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Evaluation of polyphenylene ether ether sulfone/nanohydroxyapatite nanofiber composite as a biomaterial for hard tissue replacement

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ABSTRACT

The present work is aimed at investigating the mechanical and in vitro biological properties of polyphenylene ether ether sulfone (PPEES)/nanohydroxyapatite (nHA) composite fibers. Electrospinning was used to prepare nanofiber composite mats of PPEES/nHA with different weight percentages of the inorganic filler, nHA. The fabricated composites were characterized using Fourier transform infrared spectroscopy (FTIR)-attenuated total reflectance spectroscopy (ATR) and scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDX) techniques. The mechanical properties of the composite were studied with a tensile tester. The FTIR-ATR spectrum depicted the functional group as well as the interaction between the PPEES and nHA composite materials; in addition, the elemental groups were identified with EDX analysis. The morphology of the nanofiber composite was studied by SEM. Tensile strength analysis of the PPEES/nHA composite revealed the elastic nature of the nanofiber composite reinforced with nHA and suggested significant mechanical strength of the composite. The biomineralization studies performed using simulated body fluid with increased incubation time showed enhanced mineralization, which showed that the composites possessed high bioactivity property. Cell viability of the nanofiber composite, studied with osteoblast (MG-63) cells, was observed to be higher in the composites containing higher concentrations of nHA.

Electronic supplementary material: The online version of this article (doi:10.1186/2194-0517-2-2) contains supplementary material, which is available to authorized users.

No MeSH data available.


FTIR-ATR spectra of PPEES nanofiber and its composite: (curve a) PPEES nanofiber, (curve b) PPEES 1, (curve c) PPEES 2, and (curve d) PPEES 3.
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Fig1: FTIR-ATR spectra of PPEES nanofiber and its composite: (curve a) PPEES nanofiber, (curve b) PPEES 1, (curve c) PPEES 2, and (curve d) PPEES 3.

Mentions: The FTIR-ATR spectra of nHA reinforced PPEES nanofiber composites and bare nanofiber mat are shown in Figure 1. From the spectra, the intense broad band (Figure 1b–d) observed at 3500 cm−1 was assigned to the OH stretching vibration which was mainly observed when steric hindrance prevents polymeric association and also confirmed the interaction of nHA with PPEES. The intensity of the peak at 3068 cm−1 (Figure 1a) was due to the fact that the adsorption peak of C-H stretching vibration was overlapped by the O-H stretching vibration peaks of nHA. The C=C aromatic ring vibrations were attributed to the peaks occurring at 1578 cm−1; intensity of the peak decreased with the addition of nHA due to the interaction of HA with the polymer backbone. The peak at 1375 cm−1 corresponds to the ester linkage of the polymer chain. The strong absorption peaks just above 1250 and 1100 cm−1 correspond to the diaryl sulfone (Ar-SO2-Ar) and diaryl ether (Ar-O-Ar) groups, respectively (Dahe et al. 2011). It was observed that the phosphate vibrations were merged with the S=O vibrations just above 1000 cm−1. The aromatic ring CH bending vibration occurred just above 800 cm−1.Figure 1


Evaluation of polyphenylene ether ether sulfone/nanohydroxyapatite nanofiber composite as a biomaterial for hard tissue replacement
FTIR-ATR spectra of PPEES nanofiber and its composite: (curve a) PPEES nanofiber, (curve b) PPEES 1, (curve c) PPEES 2, and (curve d) PPEES 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120667&req=5

Fig1: FTIR-ATR spectra of PPEES nanofiber and its composite: (curve a) PPEES nanofiber, (curve b) PPEES 1, (curve c) PPEES 2, and (curve d) PPEES 3.
Mentions: The FTIR-ATR spectra of nHA reinforced PPEES nanofiber composites and bare nanofiber mat are shown in Figure 1. From the spectra, the intense broad band (Figure 1b–d) observed at 3500 cm−1 was assigned to the OH stretching vibration which was mainly observed when steric hindrance prevents polymeric association and also confirmed the interaction of nHA with PPEES. The intensity of the peak at 3068 cm−1 (Figure 1a) was due to the fact that the adsorption peak of C-H stretching vibration was overlapped by the O-H stretching vibration peaks of nHA. The C=C aromatic ring vibrations were attributed to the peaks occurring at 1578 cm−1; intensity of the peak decreased with the addition of nHA due to the interaction of HA with the polymer backbone. The peak at 1375 cm−1 corresponds to the ester linkage of the polymer chain. The strong absorption peaks just above 1250 and 1100 cm−1 correspond to the diaryl sulfone (Ar-SO2-Ar) and diaryl ether (Ar-O-Ar) groups, respectively (Dahe et al. 2011). It was observed that the phosphate vibrations were merged with the S=O vibrations just above 1000 cm−1. The aromatic ring CH bending vibration occurred just above 800 cm−1.Figure 1

View Article: PubMed Central

ABSTRACT

The present work is aimed at investigating the mechanical and in vitro biological properties of polyphenylene ether ether sulfone (PPEES)/nanohydroxyapatite (nHA) composite fibers. Electrospinning was used to prepare nanofiber composite mats of PPEES/nHA with different weight percentages of the inorganic filler, nHA. The fabricated composites were characterized using Fourier transform infrared spectroscopy (FTIR)-attenuated total reflectance spectroscopy (ATR) and scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDX) techniques. The mechanical properties of the composite were studied with a tensile tester. The FTIR-ATR spectrum depicted the functional group as well as the interaction between the PPEES and nHA composite materials; in addition, the elemental groups were identified with EDX analysis. The morphology of the nanofiber composite was studied by SEM. Tensile strength analysis of the PPEES/nHA composite revealed the elastic nature of the nanofiber composite reinforced with nHA and suggested significant mechanical strength of the composite. The biomineralization studies performed using simulated body fluid with increased incubation time showed enhanced mineralization, which showed that the composites possessed high bioactivity property. Cell viability of the nanofiber composite, studied with osteoblast (MG-63) cells, was observed to be higher in the composites containing higher concentrations of nHA.

Electronic supplementary material: The online version of this article (doi:10.1186/2194-0517-2-2) contains supplementary material, which is available to authorized users.

No MeSH data available.