulposus (NP). Then these ROIs inT2WI were copied to the T2∗ colored map (B). T2∗ values were measured.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134845&req=5

Figure 1: For the representative intervertebral disc, regions of interests (ROIs) evaluation on the sagittal T2WI (A), an ellipse ROI was selected for the nucleus pulposus (NP). Then these ROIs inT2WI were copied to the T2∗ colored map (B). T2∗ values were measured.
Mentions: Morphological evaluation of images was carried out by 2 radiologists in consensus (MH, 10 years of experience with a special interest in musculoskeletal radiology, and LC, more than 20 years of experience in orthopedic radiology). Five IVDs (C2–C7) of the cervical spine were assessed on the sagittal T2-weighted fast spin echo (FSE) images. We decided to adopt the method reported by previous studies.[15–17] To minimize the error in identifying nucleus pulposus (NP) anatomic structure, free hand regions of interests (ROIs) for Pfirrmann grades I to V manually drawn on the inner portion of each cervical disc were carefully matched to the NP shape on the T2WI images and copied to the corresponding T2∗ maps (Fig. 1). T2∗ values were reported as mean ± SD.

View Article: PubMed Central - PubMed

ABSTRACT

Purpose:: To demonstrate the potential benefits of T2∗ relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting.

Materials and methods:: Cervical sagittal T2-weighted, T2∗ relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2–3 to C6–7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2∗ mapping. Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.

Results:: Cervical intervertebral discs (IVDs) of patients were commonly determined to be at Pfirrmann grades III to V. The nucleus pulposus (NP) values did not differ significantly between sexes at the same anatomic level (P > 0.05). In the NP, the T2∗ values tended to decrease with increasing grade (P < 0.000), and a significant difference was found in the T2 values between grades I to V (P < 0.05). T2∗ values based on disc degeneration level classification were as follows: grade I (>30 milliseconds), grade II (24.55–29.99 milliseconds), grade III (21.65–24.54 milliseconds), grade IV (18.35–21.64 milliseconds), and grade V (<18.34 milliseconds).

Conclusion:: Our standardized method of region-specific quantitative T2∗ relaxation time evaluation seems capable of characterizing different degrees of disc degeneration quantitatively. The T2∗ values obtained in these cervical IVDs may serve as baseline values for future T2∗ measurements in both healthy and degenerated cervical discs.

No MeSH data available.