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A Giant Gastrointestinal Stromal Tumor of the Stomach with Extramural Growth

View Article: PubMed Central - PubMed

ABSTRACT

A 76-year-old man presented to our hospital with abdominal distention and loss of appetite. The 10% of weight lost relative to this patient in 1 month. Abdominal computed tomography and magnetic resonance imaging revealed a giant mass, with a major axis of 23 cm, containing solid components, not involving the upper abdominal organs. Esophagogastroduodenoscopy showed extramural compression from the middle gastric body to the antrum, as well as a normal mucosal surface. These findings were suggestive of a gastrointestinal stromal tumor attached to the anterior wall of the stomach without metastasis or invasion. Partial gastrectomy was performed for tumor resection, and the patient was subsequently treated with adjuvant imatinib. We report a rare case of a large extramural gastrointestinal stromal tumor of the stomach that was larger than 20 cm in diameter and present a pertinent literature review.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin stained section indicated that cells with spindle-shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below the muscularis propria of the stomach (a). Immunohistochemistry results indicated that tumor cells were CD117 (C-kit) (+) (b) and CD34 (+) (c). Negative control staining for the immunohistochemistry were S-100(–) (d) and α-SMA(–) (e).
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Figure 3: Hematoxylin and eosin stained section indicated that cells with spindle-shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below the muscularis propria of the stomach (a). Immunohistochemistry results indicated that tumor cells were CD117 (C-kit) (+) (b) and CD34 (+) (c). Negative control staining for the immunohistochemistry were S-100(–) (d) and α-SMA(–) (e).

Mentions: Histopathological findings indicated that tumor cells were spindle shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below muscularis propria of the stomach. Karyokinesis count was 7–8/HPF (400 × 10 field mean value). On immunohistochemistry, the tumor cells were indicated to be CD117 (C-kit)(+), CD34(+), S-100(–), α-SMA (α-smooth muscle actin)(–), and desmin(–) (fig. 3). The Ki67 positivity rate was approximately 40%. No metastatic lesions were noted in the greater omentum. Thus, a diagnosis of classical GIST was made, and the tumor was classified into the high-risk group due to the high karyokinesis count and larger diameter.


A Giant Gastrointestinal Stromal Tumor of the Stomach with Extramural Growth
Hematoxylin and eosin stained section indicated that cells with spindle-shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below the muscularis propria of the stomach (a). Immunohistochemistry results indicated that tumor cells were CD117 (C-kit) (+) (b) and CD34 (+) (c). Negative control staining for the immunohistochemistry were S-100(–) (d) and α-SMA(–) (e).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121561&req=5

Figure 3: Hematoxylin and eosin stained section indicated that cells with spindle-shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below the muscularis propria of the stomach (a). Immunohistochemistry results indicated that tumor cells were CD117 (C-kit) (+) (b) and CD34 (+) (c). Negative control staining for the immunohistochemistry were S-100(–) (d) and α-SMA(–) (e).
Mentions: Histopathological findings indicated that tumor cells were spindle shaped and oval nuclei exhibited tight, intricate hyperplasia in bundles below muscularis propria of the stomach. Karyokinesis count was 7–8/HPF (400 × 10 field mean value). On immunohistochemistry, the tumor cells were indicated to be CD117 (C-kit)(+), CD34(+), S-100(–), α-SMA (α-smooth muscle actin)(–), and desmin(–) (fig. 3). The Ki67 positivity rate was approximately 40%. No metastatic lesions were noted in the greater omentum. Thus, a diagnosis of classical GIST was made, and the tumor was classified into the high-risk group due to the high karyokinesis count and larger diameter.

View Article: PubMed Central - PubMed

ABSTRACT

A 76-year-old man presented to our hospital with abdominal distention and loss of appetite. The 10% of weight lost relative to this patient in 1 month. Abdominal computed tomography and magnetic resonance imaging revealed a giant mass, with a major axis of 23 cm, containing solid components, not involving the upper abdominal organs. Esophagogastroduodenoscopy showed extramural compression from the middle gastric body to the antrum, as well as a normal mucosal surface. These findings were suggestive of a gastrointestinal stromal tumor attached to the anterior wall of the stomach without metastasis or invasion. Partial gastrectomy was performed for tumor resection, and the patient was subsequently treated with adjuvant imatinib. We report a rare case of a large extramural gastrointestinal stromal tumor of the stomach that was larger than 20 cm in diameter and present a pertinent literature review.

No MeSH data available.


Related in: MedlinePlus