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High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma

View Article: PubMed Central - PubMed

ABSTRACT

Guanine nucleotide binding protein alpha 13 (GNA13) has been found to play critical roles in the development of several human cancers. However, little is known about GNA13 expression and its clinical significance in hepatocellular carcinoma (HCC). In our study, GNA13 was reported to be significantly up-regulated in HCC tissues, and this was correlated with several clinicopathological parameters, including tumor multiplicity (P = 0.004), TNM stage (P = 0.002), and BCLC stage (P = 0.010). Further Cox regression analysis suggested that GNA13 expression was an independent prognostic factor for overall survival (P = 0.014) and disease-free survival (P = 0.005). Moreover, we found that overexpression of GNA13 couldn’t promote cell proliferation in vitro, but could significantly increase the invasion ability of HCC cells. Together, our study demonstrates GNA13 may be served as a prognostic biomarker for HCC patients after curative hepatectomy, in which high expression of GNA13 suggests poor prognosis of HCC patients.

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Survival analysis of GNA13 expression by Kaplan-Meier method.Overall survival rate and disease-free survival rate in total (A,B) HCC patients with low/high GNA13 expression. Overall survival rate and disease-free survival rate in tumor size > 5 cm (C,D), TNM stage III/IV (E,F), and pathological grade III/IV (G,H) HCC patients with low/high GNA13 expression.
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f4: Survival analysis of GNA13 expression by Kaplan-Meier method.Overall survival rate and disease-free survival rate in total (A,B) HCC patients with low/high GNA13 expression. Overall survival rate and disease-free survival rate in tumor size > 5 cm (C,D), TNM stage III/IV (E,F), and pathological grade III/IV (G,H) HCC patients with low/high GNA13 expression.

Mentions: The relationship between GNA13 expression in HCC patients and the survival time of these patients was analyzed by Kaplan-Meier analysis and the log-rank test (Fig. 4). The log-rank test showed that the survival time was different between high and low GNA13 expression groups. The median overall survival (OS) time of high GNA13 expression group was 39.1 months, remarkably shorter than that of low GNA13 expression group (48.9 months) (log-rank test, P = 0.003, Fig. 4A). Furthermore, the patients with high GNA13 expression exhibited a significantly shorter DFS than those exhibiting low expression of GNA13 (log-rank test, P = 0.001, Fig. 4B). Moreover, we deployed survival analysis towards the level of GNA13 expression in subgroups of HCC patients against tumor size, TNM stages, and histological grades. Our results revealed that high expression of GNA13 could be a prognostic factor for HCC patients with tumor size >5 cm (OS: P = 0.005, Fig. 4C; DFS: P = 0.002, Fig. 4D), TNM stage III/IV (OS: P = 0.016, Fig. 4E; DFS: P = 0.020, Fig. 4F), and pathological grade III/IV (OS: P = 0.038, Fig. 4G; DFS:P = 0.008, Fig. 4H).


High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma
Survival analysis of GNA13 expression by Kaplan-Meier method.Overall survival rate and disease-free survival rate in total (A,B) HCC patients with low/high GNA13 expression. Overall survival rate and disease-free survival rate in tumor size > 5 cm (C,D), TNM stage III/IV (E,F), and pathological grade III/IV (G,H) HCC patients with low/high GNA13 expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121652&req=5

f4: Survival analysis of GNA13 expression by Kaplan-Meier method.Overall survival rate and disease-free survival rate in total (A,B) HCC patients with low/high GNA13 expression. Overall survival rate and disease-free survival rate in tumor size > 5 cm (C,D), TNM stage III/IV (E,F), and pathological grade III/IV (G,H) HCC patients with low/high GNA13 expression.
Mentions: The relationship between GNA13 expression in HCC patients and the survival time of these patients was analyzed by Kaplan-Meier analysis and the log-rank test (Fig. 4). The log-rank test showed that the survival time was different between high and low GNA13 expression groups. The median overall survival (OS) time of high GNA13 expression group was 39.1 months, remarkably shorter than that of low GNA13 expression group (48.9 months) (log-rank test, P = 0.003, Fig. 4A). Furthermore, the patients with high GNA13 expression exhibited a significantly shorter DFS than those exhibiting low expression of GNA13 (log-rank test, P = 0.001, Fig. 4B). Moreover, we deployed survival analysis towards the level of GNA13 expression in subgroups of HCC patients against tumor size, TNM stages, and histological grades. Our results revealed that high expression of GNA13 could be a prognostic factor for HCC patients with tumor size >5 cm (OS: P = 0.005, Fig. 4C; DFS: P = 0.002, Fig. 4D), TNM stage III/IV (OS: P = 0.016, Fig. 4E; DFS: P = 0.020, Fig. 4F), and pathological grade III/IV (OS: P = 0.038, Fig. 4G; DFS:P = 0.008, Fig. 4H).

View Article: PubMed Central - PubMed

ABSTRACT

Guanine nucleotide binding protein alpha 13 (GNA13) has been found to play critical roles in the development of several human cancers. However, little is known about GNA13 expression and its clinical significance in hepatocellular carcinoma (HCC). In our study, GNA13 was reported to be significantly up-regulated in HCC tissues, and this was correlated with several clinicopathological parameters, including tumor multiplicity (P = 0.004), TNM stage (P = 0.002), and BCLC stage (P = 0.010). Further Cox regression analysis suggested that GNA13 expression was an independent prognostic factor for overall survival (P = 0.014) and disease-free survival (P = 0.005). Moreover, we found that overexpression of GNA13 couldn’t promote cell proliferation in vitro, but could significantly increase the invasion ability of HCC cells. Together, our study demonstrates GNA13 may be served as a prognostic biomarker for HCC patients after curative hepatectomy, in which high expression of GNA13 suggests poor prognosis of HCC patients.

No MeSH data available.


Related in: MedlinePlus