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Acute fibrinous and organizing pneumonia in a patient with Sjogren ’ s syndrome

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ABSTRACT

Acute fibrinous and organizing pneumonia (AFOP) is a histological pattern characterized by intra-alveolar fibrin deposition and associated organizing pneumonia. AFOP has been associated with many rheumatologic disorders in the literature but has not been described in association with Sjogren's syndrome.

This paper shows a rare association of AFOP with Sjogren's syndrome. Patient's symptoms promptly improved after treatment with steroid.

No MeSH data available.


Related in: MedlinePlus

Organizing pneumonia with focal intra-alveolar fibrin (hematoxylin-eosin, original magnification ×200).
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fig4: Organizing pneumonia with focal intra-alveolar fibrin (hematoxylin-eosin, original magnification ×200).

Mentions: She was started of vancomycin, cepefime and azithromycin for possible pneumonia. She underwent bronchoscopy on hospital day 3, bronchioalveolar lavage (BAL) and transbronchial biopsy was done at the time. BAL showed presence of alveola macrophages, reactive pneumocytes with rare neutrophils and lymphocytes. Transbronchial biospsy revealed fragments of lung parenchyma with focal areas of organization with intraalveolar fibrin accumulation, reactive type II pneumocyte hyperplasia and associated focal acute and chronic inflammation. These were consistent with the diagnosis of acute fibrinous and organizing pneumonia (Fig. 3, Fig. 4).


Acute fibrinous and organizing pneumonia in a patient with Sjogren ’ s syndrome
Organizing pneumonia with focal intra-alveolar fibrin (hematoxylin-eosin, original magnification ×200).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121161&req=5

fig4: Organizing pneumonia with focal intra-alveolar fibrin (hematoxylin-eosin, original magnification ×200).
Mentions: She was started of vancomycin, cepefime and azithromycin for possible pneumonia. She underwent bronchoscopy on hospital day 3, bronchioalveolar lavage (BAL) and transbronchial biopsy was done at the time. BAL showed presence of alveola macrophages, reactive pneumocytes with rare neutrophils and lymphocytes. Transbronchial biospsy revealed fragments of lung parenchyma with focal areas of organization with intraalveolar fibrin accumulation, reactive type II pneumocyte hyperplasia and associated focal acute and chronic inflammation. These were consistent with the diagnosis of acute fibrinous and organizing pneumonia (Fig. 3, Fig. 4).

View Article: PubMed Central - PubMed

ABSTRACT

Acute fibrinous and organizing pneumonia (AFOP) is a histological pattern characterized by intra-alveolar fibrin deposition and associated organizing pneumonia. AFOP has been associated with many rheumatologic disorders in the literature but has not been described in association with Sjogren's syndrome.

This paper shows a rare association of AFOP with Sjogren's syndrome. Patient's symptoms promptly improved after treatment with steroid.

No MeSH data available.


Related in: MedlinePlus