Limits...
Promoter Polymorphism ( − 174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: Ischemic stroke and myocardial infarction are fatal diseases and are among the top 10 causes of death in Korea, including arterial thromboembolic events. Many previous studies have described the function of interleukin-6 (IL-6) in arterial thromboembolic events and the association between promoter single-nucleotide polymorphism (SNP) (rs1800795; −174, G/C) of the IL-6 gene. However, these results were controversial. Therefore, we performed a meta-analysis to more precisely assess the association between the SNP of the IL-6 gene and susceptibility to arterial thromboembolic events.

Material/methods: We used PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases. Comprehensive Meta-analysis software (Corporation, NJ) was used to evaluate the relationship between rs1800795 SNP of IL-6 gene and risk of arterial thromboembolic events. Odds ratio (OR), 95% confidence interval (CI), and P value were also calculated. The 13 eligible studies were analyzed in the meta-analysis.

Results: The present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model).

Conclusions: We found that rs1800795 SNP of IL-6 gene was not related to arterial thromboembolic events. However, further study will be needed to confirm these results.

No MeSH data available.


Related in: MedlinePlus

Interleukin-6 polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC5120647&req=5

f1-medscimonit-22-4345: Interleukin-6 polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events.

Mentions: Table 2 and Figure 1 shows overall results between IL-6 gene polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events. We analyzed whether risk of the C allele and combined genotype of the SNP were related with susceptibility of arterial thromboembolic events. The results of the Q test were P value or I2statistic in analysis of C allele vs. G allele, CC genotype vs. CG genotype+GG genotype, and CC genotype+CG genotype vs. GG genotype were <0.05 and >50%, the random-effects Mantel-Haenszel method was used (Table 2). In analysis, the pooled ORs and P value in allele model and combined genotype models did not show any significant association with susceptibility of arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC genotype vs. CG genotype+GG genotype, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC genotype+CG genotype vs. GG genotype, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively) (Table 1, Figure 1).


Promoter Polymorphism ( − 174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis
Interleukin-6 polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5120647&req=5

f1-medscimonit-22-4345: Interleukin-6 polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events.
Mentions: Table 2 and Figure 1 shows overall results between IL-6 gene polymorphism (−174, G/C) and susceptibility to arterial thromboembolic events. We analyzed whether risk of the C allele and combined genotype of the SNP were related with susceptibility of arterial thromboembolic events. The results of the Q test were P value or I2statistic in analysis of C allele vs. G allele, CC genotype vs. CG genotype+GG genotype, and CC genotype+CG genotype vs. GG genotype were <0.05 and >50%, the random-effects Mantel-Haenszel method was used (Table 2). In analysis, the pooled ORs and P value in allele model and combined genotype models did not show any significant association with susceptibility of arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC genotype vs. CG genotype+GG genotype, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC genotype+CG genotype vs. GG genotype, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively) (Table 1, Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Ischemic stroke and myocardial infarction are fatal diseases and are among the top 10 causes of death in Korea, including arterial thromboembolic events. Many previous studies have described the function of interleukin-6 (IL-6) in arterial thromboembolic events and the association between promoter single-nucleotide polymorphism (SNP) (rs1800795; &minus;174, G/C) of the IL-6 gene. However, these results were controversial. Therefore, we performed a meta-analysis to more precisely assess the association between the SNP of the IL-6 gene and susceptibility to arterial thromboembolic events.

Material/methods: We used PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases. Comprehensive Meta-analysis software (Corporation, NJ) was used to evaluate the relationship between rs1800795 SNP of IL-6 gene and risk of arterial thromboembolic events. Odds ratio (OR), 95% confidence interval (CI), and P value were also calculated. The 13 eligible studies were analyzed in the meta-analysis.

Results: The present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91&ndash;1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91&ndash;1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78&ndash;1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P&gt;0.05 in each model).

Conclusions: We found that rs1800795 SNP of IL-6 gene was not related to arterial thromboembolic events. However, further study will be needed to confirm these results.

No MeSH data available.


Related in: MedlinePlus