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Introducing MARCo: Histoserological Findings of a Multi-Organic Paraneoplastic Syndrome in Cutaneous Melanoma Patients

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ABSTRACT

Introduction: Cutaneous melanoma (CM) is an aggressive skin cancer entity, causing most skin cancer-related deaths. Autoimmune disorders have been described as potential paraneoplastic complications. The purpose of this study was to elucidate the possibility of a combinatory paraneoplastic affection of the retina and cochlea in patients with CM.

Methods: Sera samples from CM patients were used for indirect immunofluorescence on histological retinal and cochlear sections. Furthermore, the serum specimen of a patient with symptomatic affection of both organs was analyzed by multiplex ELISA (enzyme-linked immunosorbent assay) for various cytokines including CD163 (cluster of differentiation 163).

Results: Eleven patients were diagnosed with CM. Autoantibodies against structures of the inner ear were confirmed in all patients who were tested positive for antiretinal antibodies as well. CD163 was significantly elevated in the double-symptomatic patient, who developed metastatic disease.

Conclusion: Paraneoplastic disease of CM can affect more than one organ and this affect may be correlated with the individual prognosis. Therefore, a thorough anamnesis is needed to avoid missing potential symptoms.

No MeSH data available.


Related in: MedlinePlus

Characteristic electrophysiological findings in melanoma-associated retinopathy (MAR). a Scotopic (rod responses) full-field electroretinogram (ERG): Negative ERG with missing b-waves on the right eye and normal responses on the left one. b Photopic (cone responses) full-field ERG: Negative ERG with missing b-waves on both eyes, however, this was more pronounced on the right eye
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Fig1: Characteristic electrophysiological findings in melanoma-associated retinopathy (MAR). a Scotopic (rod responses) full-field electroretinogram (ERG): Negative ERG with missing b-waves on the right eye and normal responses on the left one. b Photopic (cone responses) full-field ERG: Negative ERG with missing b-waves on both eyes, however, this was more pronounced on the right eye

Mentions: In most cases, symptoms correlated with electrophysiological findings like for CMPL. In this specific case, the patient was previously diagnosed with two episodes of CM. While fundoscopic examination did not show any pathological changes, the ERG demonstrated a significant b-wave reduction, particularly of the right eye (Fig. 1).Fig. 1


Introducing MARCo: Histoserological Findings of a Multi-Organic Paraneoplastic Syndrome in Cutaneous Melanoma Patients
Characteristic electrophysiological findings in melanoma-associated retinopathy (MAR). a Scotopic (rod responses) full-field electroretinogram (ERG): Negative ERG with missing b-waves on the right eye and normal responses on the left one. b Photopic (cone responses) full-field ERG: Negative ERG with missing b-waves on both eyes, however, this was more pronounced on the right eye
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5120631&req=5

Fig1: Characteristic electrophysiological findings in melanoma-associated retinopathy (MAR). a Scotopic (rod responses) full-field electroretinogram (ERG): Negative ERG with missing b-waves on the right eye and normal responses on the left one. b Photopic (cone responses) full-field ERG: Negative ERG with missing b-waves on both eyes, however, this was more pronounced on the right eye
Mentions: In most cases, symptoms correlated with electrophysiological findings like for CMPL. In this specific case, the patient was previously diagnosed with two episodes of CM. While fundoscopic examination did not show any pathological changes, the ERG demonstrated a significant b-wave reduction, particularly of the right eye (Fig. 1).Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Cutaneous melanoma (CM) is an aggressive skin cancer entity, causing most skin cancer-related deaths. Autoimmune disorders have been described as potential paraneoplastic complications. The purpose of this study was to elucidate the possibility of a combinatory paraneoplastic affection of the retina and cochlea in patients with CM.

Methods: Sera samples from CM patients were used for indirect immunofluorescence on histological retinal and cochlear sections. Furthermore, the serum specimen of a patient with symptomatic affection of both organs was analyzed by multiplex ELISA (enzyme-linked immunosorbent assay) for various cytokines including CD163 (cluster of differentiation 163).

Results: Eleven patients were diagnosed with CM. Autoantibodies against structures of the inner ear were confirmed in all patients who were tested positive for antiretinal antibodies as well. CD163 was significantly elevated in the double-symptomatic patient, who developed metastatic disease.

Conclusion: Paraneoplastic disease of CM can affect more than one organ and this affect may be correlated with the individual prognosis. Therefore, a thorough anamnesis is needed to avoid missing potential symptoms.

No MeSH data available.


Related in: MedlinePlus