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Symmetrical acrokeratoderma: a case series in Indian patients

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ABSTRACT

Abstract: Symmetrical acrokeratoderma is a recently described dermatosis in young adult males of Chinese descent. In this report, we describe a series of five cases of symmetrical acrokeratoderma from India. All 5 patients had asymptomatic, brownish-black plaques distributed symmetrically over dorsum of hand and feet with variable involvement of wrist, flexural surface of forearm, elbow, ankles, shin and knee joint. Palms and soles were characteristically spared. Typically whitish maceration of the lesions was seen after immersing in water. The disease showed exacerbation in hot and humid climate with spontaneous resolution in winter. Histopathological examination showed basket weave hyperkeratosis, irregular acanthosis and mild peri-vascular lymphomononuclear infiltrate. Loosening of the stratum corneum was seen in post-immersion biopsy specimens. Acitretin appeared to provide symptomatic improvement in the short term without any long-term effect on the natural disease course. The genetic and environmental factors involved in disease causation needs to be elucidated in future.

Trial registration: The study was not registered in a trial registry since it was a retrospective analysis of the clinical records and not an interventional/observational study.

No MeSH data available.


Related in: MedlinePlus

a Microphotograph of symmetrical acrokeratoderma showing basket weave orthokeratosis, irregular acanthosis and mild perivascular lymphocytic infiltrate (H&E, 100X). b Microphotograph of post-immersion skin biopsy showing loosening of the stratum corneum (H&E, 100X)
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Fig2: a Microphotograph of symmetrical acrokeratoderma showing basket weave orthokeratosis, irregular acanthosis and mild perivascular lymphocytic infiltrate (H&E, 100X). b Microphotograph of post-immersion skin biopsy showing loosening of the stratum corneum (H&E, 100X)

Mentions: Histopathological examination consistently showed basket weave hyperkeratosis, normal granular layer and irregular acanthosis (Fig. 2a). Increased pigmentation at papillary tips was noted in three patients. Histopathological analysis of the post-immersion specimen showed loosening of the stratum corneum (Fig. 2b). No fungal elements were seen in any of the biopsy specimens.Fig. 2


Symmetrical acrokeratoderma: a case series in Indian patients
a Microphotograph of symmetrical acrokeratoderma showing basket weave orthokeratosis, irregular acanthosis and mild perivascular lymphocytic infiltrate (H&E, 100X). b Microphotograph of post-immersion skin biopsy showing loosening of the stratum corneum (H&E, 100X)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5120419&req=5

Fig2: a Microphotograph of symmetrical acrokeratoderma showing basket weave orthokeratosis, irregular acanthosis and mild perivascular lymphocytic infiltrate (H&E, 100X). b Microphotograph of post-immersion skin biopsy showing loosening of the stratum corneum (H&E, 100X)
Mentions: Histopathological examination consistently showed basket weave hyperkeratosis, normal granular layer and irregular acanthosis (Fig. 2a). Increased pigmentation at papillary tips was noted in three patients. Histopathological analysis of the post-immersion specimen showed loosening of the stratum corneum (Fig. 2b). No fungal elements were seen in any of the biopsy specimens.Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Abstract: Symmetrical acrokeratoderma is a recently described dermatosis in young adult males of Chinese descent. In this report, we describe a series of five cases of symmetrical acrokeratoderma from India. All 5 patients had asymptomatic, brownish-black plaques distributed symmetrically over dorsum of hand and feet with variable involvement of wrist, flexural surface of forearm, elbow, ankles, shin and knee joint. Palms and soles were characteristically spared. Typically whitish maceration of the lesions was seen after immersing in water. The disease showed exacerbation in hot and humid climate with spontaneous resolution in winter. Histopathological examination showed basket weave hyperkeratosis, irregular acanthosis and mild peri-vascular lymphomononuclear infiltrate. Loosening of the stratum corneum was seen in post-immersion biopsy specimens. Acitretin appeared to provide symptomatic improvement in the short term without any long-term effect on the natural disease course. The genetic and environmental factors involved in disease causation needs to be elucidated in future.

Trial registration: The study was not registered in a trial registry since it was a retrospective analysis of the clinical records and not an interventional/observational study.

No MeSH data available.


Related in: MedlinePlus