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Characteristics of hearing loss in patients with herpes zoster oticus

View Article: PubMed Central - PubMed

ABSTRACT

Patients with herpes zoster oticus (HZO) may commonly show symptoms associated with 7th and 8th cranial nerve (CN VII and CN VIII) dysfunction. The aim of this study is to investigate the characteristics of hearing loss in patients with HZO and discuss possible mechanisms.

Ninety-five HZO patients who showed at least one of the symptoms of CN VII and CN VIII dysfunction between January 2007 and October 2014 were included in this study. Hearing loss was defined when the mean thresholds of pure tone audiometry (PTA) in speech frequency (0.5 kHz + 1 kHz + 2 kHz/3) or isolated high frequency (4 kHz + 8 kHz/2) were greater than 10 dB in the affected ear compared with the healthy ear, and a total of 72 patients were classified as the hearing loss group.

The difference of mean PTA thresholds between affected and healthy ears was significantly greater in the high frequency range than in low range (20.0 ± 11.5 dB vs. 12.9 ± 15.7 dB, P = 0.0026) in patients with hearing loss (n = 72). The difference between affected and healthy ear was significantly greater in patients with vertigo (n = 34) than those without vertigo (n = 38) in both the high (P = 0.033) and low (P = 0.024) frequency ranges. In contrast, the differences between affected and healthy ears were not significantly different between patients with facial palsy (n = 50) and those without facial palsy (n = 22) in both the high (P = 0.921) and low (P = 0.382) frequency ranges.

In patients with HZO, hearing loss is more severe in the high frequency range than in the low frequency range. Hearing impairment is more severe in patients with vertigo than in those without vertigo in both the high and low frequency ranges, even though the degree of hearing impairment is not significantly different between patients with and without facial palsy. These findings indicate that the mechanisms of viral spread from CN VII to CN VIII may differ between vestibular and audiologic deficits.

No MeSH data available.


Related in: MedlinePlus

Patient distribution according to the symptoms of CN VII and VIII dysfunction. FP = facial palsy; V = vertigo.
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Figure 1: Patient distribution according to the symptoms of CN VII and VIII dysfunction. FP = facial palsy; V = vertigo.

Mentions: Among the patients with hearing loss (n = 72), patients with all 3 symptoms of CN VII and VIII dysfunction (facial palsy, vertigo, and hearing loss) were the most common (39%, 28/72), followed by patients with facial palsy without vertigo (31%, 22/72). Among the patients without hearing loss (n = 23), patients with facial palsy without vertigo were the most common (87%, 20/23) and only 1 patient had vertigo without facial palsy (Fig. 1).


Characteristics of hearing loss in patients with herpes zoster oticus
Patient distribution according to the symptoms of CN VII and VIII dysfunction. FP = facial palsy; V = vertigo.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120946&req=5

Figure 1: Patient distribution according to the symptoms of CN VII and VIII dysfunction. FP = facial palsy; V = vertigo.
Mentions: Among the patients with hearing loss (n = 72), patients with all 3 symptoms of CN VII and VIII dysfunction (facial palsy, vertigo, and hearing loss) were the most common (39%, 28/72), followed by patients with facial palsy without vertigo (31%, 22/72). Among the patients without hearing loss (n = 23), patients with facial palsy without vertigo were the most common (87%, 20/23) and only 1 patient had vertigo without facial palsy (Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

Patients with herpes zoster oticus (HZO) may commonly show symptoms associated with 7th and 8th cranial nerve (CN VII and CN VIII) dysfunction. The aim of this study is to investigate the characteristics of hearing loss in patients with HZO and discuss possible mechanisms.

Ninety-five HZO patients who showed at least one of the symptoms of CN VII and CN VIII dysfunction between January 2007 and October 2014 were included in this study. Hearing loss was defined when the mean thresholds of pure tone audiometry (PTA) in speech frequency (0.5 kHz + 1 kHz + 2 kHz/3) or isolated high frequency (4 kHz + 8 kHz/2) were greater than 10 dB in the affected ear compared with the healthy ear, and a total of 72 patients were classified as the hearing loss group.

The difference of mean PTA thresholds between affected and healthy ears was significantly greater in the high frequency range than in low range (20.0 ± 11.5 dB vs. 12.9 ± 15.7 dB, P = 0.0026) in patients with hearing loss (n = 72). The difference between affected and healthy ear was significantly greater in patients with vertigo (n = 34) than those without vertigo (n = 38) in both the high (P = 0.033) and low (P = 0.024) frequency ranges. In contrast, the differences between affected and healthy ears were not significantly different between patients with facial palsy (n = 50) and those without facial palsy (n = 22) in both the high (P = 0.921) and low (P = 0.382) frequency ranges.

In patients with HZO, hearing loss is more severe in the high frequency range than in the low frequency range. Hearing impairment is more severe in patients with vertigo than in those without vertigo in both the high and low frequency ranges, even though the degree of hearing impairment is not significantly different between patients with and without facial palsy. These findings indicate that the mechanisms of viral spread from CN VII to CN VIII may differ between vestibular and audiologic deficits.

No MeSH data available.


Related in: MedlinePlus