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Expression of IL-1 α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer

View Article: PubMed Central - PubMed

ABSTRACT

Background: IL-1α and IL-6 are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of IL-1α and IL-6 in cervical cancer and their significance in clinical prognosis.

Material/methods: The expression of IL-1α and IL-6 in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and adjacent non-tumor tissues was examined by immunohistochemistry. The results were semi-quantitatively scored and analyzed by chi-square test. Patient overall survival (OS) data was collected by follow-up and analyzed by Kaplan-Meier analysis.

Results: The expression level of both IL-1α and IL-6 in cervical cancer tissue was higher than in adjacent non-tumor tissues (p<0.05). IL-1α expression was shown to be correlated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation (p<0.05). IL-6 expression was shown to be correlated with tumor size, FIGO histology grade, and tumor differentiation (p<0.05). Patients with positive expression of IL-1α or IL-6 tended to have much shorter survival times than patients with negative expression. In addition, a multivariate Cox regression analysis demonstrated that IL-1α expression and lymph node metastasis were independent predictors of OS in cervical cancer patients.

Conclusions: The expression of IL-1α was significantly associated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation. The expression of IL-6 was significantly associated with tumor size, FIGO histology grade, and tumor differentiation. Positive IL-1α and IL-6 expression was significantly correlated with poor prognosis. They may be considered valuable biomarkers for prognosis and potential therapeutic targets for cervical cancer.

No MeSH data available.


Kaplan-Meier survival curves stratified by IL-6.
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f4-medscimonit-22-4475: Kaplan-Meier survival curves stratified by IL-6.

Mentions: In order to further evaluate the relationship between IL-1α and IL-6 expression and prognosis of cervical cancer, we performed log-rank survival analysis according to IL-1α and IL-6 expression level and patient survival data. The survival analysis demonstrated that the cervical cancer survival rate of patients with negative IL-1α or IL-6 expression was significantly better than that of patients with positive expression (p<0.05, Figures 3, 4). Furthermore, a multivariate Cox regression analysis demonstrated that IL-1α expression and lymph node metastasis were independent predictors of overall survival in cervical cancer patients.


Expression of IL-1 α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer
Kaplan-Meier survival curves stratified by IL-6.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5120643&req=5

f4-medscimonit-22-4475: Kaplan-Meier survival curves stratified by IL-6.
Mentions: In order to further evaluate the relationship between IL-1α and IL-6 expression and prognosis of cervical cancer, we performed log-rank survival analysis according to IL-1α and IL-6 expression level and patient survival data. The survival analysis demonstrated that the cervical cancer survival rate of patients with negative IL-1α or IL-6 expression was significantly better than that of patients with positive expression (p<0.05, Figures 3, 4). Furthermore, a multivariate Cox regression analysis demonstrated that IL-1α expression and lymph node metastasis were independent predictors of overall survival in cervical cancer patients.

View Article: PubMed Central - PubMed

ABSTRACT

Background: IL-1&alpha; and IL-6 are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of IL-1&alpha; and IL-6 in cervical cancer and their significance in clinical prognosis.

Material/methods: The expression of IL-1&alpha; and IL-6 in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and adjacent non-tumor tissues was examined by immunohistochemistry. The results were semi-quantitatively scored and analyzed by chi-square test. Patient overall survival (OS) data was collected by follow-up and analyzed by Kaplan-Meier analysis.

Results: The expression level of both IL-1&alpha; and IL-6 in cervical cancer tissue was higher than in adjacent non-tumor tissues (p&lt;0.05). IL-1&alpha; expression was shown to be correlated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation (p&lt;0.05). IL-6 expression was shown to be correlated with tumor size, FIGO histology grade, and tumor differentiation (p&lt;0.05). Patients with positive expression of IL-1&alpha; or IL-6 tended to have much shorter survival times than patients with negative expression. In addition, a multivariate Cox regression analysis demonstrated that IL-1&alpha; expression and lymph node metastasis were independent predictors of OS in cervical cancer patients.

Conclusions: The expression of IL-1&alpha; was significantly associated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation. The expression of IL-6 was significantly associated with tumor size, FIGO histology grade, and tumor differentiation. Positive IL-1&alpha; and IL-6 expression was significantly correlated with poor prognosis. They may be considered valuable biomarkers for prognosis and potential therapeutic targets for cervical cancer.

No MeSH data available.