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Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India

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ABSTRACT

The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 diabetes (T2DM, n = 71), coronary artery diseases (CAD, n = 28), T2DM_CAD (n = 38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects. Although all the vitamin D metabolites were significantly decreased in T2DM_CAD as compared to both control and T2DM subjects (p < 0.05), only two metabolites i.e., 25(OH)D3 and total 25(OH)D were significantly (p < 0.05) decreased in the T2DM subjects as compared with the control subjects (p < 0.05). Vitamin D3, 1,25(OH)2D2, 25(OH)D, and 1,25(OH)2D levels were significantly decreased in T2DM_CAD subjects as compared with CAD subjects (p < 0.05). Further, multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM (OR 0.82.95% CI 0.68–0.99; p = 0.0208) and T2DM with CAD (OR 0.460, 95% CI 0.242–0.874; p = 0.0177), respectively. Our data concludes that lower concentration of 1,25(OH)2D is associated with type 2 diabetes coexisting with coronary artery diseases in South Indian subjects.

No MeSH data available.


Serum vitamin D metabolites levels in control, T2DM and T2DM_CAD groups.Serum levels of vitamin D3 (A), 25(OH)D3 (B), 1,25(OH)2D3 (C)vitamin D2 (D), 25(OH)D2 (E), 1,25(OH)2D2 (F) 25(OH)D (G), and 1,25(OH)2D (H) were determined in control, T2DM, and T2DM_CAD groups. Data were expressed as median and interquartile range. p < 0.05 was considered significant.
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f4: Serum vitamin D metabolites levels in control, T2DM and T2DM_CAD groups.Serum levels of vitamin D3 (A), 25(OH)D3 (B), 1,25(OH)2D3 (C)vitamin D2 (D), 25(OH)D2 (E), 1,25(OH)2D2 (F) 25(OH)D (G), and 1,25(OH)2D (H) were determined in control, T2DM, and T2DM_CAD groups. Data were expressed as median and interquartile range. p < 0.05 was considered significant.

Mentions: All six vitamin D metabolites and total 25(OH)D, total 1,25(OH)2D were significantly lowered in T2DM_CAD group as compared to control group (p < 0.05) (Fig. 4A–H). Similarly, all six vitamin D metabolites levels and total 25(OH)D, total 1,25(OH)2D were significantly (p < 0.05) decreased in T2DM_CAD group as compared to T2DM group (Fig. 4A–H). Only serum 25(OH)D3 and 25(OH)D levels were significantly (p < 0.05) lowered in T2DM group as compared to control (Fig. 4B and G). Results from the present study indicates that T2DM_CAD group patients have more severe vitamin D deficiency as reflected by reduction of all vitamin D metabolites levels in blood compared to T2DM group patients.


Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India
Serum vitamin D metabolites levels in control, T2DM and T2DM_CAD groups.Serum levels of vitamin D3 (A), 25(OH)D3 (B), 1,25(OH)2D3 (C)vitamin D2 (D), 25(OH)D2 (E), 1,25(OH)2D2 (F) 25(OH)D (G), and 1,25(OH)2D (H) were determined in control, T2DM, and T2DM_CAD groups. Data were expressed as median and interquartile range. p < 0.05 was considered significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

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f4: Serum vitamin D metabolites levels in control, T2DM and T2DM_CAD groups.Serum levels of vitamin D3 (A), 25(OH)D3 (B), 1,25(OH)2D3 (C)vitamin D2 (D), 25(OH)D2 (E), 1,25(OH)2D2 (F) 25(OH)D (G), and 1,25(OH)2D (H) were determined in control, T2DM, and T2DM_CAD groups. Data were expressed as median and interquartile range. p < 0.05 was considered significant.
Mentions: All six vitamin D metabolites and total 25(OH)D, total 1,25(OH)2D were significantly lowered in T2DM_CAD group as compared to control group (p < 0.05) (Fig. 4A–H). Similarly, all six vitamin D metabolites levels and total 25(OH)D, total 1,25(OH)2D were significantly (p < 0.05) decreased in T2DM_CAD group as compared to T2DM group (Fig. 4A–H). Only serum 25(OH)D3 and 25(OH)D levels were significantly (p < 0.05) lowered in T2DM group as compared to control (Fig. 4B and G). Results from the present study indicates that T2DM_CAD group patients have more severe vitamin D deficiency as reflected by reduction of all vitamin D metabolites levels in blood compared to T2DM group patients.

View Article: PubMed Central - PubMed

ABSTRACT

The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n&thinsp;=&thinsp;50), type 2 diabetes (T2DM, n&thinsp;=&thinsp;71), coronary artery diseases (CAD, n&thinsp;=&thinsp;28), T2DM_CAD (n&thinsp;=&thinsp;38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects. Although all the vitamin D metabolites were significantly decreased in T2DM_CAD as compared to both control and T2DM subjects (p&thinsp;&lt;&thinsp;0.05), only two metabolites i.e., 25(OH)D3 and total 25(OH)D were significantly (p&thinsp;&lt;&thinsp;0.05) decreased in the T2DM subjects as compared with the control subjects (p&thinsp;&lt;&thinsp;0.05). Vitamin D3, 1,25(OH)2D2, 25(OH)D, and 1,25(OH)2D levels were significantly decreased in T2DM_CAD subjects as compared with CAD subjects (p&thinsp;&lt;&thinsp;0.05). Further, multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM (OR 0.82.95% CI 0.68&ndash;0.99; p&thinsp;=&thinsp;0.0208) and T2DM with CAD (OR 0.460, 95% CI 0.242&ndash;0.874; p&thinsp;=&thinsp;0.0177), respectively. Our data concludes that lower concentration of 1,25(OH)2D is associated with type 2 diabetes coexisting with coronary artery diseases in South Indian subjects.

No MeSH data available.