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Application of transrectal ultrasound-guided repeat needle biopsy in the diagnosis of prostate cancer in Chinese population: A retrospective study

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ABSTRACT

Background:: Transrectal ultrasound-guided repeat needle biopsy (TUGRNB) is widely used for diagnosis of prostate cancer (PCa). However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population.

Materials and methods:: A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated. Relationship between prostate specific antigen (PSA) levels and PCa positive rates was analyzed.

Results:: PCa positive detection rate after initial needle biopsy was 28.4%, which was lower than the rate of repeat needle biopsy (40%). The rate for immediate transurethral resection (TUR), surgery after initial needle biopsy, was 27.1%, however with a low PCa positive detection rate (0.66%). The repeat needle biopsy rate was lower compared with the initial biopsy rate (P < 0.05). Meanwhile, immediate TUR rate was significantly higher than that of the repeat needle biopsy rate (P < 0.05). Among the three groups, the PCa positive detection rate in repeat needle biopsy group was the highest. In subgroups with different PSA levels, the PCa positive rate increased with the elevation of PSA level. In cases with PSA > 20 ng/ml, PCa positive rate was significantly higher than those with PSA < 20 ng/ml (P < 0.05).

Conclusion:: PCa positive detection rate following repeat needle biopsy in Chinese population was higher, although the repeated needle biopsy rate was still in a low level. TUGRNB should attract more attention in the diagnosis of PCa.

No MeSH data available.


Related in: MedlinePlus

Pathological characteristics of prostate cancer, (a) prostate cancer; (b) benign prostatic hyperplasia with atypical small acinar proliferation; (c) benign prostatic hyperplasia with prostatic intraepithelial neoplasia; (d) benign prostatic hyperplasia with chronic prostatitis; (e) benign prostatic hyperplasia
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Figure 1: Pathological characteristics of prostate cancer, (a) prostate cancer; (b) benign prostatic hyperplasia with atypical small acinar proliferation; (c) benign prostatic hyperplasia with prostatic intraepithelial neoplasia; (d) benign prostatic hyperplasia with chronic prostatitis; (e) benign prostatic hyperplasia

Mentions: In subgroups of Group 1 with different PSA levels, the PCa positive detection rate increased with the elevation of PSA. In cases with PSA >20 ng/ml, PCa positive rate was significantly higher than those with PSA <20 ng/ml (P < 0.05) [Table 2]. The PSA values in different subgroups with different pathological diagnosis were shown in Figure 1 and Table 3. The PSA values in the five groups underwent ANOVA; significant difference was found when PCa positive group was compared with non-PCa positive groups (P < 0.05).


Application of transrectal ultrasound-guided repeat needle biopsy in the diagnosis of prostate cancer in Chinese population: A retrospective study
Pathological characteristics of prostate cancer, (a) prostate cancer; (b) benign prostatic hyperplasia with atypical small acinar proliferation; (c) benign prostatic hyperplasia with prostatic intraepithelial neoplasia; (d) benign prostatic hyperplasia with chronic prostatitis; (e) benign prostatic hyperplasia
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121991&req=5

Figure 1: Pathological characteristics of prostate cancer, (a) prostate cancer; (b) benign prostatic hyperplasia with atypical small acinar proliferation; (c) benign prostatic hyperplasia with prostatic intraepithelial neoplasia; (d) benign prostatic hyperplasia with chronic prostatitis; (e) benign prostatic hyperplasia
Mentions: In subgroups of Group 1 with different PSA levels, the PCa positive detection rate increased with the elevation of PSA. In cases with PSA >20 ng/ml, PCa positive rate was significantly higher than those with PSA <20 ng/ml (P < 0.05) [Table 2]. The PSA values in different subgroups with different pathological diagnosis were shown in Figure 1 and Table 3. The PSA values in the five groups underwent ANOVA; significant difference was found when PCa positive group was compared with non-PCa positive groups (P < 0.05).

View Article: PubMed Central - PubMed

ABSTRACT

Background:: Transrectal ultrasound-guided repeat needle biopsy (TUGRNB) is widely used for diagnosis of prostate cancer (PCa). However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population.

Materials and methods:: A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated. Relationship between prostate specific antigen (PSA) levels and PCa positive rates was analyzed.

Results:: PCa positive detection rate after initial needle biopsy was 28.4%, which was lower than the rate of repeat needle biopsy (40%). The rate for immediate transurethral resection (TUR), surgery after initial needle biopsy, was 27.1%, however with a low PCa positive detection rate (0.66%). The repeat needle biopsy rate was lower compared with the initial biopsy rate (P &lt; 0.05). Meanwhile, immediate TUR rate was significantly higher than that of the repeat needle biopsy rate (P &lt; 0.05). Among the three groups, the PCa positive detection rate in repeat needle biopsy group was the highest. In subgroups with different PSA levels, the PCa positive rate increased with the elevation of PSA level. In cases with PSA &gt; 20 ng/ml, PCa positive rate was significantly higher than those with PSA &lt; 20 ng/ml (P &lt; 0.05).

Conclusion:: PCa positive detection rate following repeat needle biopsy in Chinese population was higher, although the repeated needle biopsy rate was still in a low level. TUGRNB should attract more attention in the diagnosis of PCa.

No MeSH data available.


Related in: MedlinePlus