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Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

View Article: PubMed Central - PubMed

ABSTRACT

Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.

No MeSH data available.


Related in: MedlinePlus

a Upper panel: OLP lesions observed on the upper and lower gingivae in the 60-year-old female during her first visit to the clinic (April 2013) (arrows). Lower panel: the OLP lesion was also present on the buccal mucosa, bilaterally (April 2013). b Upper panel: the white spots of OLP became faint and appeared to reduce by SVR35 (June 2016). Lower panel: disappearance of OLP on the buccal mucosa (June 2016). The white arrows show the OLP lesions.
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Figure 1: a Upper panel: OLP lesions observed on the upper and lower gingivae in the 60-year-old female during her first visit to the clinic (April 2013) (arrows). Lower panel: the OLP lesion was also present on the buccal mucosa, bilaterally (April 2013). b Upper panel: the white spots of OLP became faint and appeared to reduce by SVR35 (June 2016). Lower panel: disappearance of OLP on the buccal mucosa (June 2016). The white arrows show the OLP lesions.

Mentions: In April 2013, a 60-year-old Japanese female visited the Misaka dental clinic (Fukuoka, Japan) complaining of gingival discomfort and was diagnosed with periodontitis. During treatment, the dentist and the dental hygienist noticed several white spots on the gingiva (fig 1a). Characteristic white papules were observed on the upper and lower gingivae as well as the buccal mucosae, bilaterally. The lesions were clinically diagnosed as OLP by a specialist oral surgeon. Regular treatment for the periodontal disease reduced the gingival bleeding and swelling; however, the white spots on the gingiva and buccal mucosae did not disappear.


Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report
a Upper panel: OLP lesions observed on the upper and lower gingivae in the 60-year-old female during her first visit to the clinic (April 2013) (arrows). Lower panel: the OLP lesion was also present on the buccal mucosa, bilaterally (April 2013). b Upper panel: the white spots of OLP became faint and appeared to reduce by SVR35 (June 2016). Lower panel: disappearance of OLP on the buccal mucosa (June 2016). The white arrows show the OLP lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121565&req=5

Figure 1: a Upper panel: OLP lesions observed on the upper and lower gingivae in the 60-year-old female during her first visit to the clinic (April 2013) (arrows). Lower panel: the OLP lesion was also present on the buccal mucosa, bilaterally (April 2013). b Upper panel: the white spots of OLP became faint and appeared to reduce by SVR35 (June 2016). Lower panel: disappearance of OLP on the buccal mucosa (June 2016). The white arrows show the OLP lesions.
Mentions: In April 2013, a 60-year-old Japanese female visited the Misaka dental clinic (Fukuoka, Japan) complaining of gingival discomfort and was diagnosed with periodontitis. During treatment, the dentist and the dental hygienist noticed several white spots on the gingiva (fig 1a). Characteristic white papules were observed on the upper and lower gingivae as well as the buccal mucosae, bilaterally. The lesions were clinically diagnosed as OLP by a specialist oral surgeon. Regular treatment for the periodontal disease reduced the gingival bleeding and swelling; however, the white spots on the gingiva and buccal mucosae did not disappear.

View Article: PubMed Central - PubMed

ABSTRACT

Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.

No MeSH data available.


Related in: MedlinePlus