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Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet

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ABSTRACT

The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.

No MeSH data available.


Related in: MedlinePlus

Time to peak, expressed in seconds, under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p< 0.01 vs T0 NW group, * p< 0.01 vs T0 NG group, ** p<0.01 vs T0.
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f5-tm-15-01: Time to peak, expressed in seconds, under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p< 0.01 vs T0 NW group, * p< 0.01 vs T0 NG group, ** p<0.01 vs T0.

Mentions: Hyperemic response was significantly different in the experimental groups under baseline conditions (time T0), resulting impaired in hyperglycemic group. In particular, all groups showed an increase in microvascular blood flow above the baseline following 2 min brachial artery occlusion. However, the peak value was lower in hyperglycemic than in normoglycemic and normal weight subjects (30.8 ± 2.9 vs 60.3 ± 2.5 and 72.3 ± 1.5 PU, respectively; p<0.01 vs NG and NW groups; Figure 4) as well as the percent increase from baseline (345.3 ± 28.0 vs 552.0 ± 27.4 and 670.0 ± 15.6 %, respectively; p<0.01 vs NG and NW groups) and the duration of hyperemia (30.1 ± 1.2 vs 41.9 ± 2.2 and 43.2 ± 1.3 seconds, p<0.01 vs NG and NW groups). Consequently, time to peak was higher in hyperglycemic than in normoglycemic and normal weight subjects (9.2 ± 0.5 vs 7.1 ± 0.3 and 5.9 ± 0.2 seconds, respectively; p<0.01 vs NG and NW groups; Figure 5).


Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet
Time to peak, expressed in seconds, under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p< 0.01 vs T0 NW group, * p< 0.01 vs T0 NG group, ** p<0.01 vs T0.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120744&req=5

f5-tm-15-01: Time to peak, expressed in seconds, under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p< 0.01 vs T0 NW group, * p< 0.01 vs T0 NG group, ** p<0.01 vs T0.
Mentions: Hyperemic response was significantly different in the experimental groups under baseline conditions (time T0), resulting impaired in hyperglycemic group. In particular, all groups showed an increase in microvascular blood flow above the baseline following 2 min brachial artery occlusion. However, the peak value was lower in hyperglycemic than in normoglycemic and normal weight subjects (30.8 ± 2.9 vs 60.3 ± 2.5 and 72.3 ± 1.5 PU, respectively; p<0.01 vs NG and NW groups; Figure 4) as well as the percent increase from baseline (345.3 ± 28.0 vs 552.0 ± 27.4 and 670.0 ± 15.6 %, respectively; p<0.01 vs NG and NW groups) and the duration of hyperemia (30.1 ± 1.2 vs 41.9 ± 2.2 and 43.2 ± 1.3 seconds, p<0.01 vs NG and NW groups). Consequently, time to peak was higher in hyperglycemic than in normoglycemic and normal weight subjects (9.2 ± 0.5 vs 7.1 ± 0.3 and 5.9 ± 0.2 seconds, respectively; p<0.01 vs NG and NW groups; Figure 5).

View Article: PubMed Central - PubMed

ABSTRACT

The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.

No MeSH data available.


Related in: MedlinePlus