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Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy

View Article: PubMed Central - PubMed

ABSTRACT

Background:: The diagnosis of tuberculous pleurisy is difficult and traditional methods are not always helpful. Many studies have focused on the tumor necrosis factor-alpha (TNF-α) assay in pleural effusion for the diagnosis of tuberculous pleurisy, but the results remain controversial. This meta-analysis was conducted to determine the overall diagnostic accuracy of TNF-α.

Methods:: Relevant studies were searched from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wangfang, and Weipu. We pooled the published results and computed the accuracy measures, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Receiver operating characteristic curves (SROC) and the area under the curve (AUC) were used to summarize the overall test performance.

Results:: Twelve studies with 1022 patients met the inclusion criteria. The pooled sensitivity and specificity were 0.85 (95%CI, 0.81–0.89) and 0.80 (95% CI, 0.77–0.83) respectively. The area under the SROC curve was 0.89.

Conclusions:: The results of meta-analysis suggested that the TNF-α assay plays a vital role in the diagnosis of tuberculous pleurisy, whereas other test results or clinical findings should be interpreted together with the TNF-α assay to improve the overall diagnostic accuracy.

No MeSH data available.


Related in: MedlinePlus

Summary receiver operating characteristic curve (SROC) of TNF-α assay for the diagnosis of TPE. The size of each solid circle represents the sample size of each study. The regression SROC curve indicates the overall diagnostic accuracy. SROC = Summary receiver operating characteristic curve, TPE = tuberculous pleural effusion.
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Figure 4: Summary receiver operating characteristic curve (SROC) of TNF-α assay for the diagnosis of TPE. The size of each solid circle represents the sample size of each study. The regression SROC curve indicates the overall diagnostic accuracy. SROC = Summary receiver operating characteristic curve, TPE = tuberculous pleural effusion.

Mentions: To summarize the global diagnostic performance of the test, the summary receiver operating characteristic (SROC) curve was generated and the Q-value, the point represents the maximum polymerization spot of sensitivity and specificity in the SROC curve, was also calculated.[38] As is shown in Fig. 4, in our study, the area under the curve (AUC) was 0.89 and the Q-value was 0.82, suggesting a relatively high diagnostic accuracy.


Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy
Summary receiver operating characteristic curve (SROC) of TNF-α assay for the diagnosis of TPE. The size of each solid circle represents the sample size of each study. The regression SROC curve indicates the overall diagnostic accuracy. SROC = Summary receiver operating characteristic curve, TPE = tuberculous pleural effusion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134804&req=5

Figure 4: Summary receiver operating characteristic curve (SROC) of TNF-α assay for the diagnosis of TPE. The size of each solid circle represents the sample size of each study. The regression SROC curve indicates the overall diagnostic accuracy. SROC = Summary receiver operating characteristic curve, TPE = tuberculous pleural effusion.
Mentions: To summarize the global diagnostic performance of the test, the summary receiver operating characteristic (SROC) curve was generated and the Q-value, the point represents the maximum polymerization spot of sensitivity and specificity in the SROC curve, was also calculated.[38] As is shown in Fig. 4, in our study, the area under the curve (AUC) was 0.89 and the Q-value was 0.82, suggesting a relatively high diagnostic accuracy.

View Article: PubMed Central - PubMed

ABSTRACT

Background:: The diagnosis of tuberculous pleurisy is difficult and traditional methods are not always helpful. Many studies have focused on the tumor necrosis factor-alpha (TNF-α) assay in pleural effusion for the diagnosis of tuberculous pleurisy, but the results remain controversial. This meta-analysis was conducted to determine the overall diagnostic accuracy of TNF-α.

Methods:: Relevant studies were searched from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wangfang, and Weipu. We pooled the published results and computed the accuracy measures, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Receiver operating characteristic curves (SROC) and the area under the curve (AUC) were used to summarize the overall test performance.

Results:: Twelve studies with 1022 patients met the inclusion criteria. The pooled sensitivity and specificity were 0.85 (95%CI, 0.81–0.89) and 0.80 (95% CI, 0.77–0.83) respectively. The area under the SROC curve was 0.89.

Conclusions:: The results of meta-analysis suggested that the TNF-α assay plays a vital role in the diagnosis of tuberculous pleurisy, whereas other test results or clinical findings should be interpreted together with the TNF-α assay to improve the overall diagnostic accuracy.

No MeSH data available.


Related in: MedlinePlus