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Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India

View Article: PubMed Central - PubMed

ABSTRACT

The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 diabetes (T2DM, n = 71), coronary artery diseases (CAD, n = 28), T2DM_CAD (n = 38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects. Although all the vitamin D metabolites were significantly decreased in T2DM_CAD as compared to both control and T2DM subjects (p < 0.05), only two metabolites i.e., 25(OH)D3 and total 25(OH)D were significantly (p < 0.05) decreased in the T2DM subjects as compared with the control subjects (p < 0.05). Vitamin D3, 1,25(OH)2D2, 25(OH)D, and 1,25(OH)2D levels were significantly decreased in T2DM_CAD subjects as compared with CAD subjects (p < 0.05). Further, multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM (OR 0.82.95% CI 0.68–0.99; p = 0.0208) and T2DM with CAD (OR 0.460, 95% CI 0.242–0.874; p = 0.0177), respectively. Our data concludes that lower concentration of 1,25(OH)2D is associated with type 2 diabetes coexisting with coronary artery diseases in South Indian subjects.

No MeSH data available.


Scatterplot representing relationship between (A) 25(OH)D and FBS (B) 25(OH)D and HbA1C.
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f6: Scatterplot representing relationship between (A) 25(OH)D and FBS (B) 25(OH)D and HbA1C.

Mentions: Correlation has been measured to show the association between pairs of variables associated. Spearman correlation is examined between 25(OH)D and HbA1c or FBS. Both pairs of variables showed significant negative correlation between 25(OH)D and FBS (r = −0.213; p < 0.001) (Fig. 6A), and 25(OH)D and HbA1c (r = −0.263; p < 0.001) (Fig. 6B). Present study did not show significant association of 25(OH)D with age, BMI, and CK-MB.


Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India
Scatterplot representing relationship between (A) 25(OH)D and FBS (B) 25(OH)D and HbA1C.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121614&req=5

f6: Scatterplot representing relationship between (A) 25(OH)D and FBS (B) 25(OH)D and HbA1C.
Mentions: Correlation has been measured to show the association between pairs of variables associated. Spearman correlation is examined between 25(OH)D and HbA1c or FBS. Both pairs of variables showed significant negative correlation between 25(OH)D and FBS (r = −0.213; p < 0.001) (Fig. 6A), and 25(OH)D and HbA1c (r = −0.263; p < 0.001) (Fig. 6B). Present study did not show significant association of 25(OH)D with age, BMI, and CK-MB.

View Article: PubMed Central - PubMed

ABSTRACT

The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n&thinsp;=&thinsp;50), type 2 diabetes (T2DM, n&thinsp;=&thinsp;71), coronary artery diseases (CAD, n&thinsp;=&thinsp;28), T2DM_CAD (n&thinsp;=&thinsp;38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects. Although all the vitamin D metabolites were significantly decreased in T2DM_CAD as compared to both control and T2DM subjects (p&thinsp;&lt;&thinsp;0.05), only two metabolites i.e., 25(OH)D3 and total 25(OH)D were significantly (p&thinsp;&lt;&thinsp;0.05) decreased in the T2DM subjects as compared with the control subjects (p&thinsp;&lt;&thinsp;0.05). Vitamin D3, 1,25(OH)2D2, 25(OH)D, and 1,25(OH)2D levels were significantly decreased in T2DM_CAD subjects as compared with CAD subjects (p&thinsp;&lt;&thinsp;0.05). Further, multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM (OR 0.82.95% CI 0.68&ndash;0.99; p&thinsp;=&thinsp;0.0208) and T2DM with CAD (OR 0.460, 95% CI 0.242&ndash;0.874; p&thinsp;=&thinsp;0.0177), respectively. Our data concludes that lower concentration of 1,25(OH)2D is associated with type 2 diabetes coexisting with coronary artery diseases in South Indian subjects.

No MeSH data available.