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Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet

View Article: PubMed Central - PubMed

ABSTRACT

The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.

No MeSH data available.


Related in: MedlinePlus

Skin microvascular blood flow, expressed as Perfusion Units (PU), under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p<0.01 vs T0 NW group, * p<0.01 vs T0 NG group ; ** p< 0.01 vs T0
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f1-tm-15-01: Skin microvascular blood flow, expressed as Perfusion Units (PU), under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p<0.01 vs T0 NW group, * p<0.01 vs T0 NG group ; ** p< 0.01 vs T0

Mentions: LDPM measurements revealed significant differences between normoglycemic and hyperglycemic obese patients under baseline conditions (time T0) compared to normal weight subjects. Hyperglycemic subjects showed lower mean value of SBF than normoglycemic ones (9.9 ± 0.5 vs 11.8 ± 0.6 PU, p<0.01 vs NG group; Figure 1), while normal weight subjects had baseline perfusion of 11.3 ± 0.5 PU (p<0.01 vs HG group). Moreover, spectral analysis indicates that total PSD of SBF recording was lower in the hyperglycemic than in normoglycemic obese and normal weight subjects (113.2 ± 10.1 vs 176.5 ± 11.4 and 170.4 ± 12.3 PU2/Hz, p<0.01 vs NG and NW group).


Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet
Skin microvascular blood flow, expressed as Perfusion Units (PU), under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p<0.01 vs T0 NW group, * p<0.01 vs T0 NG group ; ** p< 0.01 vs T0
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120744&req=5

f1-tm-15-01: Skin microvascular blood flow, expressed as Perfusion Units (PU), under baseline conditions (T0) and at six months (T2) of diet administration in normal weight (NW), normoglycemic (NG) and hyperglycemic patients (HG). ∘ p<0.01 vs T0 NW group, * p<0.01 vs T0 NG group ; ** p< 0.01 vs T0
Mentions: LDPM measurements revealed significant differences between normoglycemic and hyperglycemic obese patients under baseline conditions (time T0) compared to normal weight subjects. Hyperglycemic subjects showed lower mean value of SBF than normoglycemic ones (9.9 ± 0.5 vs 11.8 ± 0.6 PU, p<0.01 vs NG group; Figure 1), while normal weight subjects had baseline perfusion of 11.3 ± 0.5 PU (p<0.01 vs HG group). Moreover, spectral analysis indicates that total PSD of SBF recording was lower in the hyperglycemic than in normoglycemic obese and normal weight subjects (113.2 ± 10.1 vs 176.5 ± 11.4 and 170.4 ± 12.3 PU2/Hz, p<0.01 vs NG and NW group).

View Article: PubMed Central - PubMed

ABSTRACT

The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.

No MeSH data available.


Related in: MedlinePlus