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Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions

View Article: PubMed Central - PubMed

ABSTRACT

Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between “younger” and “older” onset MS subjects who were matched for short disease duration, mean 1.9 years and burden as measured by the MS Severity Score and relapses.

21 younger-onset MS subjects (age 30.4 ± 3.2 years) were compared with 17 older-onset (age 48.7 ± 3.3 years) as well as age-matched controls (n = 31, 31.9 ± 3.5 years and n = 21, 47.3 ± 4.0 years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors.

Volume loss versus control was predominantly in the subcortical GM, at > 13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (p < 0.001) and a strong trend in the older-onset group.

These results provide a potential imaging correlate of published neuropsychological studies that reported the association of younger age at disease onset with impaired cognitive performance, including decreased working memory.

No MeSH data available.


Local tissue volume differences for MS patients. Local (subcortical) GM volume differences for the younger and older MS patients, (A) raw values in mm3 and (B) expressed as a percentage change from the corresponding control group mean tissue volumes. (**) p < 0.01, (***) p < 0.001, ANCOVA of normalized volumes versus age-matched control group. p-Values uncorrected; (†)survives Bonferroni correction for comparisons amongst groups or (‡) regions of interest.
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f0025: Local tissue volume differences for MS patients. Local (subcortical) GM volume differences for the younger and older MS patients, (A) raw values in mm3 and (B) expressed as a percentage change from the corresponding control group mean tissue volumes. (**) p < 0.01, (***) p < 0.001, ANCOVA of normalized volumes versus age-matched control group. p-Values uncorrected; (†)survives Bonferroni correction for comparisons amongst groups or (‡) regions of interest.

Mentions: Local (subcortical) GM tissue volumes and ANCOVA results for comparisons across the four groups are presented in the lower two-thirds of Table 2, with atrophy measures (expressed as the percentage change in mean volume relative to the corresponding control group) shown in Fig. 5. Both the younger and older MS patients had significantly reduced local GM volume compared with the age-matched controls in the region of the putamen (p < 0.001 for both), thalamus (p < = 0.001 for both) and nucleus accumbens (p < 0.001 for younger, p = 0.005 for older MS patients). In two regions – the caudate and the hippocampus - there was significantly reduced GM volume for only the younger MS patients (p < 0.001 for both). The volumes of the amygdala and the pallidum were not significantly different between the MS patients and their age-matched control group (Table 2).


Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions
Local tissue volume differences for MS patients. Local (subcortical) GM volume differences for the younger and older MS patients, (A) raw values in mm3 and (B) expressed as a percentage change from the corresponding control group mean tissue volumes. (**) p < 0.01, (***) p < 0.001, ANCOVA of normalized volumes versus age-matched control group. p-Values uncorrected; (†)survives Bonferroni correction for comparisons amongst groups or (‡) regions of interest.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5121150&req=5

f0025: Local tissue volume differences for MS patients. Local (subcortical) GM volume differences for the younger and older MS patients, (A) raw values in mm3 and (B) expressed as a percentage change from the corresponding control group mean tissue volumes. (**) p < 0.01, (***) p < 0.001, ANCOVA of normalized volumes versus age-matched control group. p-Values uncorrected; (†)survives Bonferroni correction for comparisons amongst groups or (‡) regions of interest.
Mentions: Local (subcortical) GM tissue volumes and ANCOVA results for comparisons across the four groups are presented in the lower two-thirds of Table 2, with atrophy measures (expressed as the percentage change in mean volume relative to the corresponding control group) shown in Fig. 5. Both the younger and older MS patients had significantly reduced local GM volume compared with the age-matched controls in the region of the putamen (p < 0.001 for both), thalamus (p < = 0.001 for both) and nucleus accumbens (p < 0.001 for younger, p = 0.005 for older MS patients). In two regions – the caudate and the hippocampus - there was significantly reduced GM volume for only the younger MS patients (p < 0.001 for both). The volumes of the amygdala and the pallidum were not significantly different between the MS patients and their age-matched control group (Table 2).

View Article: PubMed Central - PubMed

ABSTRACT

Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between &ldquo;younger&rdquo; and &ldquo;older&rdquo; onset MS subjects who were matched for short disease duration, mean 1.9&nbsp;years and burden as measured by the MS Severity Score and relapses.

21 younger-onset MS subjects (age 30.4&nbsp;&plusmn;&nbsp;3.2&nbsp;years) were compared with 17 older-onset (age 48.7&nbsp;&plusmn;&nbsp;3.3&nbsp;years) as well as age-matched controls (n&nbsp;=&nbsp;31, 31.9&nbsp;&plusmn;&nbsp;3.5&nbsp;years and n&nbsp;=&nbsp;21, 47.3&nbsp;&plusmn;&nbsp;4.0&nbsp;years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors.

Volume loss versus control was predominantly in the subcortical GM, at &gt;&nbsp;13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (p&nbsp;&lt;&nbsp;0.001) and a strong trend in the older-onset group.

These results provide a potential imaging correlate of published neuropsychological studies that reported the association of younger age at disease onset with impaired cognitive performance, including decreased working memory.

No MeSH data available.