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Introducing MARCo: Histoserological Findings of a Multi-Organic Paraneoplastic Syndrome in Cutaneous Melanoma Patients

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ABSTRACT

Introduction: Cutaneous melanoma (CM) is an aggressive skin cancer entity, causing most skin cancer-related deaths. Autoimmune disorders have been described as potential paraneoplastic complications. The purpose of this study was to elucidate the possibility of a combinatory paraneoplastic affection of the retina and cochlea in patients with CM.

Methods: Sera samples from CM patients were used for indirect immunofluorescence on histological retinal and cochlear sections. Furthermore, the serum specimen of a patient with symptomatic affection of both organs was analyzed by multiplex ELISA (enzyme-linked immunosorbent assay) for various cytokines including CD163 (cluster of differentiation 163).

Results: Eleven patients were diagnosed with CM. Autoantibodies against structures of the inner ear were confirmed in all patients who were tested positive for antiretinal antibodies as well. CD163 was significantly elevated in the double-symptomatic patient, who developed metastatic disease.

Conclusion: Paraneoplastic disease of CM can affect more than one organ and this affect may be correlated with the individual prognosis. Therefore, a thorough anamnesis is needed to avoid missing potential symptoms.

No MeSH data available.


Related in: MedlinePlus

Cutaneous-melanoma patient Lübeck (CMPL) serum levels of CD163 (Cluster of Differentiation 163). Results were normalized to the non-melanoma control (NMC). This specific cutaneous melanoma patient, who was affected by rapid metastatic disease, showed significant elevated levels of CD163. *Signifies p < 0.05 (unpaired Student t test)
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Fig4: Cutaneous-melanoma patient Lübeck (CMPL) serum levels of CD163 (Cluster of Differentiation 163). Results were normalized to the non-melanoma control (NMC). This specific cutaneous melanoma patient, who was affected by rapid metastatic disease, showed significant elevated levels of CD163. *Signifies p < 0.05 (unpaired Student t test)

Mentions: Multiplex ELISA showed a significant elevated serum level of CD163 in CMPL compared to NMC (Fig. 4). All other cytokines were not significantly different.Fig. 4


Introducing MARCo: Histoserological Findings of a Multi-Organic Paraneoplastic Syndrome in Cutaneous Melanoma Patients
Cutaneous-melanoma patient Lübeck (CMPL) serum levels of CD163 (Cluster of Differentiation 163). Results were normalized to the non-melanoma control (NMC). This specific cutaneous melanoma patient, who was affected by rapid metastatic disease, showed significant elevated levels of CD163. *Signifies p < 0.05 (unpaired Student t test)
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5120631&req=5

Fig4: Cutaneous-melanoma patient Lübeck (CMPL) serum levels of CD163 (Cluster of Differentiation 163). Results were normalized to the non-melanoma control (NMC). This specific cutaneous melanoma patient, who was affected by rapid metastatic disease, showed significant elevated levels of CD163. *Signifies p < 0.05 (unpaired Student t test)
Mentions: Multiplex ELISA showed a significant elevated serum level of CD163 in CMPL compared to NMC (Fig. 4). All other cytokines were not significantly different.Fig. 4

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Cutaneous melanoma (CM) is an aggressive skin cancer entity, causing most skin cancer-related deaths. Autoimmune disorders have been described as potential paraneoplastic complications. The purpose of this study was to elucidate the possibility of a combinatory paraneoplastic affection of the retina and cochlea in patients with CM.

Methods: Sera samples from CM patients were used for indirect immunofluorescence on histological retinal and cochlear sections. Furthermore, the serum specimen of a patient with symptomatic affection of both organs was analyzed by multiplex ELISA (enzyme-linked immunosorbent assay) for various cytokines including CD163 (cluster of differentiation 163).

Results: Eleven patients were diagnosed with CM. Autoantibodies against structures of the inner ear were confirmed in all patients who were tested positive for antiretinal antibodies as well. CD163 was significantly elevated in the double-symptomatic patient, who developed metastatic disease.

Conclusion: Paraneoplastic disease of CM can affect more than one organ and this affect may be correlated with the individual prognosis. Therefore, a thorough anamnesis is needed to avoid missing potential symptoms.

No MeSH data available.


Related in: MedlinePlus