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Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions

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ABSTRACT

Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between “younger” and “older” onset MS subjects who were matched for short disease duration, mean 1.9 years and burden as measured by the MS Severity Score and relapses.

21 younger-onset MS subjects (age 30.4 ± 3.2 years) were compared with 17 older-onset (age 48.7 ± 3.3 years) as well as age-matched controls (n = 31, 31.9 ± 3.5 years and n = 21, 47.3 ± 4.0 years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors.

Volume loss versus control was predominantly in the subcortical GM, at > 13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (p < 0.001) and a strong trend in the older-onset group.

These results provide a potential imaging correlate of published neuropsychological studies that reported the association of younger age at disease onset with impaired cognitive performance, including decreased working memory.

No MeSH data available.


Global tissue volumes: four groups. A: global tissue volumes for both age groups of the controls and the MS patients. B: volume difference for the MS global tissue volumes, expressed as a percentage change from the corresponding control group mean tissue volume. Error bars are standard deviations. (***) p ≤ 0.001, uncorrected. (†) survives Bonferroni correction.
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f0020: Global tissue volumes: four groups. A: global tissue volumes for both age groups of the controls and the MS patients. B: volume difference for the MS global tissue volumes, expressed as a percentage change from the corresponding control group mean tissue volume. Error bars are standard deviations. (***) p ≤ 0.001, uncorrected. (†) survives Bonferroni correction.

Mentions: Investigating differences within each age group, the plots in Fig. 4a and the data in the top third of Table 2 reveal significant GM and scGM volume differences between age-matched MS patients and controls (younger: p < 0.001 for both GM and scGM; older: p = 0.001 for GM, p < 0.001 for scGM), whilst there is no significant difference between age-matched patients and controls for the WM and the cGM global tissue volumes. Additionally, Fig. 4b reveals that the percentage decreases in mean global tissue volumes relative to controls are comparable for the younger and the older MS group (WM: − 2.72% and − 2.78%; GM: − 5.86% and − 6.08%; cGM: − 3.73% and − 3.99%; scGM: − 13.01% and − 13.18%, respectively). Once again, the greatest atrophy is found in the scGM global tissue volume, explored further by the evaluation of the local (subcortical) tissue volumes below.


Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions
Global tissue volumes: four groups. A: global tissue volumes for both age groups of the controls and the MS patients. B: volume difference for the MS global tissue volumes, expressed as a percentage change from the corresponding control group mean tissue volume. Error bars are standard deviations. (***) p ≤ 0.001, uncorrected. (†) survives Bonferroni correction.
© Copyright Policy - CC BY
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5121150&req=5

f0020: Global tissue volumes: four groups. A: global tissue volumes for both age groups of the controls and the MS patients. B: volume difference for the MS global tissue volumes, expressed as a percentage change from the corresponding control group mean tissue volume. Error bars are standard deviations. (***) p ≤ 0.001, uncorrected. (†) survives Bonferroni correction.
Mentions: Investigating differences within each age group, the plots in Fig. 4a and the data in the top third of Table 2 reveal significant GM and scGM volume differences between age-matched MS patients and controls (younger: p < 0.001 for both GM and scGM; older: p = 0.001 for GM, p < 0.001 for scGM), whilst there is no significant difference between age-matched patients and controls for the WM and the cGM global tissue volumes. Additionally, Fig. 4b reveals that the percentage decreases in mean global tissue volumes relative to controls are comparable for the younger and the older MS group (WM: − 2.72% and − 2.78%; GM: − 5.86% and − 6.08%; cGM: − 3.73% and − 3.99%; scGM: − 13.01% and − 13.18%, respectively). Once again, the greatest atrophy is found in the scGM global tissue volume, explored further by the evaluation of the local (subcortical) tissue volumes below.

View Article: PubMed Central - PubMed

ABSTRACT

Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between &ldquo;younger&rdquo; and &ldquo;older&rdquo; onset MS subjects who were matched for short disease duration, mean 1.9&nbsp;years and burden as measured by the MS Severity Score and relapses.

21 younger-onset MS subjects (age 30.4&nbsp;&plusmn;&nbsp;3.2&nbsp;years) were compared with 17 older-onset (age 48.7&nbsp;&plusmn;&nbsp;3.3&nbsp;years) as well as age-matched controls (n&nbsp;=&nbsp;31, 31.9&nbsp;&plusmn;&nbsp;3.5&nbsp;years and n&nbsp;=&nbsp;21, 47.3&nbsp;&plusmn;&nbsp;4.0&nbsp;years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors.

Volume loss versus control was predominantly in the subcortical GM, at &gt;&nbsp;13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (p&nbsp;&lt;&nbsp;0.001) and a strong trend in the older-onset group.

These results provide a potential imaging correlate of published neuropsychological studies that reported the association of younger age at disease onset with impaired cognitive performance, including decreased working memory.

No MeSH data available.