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Geographical predisposition influences on the distribution and tissue characterisation of eccentric coronary plaques in non-branching coronary arteries: cross-sectional study of coronary plaques analysed by intravascular ultrasound

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ABSTRACT

Background: We investigated the influence of geographical predisposition on the spatial distribution and composition of coronary plaques.

Methods: Thirty coronary arteries were evaluated. A total of 1441 cross-sections were collected from intravascular ultrasound (IVUS) and radio-frequency signal-based virtual histology (VH-IVUS) imaging. To exclude complex geographical effects of side branches and to localise the plaque distribution, we analysed only eccentric plaques in non-branching regions. The spatial distribution of eccentric plaques in the coronary artery was classified into myocardial, lateral, and epicardial regions. The composition of eccentric plaques was analysed using VH-IVUS.

Results: The plaque was concentric in 723 sections (50.2%) and eccentric in 718 (49.9%). Eccentric plaques were more frequently distributed towards the myocardial side than towards the epicardial side (46.7 ± 7.5% vs. 12.5 ± 4.2%, p = 0.003). No significant difference was observed between the myocardial and lateral sides (46.7 ± 7.5% vs. 20.8 ± 5.0%) or between the lateral and epicardial sides. Eccentric thin-capped fibroatheromas were more frequently distributed towards the myocardial side than towards the lateral side (p = 0.024) or epicardial side (p = 0.005).

Conclusion: Geographical predisposition is associated with distribution, tissue characterisation, and vulnerability of plaques in non-branching coronary arteries.

No MeSH data available.


Related in: MedlinePlus

Distribution of thin-capped fibroatheromas (TCFAs). Of the total TCFAs, 4.19 ± 1.49% were distributed towards the myocardial side, 0.80 ± 0.77% towards the lateral side, and none towards the epicardial side. Data are shown as mean ± SEM. N.S., not significant
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Fig3: Distribution of thin-capped fibroatheromas (TCFAs). Of the total TCFAs, 4.19 ± 1.49% were distributed towards the myocardial side, 0.80 ± 0.77% towards the lateral side, and none towards the epicardial side. Data are shown as mean ± SEM. N.S., not significant

Mentions: We observed TCFAs significantly more frequently in myocardial side plaques (4.99 ± 1.61%) than in lateral side plaques (0.80 ± 0.77%, p = 0.024) or in epicardial side plaques (0%, p = 0.005) (Fig. 3).Fig. 3


Geographical predisposition influences on the distribution and tissue characterisation of eccentric coronary plaques in non-branching coronary arteries: cross-sectional study of coronary plaques analysed by intravascular ultrasound
Distribution of thin-capped fibroatheromas (TCFAs). Of the total TCFAs, 4.19 ± 1.49% were distributed towards the myocardial side, 0.80 ± 0.77% towards the lateral side, and none towards the epicardial side. Data are shown as mean ± SEM. N.S., not significant
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Related In: Results  -  Collection

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Fig3: Distribution of thin-capped fibroatheromas (TCFAs). Of the total TCFAs, 4.19 ± 1.49% were distributed towards the myocardial side, 0.80 ± 0.77% towards the lateral side, and none towards the epicardial side. Data are shown as mean ± SEM. N.S., not significant
Mentions: We observed TCFAs significantly more frequently in myocardial side plaques (4.99 ± 1.61%) than in lateral side plaques (0.80 ± 0.77%, p = 0.024) or in epicardial side plaques (0%, p = 0.005) (Fig. 3).Fig. 3

View Article: PubMed Central - PubMed

ABSTRACT

Background: We investigated the influence of geographical predisposition on the spatial distribution and composition of coronary plaques.

Methods: Thirty coronary arteries were evaluated. A total of 1441 cross-sections were collected from intravascular ultrasound (IVUS) and radio-frequency signal-based virtual histology (VH-IVUS) imaging. To exclude complex geographical effects of side branches and to localise the plaque distribution, we analysed only eccentric plaques in non-branching regions. The spatial distribution of eccentric plaques in the coronary artery was classified into myocardial, lateral, and epicardial regions. The composition of eccentric plaques was analysed using VH-IVUS.

Results: The plaque was concentric in 723 sections (50.2%) and eccentric in 718 (49.9%). Eccentric plaques were more frequently distributed towards the myocardial side than towards the epicardial side (46.7 ± 7.5% vs. 12.5 ± 4.2%, p = 0.003). No significant difference was observed between the myocardial and lateral sides (46.7 ± 7.5% vs. 20.8 ± 5.0%) or between the lateral and epicardial sides. Eccentric thin-capped fibroatheromas were more frequently distributed towards the myocardial side than towards the lateral side (p = 0.024) or epicardial side (p = 0.005).

Conclusion: Geographical predisposition is associated with distribution, tissue characterisation, and vulnerability of plaques in non-branching coronary arteries.

No MeSH data available.


Related in: MedlinePlus