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Effect of age and sex on retinal layer thickness and volume in normal eyes

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the study was to evaluate the effect of sex and age on the thickness of the retinal layer in normal eyes using spectral-domain optical coherence tomography (SD-OCT).

Fifty healthy subjects between the ages of 20 and 80 had their retinal layers measured using SD-OCT at Seoul St. Mary's Hospital. Mean thickness and volume were measured for 9 retinal layers in the fovea, the pericentral ring, and the peripheral ring. The differences of sex- and age-related thickness and volume in each retinal layer were analyzed.

The retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) were thinnest in the fovea area, whereas the outer nuclear layer (ONL), photoreceptor layer (PHL), and retinal pigment epithelium (RPE) were thickest at similar locations. Mean thickness of the RNFL, GCL, IPL, and OPL was significantly greater in men than women. However, mean thickness of the ONL was greater in women than in men. When compared between patients < 30 years and > 60 years of age, the thickness and volume of peripheral RNFL, GCL, and pericentral and peripheral IPL were significantly larger in the younger group than the older group. Conversely, the thickness and volume of foveal INL and IR were larger in the older group than in the younger group.

The thickness and volume of the retinal layer in normal eyes significantly vary depending on age and sex. These results should be considered when evaluating layer analysis in retinal disease.

No MeSH data available.


Related in: MedlinePlus

Normal retinal segmentation in SD-OCT. Nine retinal layers were identified by automatic segmentation: retinal nerve fiber layer (layer 1), ganglion cell layer (layer 2), inner plexiform layer (layer 3), inner nuclear layer (layer 4), outer plexiform layer (layer 5), outer nuclear layer (layer 6), inner retina layer (from internal limiting membrane to external limiting membrane) (layer 7), photoreceptor layer (layer 8), and retinal pigment epithelium (layer 9). SD-OCT = spectral-domain optical coherence tomography.
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Figure 1: Normal retinal segmentation in SD-OCT. Nine retinal layers were identified by automatic segmentation: retinal nerve fiber layer (layer 1), ganglion cell layer (layer 2), inner plexiform layer (layer 3), inner nuclear layer (layer 4), outer plexiform layer (layer 5), outer nuclear layer (layer 6), inner retina layer (from internal limiting membrane to external limiting membrane) (layer 7), photoreceptor layer (layer 8), and retinal pigment epithelium (layer 9). SD-OCT = spectral-domain optical coherence tomography.

Mentions: OCT images then underwent automated segmentation of individual retinal layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), inner retina (IR, from internal limiting membrane to external limiting membrane), photoreceptor layer (PHL), and retinal pigment epithelium (RPE)[12] (Fig. 1). In this study, 3 retinal areas were demonstrated according to this Early Treatment Diabetic Retinopathy Study (ETDRS) grid: the fovea, the central circle with a diameter of 1 mm; the pericentral ring, 1 to 3 mm from the center of the fovea; and the peripheral ring, 3 to 6 mm from the center of the fovea (Fig. 2). Automated measurement of their mean macular thickness and volume was done in 9 separate areas based on ETDRS sectors. The mean macular thickness and volume of each retinal layer was measured at the fovea and 4 sectors (superior, inferior, nasal, and temporal) of the pericentral and peripheral rings. The mean thicknesses of the pericentral and peripheral rings were measured by averaging the thickness measurements of the 4 corresponding quadrant areas (segments 2 to 5 for the pericentral ring and segments 6 to 9 for the peripheral ring). Total macular thickness of all areas within the ETDRS grid was automatically calculated by summation of the 9 sectors.


Effect of age and sex on retinal layer thickness and volume in normal eyes
Normal retinal segmentation in SD-OCT. Nine retinal layers were identified by automatic segmentation: retinal nerve fiber layer (layer 1), ganglion cell layer (layer 2), inner plexiform layer (layer 3), inner nuclear layer (layer 4), outer plexiform layer (layer 5), outer nuclear layer (layer 6), inner retina layer (from internal limiting membrane to external limiting membrane) (layer 7), photoreceptor layer (layer 8), and retinal pigment epithelium (layer 9). SD-OCT = spectral-domain optical coherence tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120948&req=5

Figure 1: Normal retinal segmentation in SD-OCT. Nine retinal layers were identified by automatic segmentation: retinal nerve fiber layer (layer 1), ganglion cell layer (layer 2), inner plexiform layer (layer 3), inner nuclear layer (layer 4), outer plexiform layer (layer 5), outer nuclear layer (layer 6), inner retina layer (from internal limiting membrane to external limiting membrane) (layer 7), photoreceptor layer (layer 8), and retinal pigment epithelium (layer 9). SD-OCT = spectral-domain optical coherence tomography.
Mentions: OCT images then underwent automated segmentation of individual retinal layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), inner retina (IR, from internal limiting membrane to external limiting membrane), photoreceptor layer (PHL), and retinal pigment epithelium (RPE)[12] (Fig. 1). In this study, 3 retinal areas were demonstrated according to this Early Treatment Diabetic Retinopathy Study (ETDRS) grid: the fovea, the central circle with a diameter of 1 mm; the pericentral ring, 1 to 3 mm from the center of the fovea; and the peripheral ring, 3 to 6 mm from the center of the fovea (Fig. 2). Automated measurement of their mean macular thickness and volume was done in 9 separate areas based on ETDRS sectors. The mean macular thickness and volume of each retinal layer was measured at the fovea and 4 sectors (superior, inferior, nasal, and temporal) of the pericentral and peripheral rings. The mean thicknesses of the pericentral and peripheral rings were measured by averaging the thickness measurements of the 4 corresponding quadrant areas (segments 2 to 5 for the pericentral ring and segments 6 to 9 for the peripheral ring). Total macular thickness of all areas within the ETDRS grid was automatically calculated by summation of the 9 sectors.

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the study was to evaluate the effect of sex and age on the thickness of the retinal layer in normal eyes using spectral-domain optical coherence tomography (SD-OCT).

Fifty healthy subjects between the ages of 20 and 80 had their retinal layers measured using SD-OCT at Seoul St. Mary's Hospital. Mean thickness and volume were measured for 9 retinal layers in the fovea, the pericentral ring, and the peripheral ring. The differences of sex- and age-related thickness and volume in each retinal layer were analyzed.

The retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) were thinnest in the fovea area, whereas the outer nuclear layer (ONL), photoreceptor layer (PHL), and retinal pigment epithelium (RPE) were thickest at similar locations. Mean thickness of the RNFL, GCL, IPL, and OPL was significantly greater in men than women. However, mean thickness of the ONL was greater in women than in men. When compared between patients < 30 years and > 60 years of age, the thickness and volume of peripheral RNFL, GCL, and pericentral and peripheral IPL were significantly larger in the younger group than the older group. Conversely, the thickness and volume of foveal INL and IR were larger in the older group than in the younger group.

The thickness and volume of the retinal layer in normal eyes significantly vary depending on age and sex. These results should be considered when evaluating layer analysis in retinal disease.

No MeSH data available.


Related in: MedlinePlus