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Body Composition in Adult Patients with Thalassemia Major

View Article: PubMed Central - PubMed

ABSTRACT

Objective. To assess body composition in adult male and female patients with thalassemia major by dual-energy X-ray absorptiometry (DXA) and to compare the findings with a group of healthy age-matched controls. Methods. Our study group included sixty-two patients (27 males, mean age 36 years, and 35 females, mean age 36.4 years) and fifteen age-matched healthy controls. All patients had an established diagnosis of thalassemia major and followed a regular blood transfusion scheme since childhood and chelation treatment. Fat, lean, and bone mineral density (BMD) were assessed with dual-energy X-ray absorptiometry. Ferritin levels and body mass index of all patients and controls were also recorded. Student t-test and Wilcoxon test were performed and statistical significance was set at p < 0.05. Results. BMD and whole body lean mass are lower in both male and female adult patients compared with controls (p < 0.01 in both groups), whereas whole body fat mass was found to have no statistically significant difference compared to controls. Regional trunk fat around the abdomen was found to be lower in male patients compared to controls (p = 0.02). Conclusion. Severe bone loss and diminished lean mass are expected in adult male and female patients with thalassemia major. Fat changes seem to affect mainly male patients.

No MeSH data available.


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Percentage of regional trunk fat determined with DXA in male and female patients with thalassemia major compared with controls. There is a statistically significant difference in the male group (p = 0.02) but there is no difference in the female group of patients.
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fig2: Percentage of regional trunk fat determined with DXA in male and female patients with thalassemia major compared with controls. There is a statistically significant difference in the male group (p = 0.02) but there is no difference in the female group of patients.

Mentions: The overall fat, expressed in whole body fat percentage and in Kg, is lower in male patients with thalassemia major compared to controls but is not showing a statistical effect (p = 0.07). Likewise, the whole body fat in women shows no difference between patients and controls (p = 0.89). Regarding the regional fat around the abdomen that was expressed as trunk fat percentage, male patients were found to have statistically significantly less fat compared to controls (p = 0.02), whereas no difference was observed between female patients and controls. The whole body lean mass was found to be severely diminished in both male and female groups, compared to controls (p < 0.01 for males and females, resp.) (Figures 2 and 3).


Body Composition in Adult Patients with Thalassemia Major
Percentage of regional trunk fat determined with DXA in male and female patients with thalassemia major compared with controls. There is a statistically significant difference in the male group (p = 0.02) but there is no difference in the female group of patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5121445&req=5

fig2: Percentage of regional trunk fat determined with DXA in male and female patients with thalassemia major compared with controls. There is a statistically significant difference in the male group (p = 0.02) but there is no difference in the female group of patients.
Mentions: The overall fat, expressed in whole body fat percentage and in Kg, is lower in male patients with thalassemia major compared to controls but is not showing a statistical effect (p = 0.07). Likewise, the whole body fat in women shows no difference between patients and controls (p = 0.89). Regarding the regional fat around the abdomen that was expressed as trunk fat percentage, male patients were found to have statistically significantly less fat compared to controls (p = 0.02), whereas no difference was observed between female patients and controls. The whole body lean mass was found to be severely diminished in both male and female groups, compared to controls (p < 0.01 for males and females, resp.) (Figures 2 and 3).

View Article: PubMed Central - PubMed

ABSTRACT

Objective. To assess body composition in adult male and female patients with thalassemia major by dual-energy X-ray absorptiometry (DXA) and to compare the findings with a group of healthy age-matched controls. Methods. Our study group included sixty-two patients (27 males, mean age 36 years, and 35 females, mean age 36.4 years) and fifteen age-matched healthy controls. All patients had an established diagnosis of thalassemia major and followed a regular blood transfusion scheme since childhood and chelation treatment. Fat, lean, and bone mineral density (BMD) were assessed with dual-energy X-ray absorptiometry. Ferritin levels and body mass index of all patients and controls were also recorded. Student t-test and Wilcoxon test were performed and statistical significance was set at p &lt; 0.05. Results. BMD and whole body lean mass are lower in both male and female adult patients compared with controls (p &lt; 0.01 in both groups), whereas whole body fat mass was found to have no statistically significant difference compared to controls. Regional trunk fat around the abdomen was found to be lower in male patients compared to controls (p = 0.02). Conclusion. Severe bone loss and diminished lean mass are expected in adult male and female patients with thalassemia major. Fat changes seem to affect mainly male patients.

No MeSH data available.


Related in: MedlinePlus