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Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention

View Article: PubMed Central - PubMed

ABSTRACT

In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.

We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year.

The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels. Moreover, these patients showed significantly higher post-procedural peak values of creatine kinase-MB and troponin I in comparison to patients with lower HMGB1 levels. Event-free survival was significantly associated with HMGB1 levels, with worst event-free survival in patients with elevated HMGB1 levels.

Elevated preoperative HMGB1 was a predictor of myocardial injury after percutaneous coronary intervention, and was associated with the worst clinical outcomes during 1-year follow up.

No MeSH data available.


Post-procedural peak values of creatine kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI).
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Figure 2: Post-procedural peak values of creatine kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI).

Mentions: The occurrence of PMI was significantly increased across the tertiles of HMGB1. Similar pre-procedural levels of markers CK-MB and cTnI were determined amongst the three tertiles. CK-MB elevation was observed in 28 (28.0%) patients of tertile 3, 16 (15.8%) patients of tertile 2, and 10 (9.9%) patients of tertile 1 (P = 0.037 and 0.001, respectively). Also, elevated cTnI levels were observed in 30 (30%) patients in tertile 3, 18 (17.8%) in tertile 2, and 9 (8.9%) in tertile 1 (P = 0.043 and P < 0.001, respectively) (Fig. 1). Post-procedural peak values of CK-MB were significantly higher for patients in tertile 3 (4.2 [1.8–11.0] ng/mL) than patients in tertile 2 (3.0 [1.5–8.5] ng/mL, P = 0.042) and tertile 1 (1.5 [1.0–3.1] ng/mL, P = 0.001). Post-procedural cTnI levels were significantly higher in tertile 3 patients (0.030 [0.010–0.148] ng/mL) than those in tertile 2 (0.020 [0.000–0.085] ng/mL, P = 0.030) and tertile 1 (0.020 [0.000–0.040] ng/mL, P < 0.001) (Fig. 2).


Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention
Post-procedural peak values of creatine kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120896&req=5

Figure 2: Post-procedural peak values of creatine kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI).
Mentions: The occurrence of PMI was significantly increased across the tertiles of HMGB1. Similar pre-procedural levels of markers CK-MB and cTnI were determined amongst the three tertiles. CK-MB elevation was observed in 28 (28.0%) patients of tertile 3, 16 (15.8%) patients of tertile 2, and 10 (9.9%) patients of tertile 1 (P = 0.037 and 0.001, respectively). Also, elevated cTnI levels were observed in 30 (30%) patients in tertile 3, 18 (17.8%) in tertile 2, and 9 (8.9%) in tertile 1 (P = 0.043 and P < 0.001, respectively) (Fig. 1). Post-procedural peak values of CK-MB were significantly higher for patients in tertile 3 (4.2 [1.8–11.0] ng/mL) than patients in tertile 2 (3.0 [1.5–8.5] ng/mL, P = 0.042) and tertile 1 (1.5 [1.0–3.1] ng/mL, P = 0.001). Post-procedural cTnI levels were significantly higher in tertile 3 patients (0.030 [0.010–0.148] ng/mL) than those in tertile 2 (0.020 [0.000–0.085] ng/mL, P = 0.030) and tertile 1 (0.020 [0.000–0.040] ng/mL, P < 0.001) (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.

We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year.

The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels. Moreover, these patients showed significantly higher post-procedural peak values of creatine kinase-MB and troponin I in comparison to patients with lower HMGB1 levels. Event-free survival was significantly associated with HMGB1 levels, with worst event-free survival in patients with elevated HMGB1 levels.

Elevated preoperative HMGB1 was a predictor of myocardial injury after percutaneous coronary intervention, and was associated with the worst clinical outcomes during 1-year follow up.

No MeSH data available.