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Effect of Posterior Cruciate Ligament Rupture on Biomechanical and Histological Features of Lateral Femoral Condyle

View Article: PubMed Central - PubMed

ABSTRACT

Background: The aim of this study was to investigate bone mineral density (BMD) and the biomechanical and histological effects of posterior cruciate ligament (PCL) rupture on the lateral femoral condyle.

Material/methods: Strain on different parts of the lateral femoral condyle from specimens of normal adult knee joints, including 12 intact PCLs, 6 ruptures of the anterolateral bundle, 6 ruptures of the postmedial bundle, and 12 complete ruptures, was tested when loaded with different loads on the knee at various flexion angles. Lateral femoral condyles were also collected randomly from both the experimental side in which the PCLs were transected and the control side from 4 sets of 12 matched-mode pairs of rabbits at 4, 8, 16, and 24 weeks after surgery, and their BMD and morphological and histological changes were observed.

Results: Partial and complete rupture of the PCL may cause an abnormal load on all parts of the lateral femoral condyle with any axial loading at all positions. Noticeable time-dependent degenerative histological changes of the lateral femoral condyle were observed in the rabbit model of PCL rupture. All of the PCL rupture groups had a higher expression of matrix metalloproteinase-7 (MMP-7) and collagen type II than the control group at all time points (P<0.05), but no significant difference in BMD (P>0.05).

Conclusions: Rupture of the PCL may trigger a coordinated response of lateral femoral condyle degeneration in a time-dependent manner, to which the high level of expression of MMP-7 and collagen type II could contribute.

No MeSH data available.


Related in: MedlinePlus

The installment of strain gauges at anterior, middle, and posterior part of the lateral femoral condyle.
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f1-medscimonit-22-4369: The installment of strain gauges at anterior, middle, and posterior part of the lateral femoral condyle.

Mentions: A lateral parapatellar incision and a lateral femoral condyle posterolateral incision were made to expose the anterior, middle, and posterior parts of the lateral femoral condyle. Three strain gauges were installed on these parts (Figure 1), and the joint capsule was closed with a suture. A static strain-measuring device was used to measure and record the strain at these sites under 200 N, 400 N, 600 N, and 800 N loads at 0°, 30°, 60°, and 90° of flexion. The specimens were then randomly divided into the ALB rupture group (n=6) in which the ALB was transected, and the PMB rupture group (n=6) in which the PMB was transected. The test procedure was repeated in these 2 groups. Finally, the PCL of all 12 specimens was completely transected to create the PCL rupture group, and the same test procedure was repeated.


Effect of Posterior Cruciate Ligament Rupture on Biomechanical and Histological Features of Lateral Femoral Condyle
The installment of strain gauges at anterior, middle, and posterior part of the lateral femoral condyle.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5120644&req=5

f1-medscimonit-22-4369: The installment of strain gauges at anterior, middle, and posterior part of the lateral femoral condyle.
Mentions: A lateral parapatellar incision and a lateral femoral condyle posterolateral incision were made to expose the anterior, middle, and posterior parts of the lateral femoral condyle. Three strain gauges were installed on these parts (Figure 1), and the joint capsule was closed with a suture. A static strain-measuring device was used to measure and record the strain at these sites under 200 N, 400 N, 600 N, and 800 N loads at 0°, 30°, 60°, and 90° of flexion. The specimens were then randomly divided into the ALB rupture group (n=6) in which the ALB was transected, and the PMB rupture group (n=6) in which the PMB was transected. The test procedure was repeated in these 2 groups. Finally, the PCL of all 12 specimens was completely transected to create the PCL rupture group, and the same test procedure was repeated.

View Article: PubMed Central - PubMed

ABSTRACT

Background: The aim of this study was to investigate bone mineral density (BMD) and the biomechanical and histological effects of posterior cruciate ligament (PCL) rupture on the lateral femoral condyle.

Material/methods: Strain on different parts of the lateral femoral condyle from specimens of normal adult knee joints, including 12 intact PCLs, 6 ruptures of the anterolateral bundle, 6 ruptures of the postmedial bundle, and 12 complete ruptures, was tested when loaded with different loads on the knee at various flexion angles. Lateral femoral condyles were also collected randomly from both the experimental side in which the PCLs were transected and the control side from 4 sets of 12 matched-mode pairs of rabbits at 4, 8, 16, and 24 weeks after surgery, and their BMD and morphological and histological changes were observed.

Results: Partial and complete rupture of the PCL may cause an abnormal load on all parts of the lateral femoral condyle with any axial loading at all positions. Noticeable time-dependent degenerative histological changes of the lateral femoral condyle were observed in the rabbit model of PCL rupture. All of the PCL rupture groups had a higher expression of matrix metalloproteinase-7 (MMP-7) and collagen type II than the control group at all time points (P<0.05), but no significant difference in BMD (P>0.05).

Conclusions: Rupture of the PCL may trigger a coordinated response of lateral femoral condyle degeneration in a time-dependent manner, to which the high level of expression of MMP-7 and collagen type II could contribute.

No MeSH data available.


Related in: MedlinePlus