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Diagnosis and treatment of gastrointestinal stromal tumor extending to prostate

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ABSTRACT

Rationale:: Gastrointestinal stromal tumor (GIST) is the neoplasm of gastrointestinal tract.

Patient concerns:: The patient complained about the retention of urinary.

Diagnoses:: GIST.

Interventions:: radical prostatectomy and the imatinib therapy.

Outcomes:: No recurrence and metastasis have been found during a 14-month follow-up.

Lessons:: comprehensive treatment is necessary for the GIST treatment. Furthermore, we summarize a review of the literature of GIST occurring in the prostate gland treated by different methods and 4 kinds of rare diseases in prostate.

No MeSH data available.


Related in: MedlinePlus

Pathologic analysis of the gastrointestinal stromal tumor (GIST). Immunohistochemical stainings of GIST (all 200×) showed negative immunohistochemical stainings of CD31 (A) and CK (B), positive stainings of caldeds (C), CD34 (D), DOG-1 (E), EMA (F), vim (G), CD117 (H). CK = cytokeratin.
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Figure 2: Pathologic analysis of the gastrointestinal stromal tumor (GIST). Immunohistochemical stainings of GIST (all 200×) showed negative immunohistochemical stainings of CD31 (A) and CK (B), positive stainings of caldeds (C), CD34 (D), DOG-1 (E), EMA (F), vim (G), CD117 (H). CK = cytokeratin.

Mentions: The ultrasound colonoscopy and imaging features are shown in Fig. 1. The tumor resected was proved to be GIST pathologically. The tumor cells diffusely and strongly expressed CD117, CD34, Vim, DOG1, CalDes, and the nidus expressed the protein EMA locally (Fig. 2). It also showed Ki-67 labeling rates of 1% and no desmin (DES), glial fibrillary acidic protein (GFAP), cytokeratin, muscle-specific actin (MSA), smooth muscle actin (SMA), and S100 were expressed in the tissue pathologic analysis. The resection margins were free of tumor cells histologically. No urinary dysfunction and injury were observed postsurgically. No local recurrence or distant metastasis was observed during the 14-month follow-up.


Diagnosis and treatment of gastrointestinal stromal tumor extending to prostate
Pathologic analysis of the gastrointestinal stromal tumor (GIST). Immunohistochemical stainings of GIST (all 200×) showed negative immunohistochemical stainings of CD31 (A) and CK (B), positive stainings of caldeds (C), CD34 (D), DOG-1 (E), EMA (F), vim (G), CD117 (H). CK = cytokeratin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120947&req=5

Figure 2: Pathologic analysis of the gastrointestinal stromal tumor (GIST). Immunohistochemical stainings of GIST (all 200×) showed negative immunohistochemical stainings of CD31 (A) and CK (B), positive stainings of caldeds (C), CD34 (D), DOG-1 (E), EMA (F), vim (G), CD117 (H). CK = cytokeratin.
Mentions: The ultrasound colonoscopy and imaging features are shown in Fig. 1. The tumor resected was proved to be GIST pathologically. The tumor cells diffusely and strongly expressed CD117, CD34, Vim, DOG1, CalDes, and the nidus expressed the protein EMA locally (Fig. 2). It also showed Ki-67 labeling rates of 1% and no desmin (DES), glial fibrillary acidic protein (GFAP), cytokeratin, muscle-specific actin (MSA), smooth muscle actin (SMA), and S100 were expressed in the tissue pathologic analysis. The resection margins were free of tumor cells histologically. No urinary dysfunction and injury were observed postsurgically. No local recurrence or distant metastasis was observed during the 14-month follow-up.

View Article: PubMed Central - PubMed

ABSTRACT

Rationale:: Gastrointestinal stromal tumor (GIST) is the neoplasm of gastrointestinal tract.

Patient concerns:: The patient complained about the retention of urinary.

Diagnoses:: GIST.

Interventions:: radical prostatectomy and the imatinib therapy.

Outcomes:: No recurrence and metastasis have been found during a 14-month follow-up.

Lessons:: comprehensive treatment is necessary for the GIST treatment. Furthermore, we summarize a review of the literature of GIST occurring in the prostate gland treated by different methods and 4 kinds of rare diseases in prostate.

No MeSH data available.


Related in: MedlinePlus