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Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease ( GWTG ‐ CAD ) Registry

View Article: PubMed Central - PubMed

ABSTRACT

Background: Timely reperfusion after ST‐elevation myocardial infarction (STEMI) improves survival. Guidelines recommend primary percutaneous coronary intervention (PPCI) within 90 minutes of arrival at a PCI‐capable hospital. The alternative is fibrinolysis within 30 minutes for those in those for whom timely transfer to a PCI‐capable hospital is not feasible.

Methods and results: We identified STEMI patients receiving reperfusion therapy at 229 hospitals participating in the Get With the Guidelines—Coronary Artery Disease (GWTG‐CAD) database (January 1, 2003 through December 31, 2008). Temporal trends in the use of fibrinolysis and PPCI, its timeliness, and in‐hospital mortality outcomes were assessed. We also assessed predictors of fibrinolysis versus PPCI and compliance with performance measures. Defect‐free care was defined as 100% compliance with all performance measures. We identified 29 190 STEMI patients, of whom 2441 (8.4%) received fibrinolysis; 38.2% of these patients achieved door‐to‐needle times ≤30 minutes. Median door‐to‐needle times increased from 36 to 60 minutes (P=0.005) over the study period. Among PPCI patients, median door‐to‐balloon times decreased from 94 to 64 minutes (P<0.0001) over the same period. In‐hospital mortality was higher with fibrinolysis than with PPCI (4.6% vs 3.3%, P=0.001) and did not change significantly over time. Patients receiving fibrinolysis were less likely to receive defect‐free care compared with their PPCI counterparts.

Conclusions: Use of fibrinolysis for STEMI has decreased over time with concomitant worsening of door‐to‐needle times. Over the same time period, use of PPCI increased with improvement in door‐to‐balloon times. In‐hospital mortality was higher with fibrinolysis than with PPCI. As reperfusion for STEMI continues to shift from fibrinolysis to PPCI, it will be critical to ensure that door‐to‐needle times and outcomes do not worsen.

No MeSH data available.


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Study cohort development and exclusions. STEMI indicates ST elevation myocardial infarction.
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jah31817-fig-0001: Study cohort development and exclusions. STEMI indicates ST elevation myocardial infarction.

Mentions: Between January 1, 2003 and December 31, 2008, data were available on 238 465 patients enrolled from 415 hospitals participating in the GWTG‐CAD program who were hospitalized with a confirmed clinical diagnosis of CAD—including patients with acute coronary syndromes, those with stable CAD hospitalized for revascularization, and those with documented CAD hospitalized for reasons other than heart failure. Hospitals with >25% missing from the medical history panel and patients with unrecorded sex were excluded from the analyses. Patients were excluded if they were not diagnosed with STEMI, did not receive fibrinolysis or primary PCI, had missing discharge status, were transferred to another acute care facility, or left against medical advice (Figure 1). Sites with fewer than 5 patients after the prior exclusions were also excluded. Following these exclusions, our study population consisted of 29 190 STEMI patients from 229 sites.


Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease ( GWTG ‐ CAD ) Registry
Study cohort development and exclusions. STEMI indicates ST elevation myocardial infarction.
© Copyright Policy - creativeCommonsBy-nc
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121508&req=5

jah31817-fig-0001: Study cohort development and exclusions. STEMI indicates ST elevation myocardial infarction.
Mentions: Between January 1, 2003 and December 31, 2008, data were available on 238 465 patients enrolled from 415 hospitals participating in the GWTG‐CAD program who were hospitalized with a confirmed clinical diagnosis of CAD—including patients with acute coronary syndromes, those with stable CAD hospitalized for revascularization, and those with documented CAD hospitalized for reasons other than heart failure. Hospitals with >25% missing from the medical history panel and patients with unrecorded sex were excluded from the analyses. Patients were excluded if they were not diagnosed with STEMI, did not receive fibrinolysis or primary PCI, had missing discharge status, were transferred to another acute care facility, or left against medical advice (Figure 1). Sites with fewer than 5 patients after the prior exclusions were also excluded. Following these exclusions, our study population consisted of 29 190 STEMI patients from 229 sites.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Timely reperfusion after ST‐elevation myocardial infarction (STEMI) improves survival. Guidelines recommend primary percutaneous coronary intervention (PPCI) within 90 minutes of arrival at a PCI‐capable hospital. The alternative is fibrinolysis within 30 minutes for those in those for whom timely transfer to a PCI‐capable hospital is not feasible.

Methods and results: We identified STEMI patients receiving reperfusion therapy at 229 hospitals participating in the Get With the Guidelines—Coronary Artery Disease (GWTG‐CAD) database (January 1, 2003 through December 31, 2008). Temporal trends in the use of fibrinolysis and PPCI, its timeliness, and in‐hospital mortality outcomes were assessed. We also assessed predictors of fibrinolysis versus PPCI and compliance with performance measures. Defect‐free care was defined as 100% compliance with all performance measures. We identified 29 190 STEMI patients, of whom 2441 (8.4%) received fibrinolysis; 38.2% of these patients achieved door‐to‐needle times ≤30 minutes. Median door‐to‐needle times increased from 36 to 60 minutes (P=0.005) over the study period. Among PPCI patients, median door‐to‐balloon times decreased from 94 to 64 minutes (P<0.0001) over the same period. In‐hospital mortality was higher with fibrinolysis than with PPCI (4.6% vs 3.3%, P=0.001) and did not change significantly over time. Patients receiving fibrinolysis were less likely to receive defect‐free care compared with their PPCI counterparts.

Conclusions: Use of fibrinolysis for STEMI has decreased over time with concomitant worsening of door‐to‐needle times. Over the same time period, use of PPCI increased with improvement in door‐to‐balloon times. In‐hospital mortality was higher with fibrinolysis than with PPCI. As reperfusion for STEMI continues to shift from fibrinolysis to PPCI, it will be critical to ensure that door‐to‐needle times and outcomes do not worsen.

No MeSH data available.


Related in: MedlinePlus