Limits...
Similar environments but diverse fates: Responses of budding yeast tonutrient deprivation

View Article: PubMed Central - PubMed

ABSTRACT

Diploid budding yeast (Saccharomyces cerevisiae) can adopt oneof several alternative differentiation fates in response to nutrient limitation,and each of these fates provides distinct biological functions. When differentstrain backgrounds are taken into account, these various fates occur in responseto similar environmental cues, are regulated by the same signal transductionpathways, and share many of the same master regulators. I propose that therelationships between fate choice, environmental cues and signaling pathways arenot Boolean, but involve graded levels of signals, pathway activation andmaster-regulator activity. In the absence of large differences betweenenvironmental cues, small differences in the concentration of cues may bereinforced by cell-to-cell signals. These signals are particularly essential forfate determination within communities, such as colonies and biofilms, where fatechoice varies dramatically from one region of the community to another. The lackof Boolean relationships between cues, signaling pathways, master regulators andcell fates may allow yeast communities to respond appropriately to the widerange of environments they encounter in nature.

No MeSH data available.


FIGURE 1: Alternative fates for diploid yeast.S. cerevisiae typically have an ovoid shape whenproliferating (1), and can differentiate to form chains of elongatedpseudohyphal cells (2), rounded quiescent cells that subsequently ageand succumb to programmed cell death (3), or tetrad asci, i.e. fourhaploid spores held together in an ascal sac (4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5134742&req=5

Fig1: FIGURE 1: Alternative fates for diploid yeast.S. cerevisiae typically have an ovoid shape whenproliferating (1), and can differentiate to form chains of elongatedpseudohyphal cells (2), rounded quiescent cells that subsequently ageand succumb to programmed cell death (3), or tetrad asci, i.e. fourhaploid spores held together in an ascal sac (4).


Similar environments but diverse fates: Responses of budding yeast tonutrient deprivation
FIGURE 1: Alternative fates for diploid yeast.S. cerevisiae typically have an ovoid shape whenproliferating (1), and can differentiate to form chains of elongatedpseudohyphal cells (2), rounded quiescent cells that subsequently ageand succumb to programmed cell death (3), or tetrad asci, i.e. fourhaploid spores held together in an ascal sac (4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5134742&req=5

Fig1: FIGURE 1: Alternative fates for diploid yeast.S. cerevisiae typically have an ovoid shape whenproliferating (1), and can differentiate to form chains of elongatedpseudohyphal cells (2), rounded quiescent cells that subsequently ageand succumb to programmed cell death (3), or tetrad asci, i.e. fourhaploid spores held together in an ascal sac (4).

View Article: PubMed Central - PubMed

ABSTRACT

Diploid budding yeast (Saccharomyces cerevisiae) can adopt oneof several alternative differentiation fates in response to nutrient limitation,and each of these fates provides distinct biological functions. When differentstrain backgrounds are taken into account, these various fates occur in responseto similar environmental cues, are regulated by the same signal transductionpathways, and share many of the same master regulators. I propose that therelationships between fate choice, environmental cues and signaling pathways arenot Boolean, but involve graded levels of signals, pathway activation andmaster-regulator activity. In the absence of large differences betweenenvironmental cues, small differences in the concentration of cues may bereinforced by cell-to-cell signals. These signals are particularly essential forfate determination within communities, such as colonies and biofilms, where fatechoice varies dramatically from one region of the community to another. The lackof Boolean relationships between cues, signaling pathways, master regulators andcell fates may allow yeast communities to respond appropriately to the widerange of environments they encounter in nature.

No MeSH data available.