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Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen

View Article: PubMed Central - PubMed

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether occupational stress was associated with NAFLD in a police population.

A total of 6559 male police officers were recruited for this prospective study in April 2007. Among them, 2367 eligible subjects participated in follow-up from 2008 to 2011. NAFLD was diagnosed based on standard criteria. Occupational stress was evaluated by Occupational Stress Inventory-Revised scores.

The incidence of NAFLD was 31.2% in the entire police. After adjusting for traditional risk factors, moderate occupational stress (MOS), high occupational stress (HOS), and high personal strain (HPS) were risk factors (MOS: hazard ratio [HR] = 1.237, 95% confidence interval [CI] = 1.049–1.460; HOS: HR = 1.727, 95% CI = 1.405–2.124; HPS: HR = 3.602, 95% CI = 1.912–6.787); and low occupational stress (LOS) and low personal strain (LPS) were protective factors (LOS: HR = 0.366, 95% CI = 0.173–0.776; LPS: HR = 0.490, 95% CI = 0.262–0.919) for NAFLD in the entire police cohort. HOS and HPS remained robust among traffic police.

HOS and HPS were independent predictors for the development of NAFLD in a Chinese police population. Additional future prospective investigations are warranted to validate our findings.

No MeSH data available.


Flow chart of the study population.
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Figure 1: Flow chart of the study population.

Mentions: All the subjects in our study were recruited in April 2007 at the Medical Center of Police Hospital in Tianjin, China, where medical examinations are provided to both working and retired policemen every year.[9,11] A total of 6559 male police officers (aged 20–60 years) participated in the study; they received free health examinations, and completed the OSI-R questionnaire and interviewer-administered questionnaires. Among them, 4192 participants were excluded based on the following criteria: 408 did not complete the OSI-R and self-designed questionnaires at baseline; 295 had missing ultrasound scanning data; 981 had a history of or concurrent alcohol abuse (more than 30 g/d for males)[12]; 362 were using steatohepatitis medication; 2146 had been diagnosed with NAFLD, chronic hepatitis B or C, autoimmune hepatitis or other liver diseases at the beginning of the study. Ultimately, the other 2367 subjects agreed to be followed up with dynamic observations each year from 2008 to 2011 (see Fig. 1 for a subject flowchart).


Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen
Flow chart of the study population.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120923&req=5

Figure 1: Flow chart of the study population.
Mentions: All the subjects in our study were recruited in April 2007 at the Medical Center of Police Hospital in Tianjin, China, where medical examinations are provided to both working and retired policemen every year.[9,11] A total of 6559 male police officers (aged 20–60 years) participated in the study; they received free health examinations, and completed the OSI-R questionnaire and interviewer-administered questionnaires. Among them, 4192 participants were excluded based on the following criteria: 408 did not complete the OSI-R and self-designed questionnaires at baseline; 295 had missing ultrasound scanning data; 981 had a history of or concurrent alcohol abuse (more than 30 g/d for males)[12]; 362 were using steatohepatitis medication; 2146 had been diagnosed with NAFLD, chronic hepatitis B or C, autoimmune hepatitis or other liver diseases at the beginning of the study. Ultimately, the other 2367 subjects agreed to be followed up with dynamic observations each year from 2008 to 2011 (see Fig. 1 for a subject flowchart).

View Article: PubMed Central - PubMed

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether occupational stress was associated with NAFLD in a police population.

A total of 6559 male police officers were recruited for this prospective study in April 2007. Among them, 2367 eligible subjects participated in follow-up from 2008 to 2011. NAFLD was diagnosed based on standard criteria. Occupational stress was evaluated by Occupational Stress Inventory-Revised scores.

The incidence of NAFLD was 31.2% in the entire police. After adjusting for traditional risk factors, moderate occupational stress (MOS), high occupational stress (HOS), and high personal strain (HPS) were risk factors (MOS: hazard ratio [HR] = 1.237, 95% confidence interval [CI] = 1.049–1.460; HOS: HR = 1.727, 95% CI = 1.405–2.124; HPS: HR = 3.602, 95% CI = 1.912–6.787); and low occupational stress (LOS) and low personal strain (LPS) were protective factors (LOS: HR = 0.366, 95% CI = 0.173–0.776; LPS: HR = 0.490, 95% CI = 0.262–0.919) for NAFLD in the entire police cohort. HOS and HPS remained robust among traffic police.

HOS and HPS were independent predictors for the development of NAFLD in a Chinese police population. Additional future prospective investigations are warranted to validate our findings.

No MeSH data available.