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Enhanced identification and functional protective role of carbon nanoparticles on parathyroid in thyroid cancer surgery

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to determine the effects of nanocarbon particles in combination with meticulous capsular dissection on enhancing the identification and protecting the function of parathyroid glands in thyroid cancer surgery.

The data of 97 patients with papillary thyroid tumors diagnosed and treated at the Second Affiliated Hospital, Harbin Medical University between January 2014 and February 2015 were reviewed. Data regarding the sex, age, calcium and parathyroid hormone (PTH) levels, tumor size, multifocality, T stage, and extrathyroid invasion were collected. The incidence of surgeries in which the parathyroid glands were cut mistakenly, the concentration of serum calcium and parathyroid hormone before surgery (baseline) and after surgery on days 1, 3, and 7, and 1 and 6 months in the patients of the two groups (the nanocarbon and control groups) were analyzed.

Fifty-two patients underwent meticulous capsular dissection combined with nanocarbon treatment (nanocarbon group), and 45 underwent meticulous capsular dissection alone (control group). The nanocarbon group showed a significantly higher total and average number of revealed parathyroid glands (average number is the mean for different individuals have different number) and a lower incidence of the parathyroid glands being mistakenly cut, in addition to a lower level of hypoparathyroidism than control group following surgery (P < 0.05). Serum calcium and PTH levels were significantly lower in patients from both groups after surgery on days 1, 3, and 7 and after 1 month, compared with the preoperative levels (P < 0.05). Compared with the control group, the serum calcium and PTH levels were significantly higher in the nanocarbon group after surgery on days 1, 3, 7, than in the control group.

Treatment with nanocarbon in combination with meticulous capsular dissection can significantly facilitate the identification of the parathyroid in thyroid cancer surgery, reduce the risk of mistakenly cutting the parathyroid, and reduce the incidence of postoperative hypoparathyroidism.

No MeSH data available.


Serum calcium and PTH levels of patients in the 2 groups before and after surgery. (A) Calcium and (B) PTH levels; #P < 0.05 in comparison with preoperative levels in both groups; ∗P < 0.05, in comparison with the control group.
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Figure 2: Serum calcium and PTH levels of patients in the 2 groups before and after surgery. (A) Calcium and (B) PTH levels; #P < 0.05 in comparison with preoperative levels in both groups; ∗P < 0.05, in comparison with the control group.

Mentions: As shown in Fig. 2, serum calcium and PTH levels were significantly lower in both groups 1, 3, and 7 days after surgery compared with preoperative levels (P < 0.05), and the PTH levels were still significantly lower at 1 month after surgery than before (P < 0.05). Compared with the control group, the postoperative PTH levels decreased less in the nanocarbon group, and the serum calcium and PTH levels were significantly higher in nanocarbon group 1, 3 and 7 days after surgery compared with the control group (P < 0.05). There was no significant difference in the rate of postoperative hypocalcemia between the 2 groups, and the rates were 13.4% and 22.2%, respectively, for the nanocarbon and control groups. After 6 months, the serum calcium levels had returned to normal. Changes in the blood calcium levels in patients were affected by the changes of postoperative PTH. Although calcium was administered after surgery in patients, the alteration calcium concentration was still affected by the PTH levels. Furthermore, with the supplementation of calcium through the veins, postoperative serum calcium concentration levels in the nanocarbon group were returned to approximately normal levels more rapidly compared with the control group.


Enhanced identification and functional protective role of carbon nanoparticles on parathyroid in thyroid cancer surgery
Serum calcium and PTH levels of patients in the 2 groups before and after surgery. (A) Calcium and (B) PTH levels; #P < 0.05 in comparison with preoperative levels in both groups; ∗P < 0.05, in comparison with the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120895&req=5

Figure 2: Serum calcium and PTH levels of patients in the 2 groups before and after surgery. (A) Calcium and (B) PTH levels; #P < 0.05 in comparison with preoperative levels in both groups; ∗P < 0.05, in comparison with the control group.
Mentions: As shown in Fig. 2, serum calcium and PTH levels were significantly lower in both groups 1, 3, and 7 days after surgery compared with preoperative levels (P < 0.05), and the PTH levels were still significantly lower at 1 month after surgery than before (P < 0.05). Compared with the control group, the postoperative PTH levels decreased less in the nanocarbon group, and the serum calcium and PTH levels were significantly higher in nanocarbon group 1, 3 and 7 days after surgery compared with the control group (P < 0.05). There was no significant difference in the rate of postoperative hypocalcemia between the 2 groups, and the rates were 13.4% and 22.2%, respectively, for the nanocarbon and control groups. After 6 months, the serum calcium levels had returned to normal. Changes in the blood calcium levels in patients were affected by the changes of postoperative PTH. Although calcium was administered after surgery in patients, the alteration calcium concentration was still affected by the PTH levels. Furthermore, with the supplementation of calcium through the veins, postoperative serum calcium concentration levels in the nanocarbon group were returned to approximately normal levels more rapidly compared with the control group.

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to determine the effects of nanocarbon particles in combination with meticulous capsular dissection on enhancing the identification and protecting the function of parathyroid glands in thyroid cancer surgery.

The data of 97 patients with papillary thyroid tumors diagnosed and treated at the Second Affiliated Hospital, Harbin Medical University between January 2014 and February 2015 were reviewed. Data regarding the sex, age, calcium and parathyroid hormone (PTH) levels, tumor size, multifocality, T stage, and extrathyroid invasion were collected. The incidence of surgeries in which the parathyroid glands were cut mistakenly, the concentration of serum calcium and parathyroid hormone before surgery (baseline) and after surgery on days 1, 3, and 7, and 1 and 6 months in the patients of the two groups (the nanocarbon and control groups) were analyzed.

Fifty-two patients underwent meticulous capsular dissection combined with nanocarbon treatment (nanocarbon group), and 45 underwent meticulous capsular dissection alone (control group). The nanocarbon group showed a significantly higher total and average number of revealed parathyroid glands (average number is the mean for different individuals have different number) and a lower incidence of the parathyroid glands being mistakenly cut, in addition to a lower level of hypoparathyroidism than control group following surgery (P&#8202;&lt;&#8202;0.05). Serum calcium and PTH levels were significantly lower in patients from both groups after surgery on days 1, 3, and 7 and after 1 month, compared with the preoperative levels (P&#8202;&lt;&#8202;0.05). Compared with the control group, the serum calcium and PTH levels were significantly higher in the nanocarbon group after surgery on days 1, 3, 7, than in the control group.

Treatment with nanocarbon in combination with meticulous capsular dissection can significantly facilitate the identification of the parathyroid in thyroid cancer surgery, reduce the risk of mistakenly cutting the parathyroid, and reduce the incidence of postoperative hypoparathyroidism.

No MeSH data available.