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Systolic blood pressure values might further risk-stratify the adverse outcomes of LVH in older patients with chronic kidney disease

View Article: PubMed Central - PubMed

ABSTRACT

Background: LVH is highly prevalent in patients with CKD and is independently associated with subsequent cardiovascular events.

Background: We hypothesized that adding systolic blood pressure values to LVH might differentiate different subgroups of patients at higher risk of cardiovascular events (CVE) and other adverse outcomes.

Methods: Retrospective cohort study of 243 patients older than 60 years with stages 1-5 pre-dialysis CKD. LVH was assessed by electrocardiogram or echocardiogram.

Results: Cardiovascular events occurred in 7 patients (10.3%) among those with SBP <130 and no LVH, 8 patients (10.5%) among those with SBP ≥130 and no LVH, 7 patients (21.2%) among those with SBP <130 and LVH and 25 patients (37.9%) among those with SBP ≥ 130 and LVH.

Results: On multivariate analyses, comparing to SBP < 130 and no LVH, the HR for CVE in those with SBP ≥ 130 and LVH was 4 (1.75, 10.3), p = 0.0007; 2.13 (0.71, 6.32) p = 0.16 in those with SBP <130 and LVH and 1.20 (0.42, 3.51) p = 0.72 in those with SBP ≥130 and no LVH.

Results: No significant differences were noted in changes in renal function and mortality rates among the groups.

Conclusion: The combination of higher systolic blood pressure and LVH might identify older patients with CKD at higher risk of cardiovascular outcomes.

No MeSH data available.


Kaplan-Meier analyses of cardiovascular event-free survival according to LVH and SBP
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Fig1: Kaplan-Meier analyses of cardiovascular event-free survival according to LVH and SBP

Mentions: Primary and secondary outcomes are reported in Table 2. During the follow up period (median 2.5 years, range 0.02-2.8) there were 47 cardiovascular events and 13 deaths. The incidence of cardiovascular events was higher in those patients with LVH, especially in those with a SBP ≥130 mmHg (Fig. 1).Table 2


Systolic blood pressure values might further risk-stratify the adverse outcomes of LVH in older patients with chronic kidney disease
Kaplan-Meier analyses of cardiovascular event-free survival according to LVH and SBP
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5120495&req=5

Fig1: Kaplan-Meier analyses of cardiovascular event-free survival according to LVH and SBP
Mentions: Primary and secondary outcomes are reported in Table 2. During the follow up period (median 2.5 years, range 0.02-2.8) there were 47 cardiovascular events and 13 deaths. The incidence of cardiovascular events was higher in those patients with LVH, especially in those with a SBP ≥130 mmHg (Fig. 1).Table 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: LVH is highly prevalent in patients with CKD and is independently associated with subsequent cardiovascular events.

Background: We hypothesized that adding systolic blood pressure values to LVH might differentiate different subgroups of patients at higher risk of cardiovascular events (CVE) and other adverse outcomes.

Methods: Retrospective cohort study of 243 patients older than 60 years with stages 1-5 pre-dialysis CKD. LVH was assessed by electrocardiogram or echocardiogram.

Results: Cardiovascular events occurred in 7 patients (10.3%) among those with SBP <130 and no LVH, 8 patients (10.5%) among those with SBP ≥130 and no LVH, 7 patients (21.2%) among those with SBP <130 and LVH and 25 patients (37.9%) among those with SBP ≥ 130 and LVH.

Results: On multivariate analyses, comparing to SBP < 130 and no LVH, the HR for CVE in those with SBP ≥ 130 and LVH was 4 (1.75, 10.3), p = 0.0007; 2.13 (0.71, 6.32) p = 0.16 in those with SBP <130 and LVH and 1.20 (0.42, 3.51) p = 0.72 in those with SBP ≥130 and no LVH.

Results: No significant differences were noted in changes in renal function and mortality rates among the groups.

Conclusion: The combination of higher systolic blood pressure and LVH might identify older patients with CKD at higher risk of cardiovascular outcomes.

No MeSH data available.