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The Effect of BCAA and ISO-WHEY Oral Nutritional Supplements on Dialysis Adequacy

View Article: PubMed Central - PubMed

ABSTRACT

Background: Protein-energy malnutrition is a common problem in hemodialysis patients and has different outcomes such as reduced quality of life, longer hospitalization time, lower dialysis adequacy, and higher mortality rate. Investigation of dialysis adequacy is an important method for assessing hemodialysis patients, and improving the dialysis adequacy is an important healthcare team goal.

Objectives: The present study aims to investigate and compare the effects of BCAA and ISO-WHEY oral nutritional supplements on dialysis adequacy.

Methods: In a clinical trial study, 66 hemodialysis patients were randomly divided into three groups: Group A (n = 22), Group B (n = 22), and Group C or the control group (n = 22). In Groups A and B, as prescribed and controlled by nutritionists and nephrologists, respectively, ISO-WHEY and BCAA protein powder were used for 2 months on a daily basis. For all groups, before intervention and 1 and 2 months after intervention, the dialysis adequacy was measured using URR and Kt/V. Finally, the data were analyzed using IBM SPSS Statistics Base 21.0 software.

Results: Out of 66 patients, 61 (19 in Group A, 20 in Group B, and 22 in Group C) completed the study period, and before intervention, all groups were equal in terms of quality and quantity variables (P > 0.05). After intervention, there was a significant difference between the three groups with regard to the variables of dialysis adequacy based on Kt/V and URR to independent-t test and repeated measures ANOVA (P < 0.05).

Conclusions: Results show that the intake of oral nutritional supplements leads to an improvement in the dialysis adequacy of hemodialysis patients. Therefore, the use of nutritional supplements along with patients' training and regular consultation will be helpful in improving the nutritional status, dialysis adequacy, and eventually the quality of life.

No MeSH data available.


Average Changes in the Dialysis Adequacy Based on Kt/V in Different Measurement Steps
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fig37898: Average Changes in the Dialysis Adequacy Based on Kt/V in Different Measurement Steps

Mentions: There was no significant difference between the three groups based on Kt/V and URR in the first step (before intervention) (P > 0.05). Therefore, the groups were homogenous in this step. However, there was a significant difference between the groups in the second step (1 month after intervention) and the third step (2 months after intervention) (P < 0.05) (Table 3). Moreover, repeated measures ANOVA showed a significant statistical difference in the average changes in dialysis adequacy based on Kt/V and URR among the three groups (Figures 1 and 2). The post-hoc test showed that the difference between these three groups is because of the ISO-WHEY and control groups.


The Effect of BCAA and ISO-WHEY Oral Nutritional Supplements on Dialysis Adequacy
Average Changes in the Dialysis Adequacy Based on Kt/V in Different Measurement Steps
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120366&req=5

fig37898: Average Changes in the Dialysis Adequacy Based on Kt/V in Different Measurement Steps
Mentions: There was no significant difference between the three groups based on Kt/V and URR in the first step (before intervention) (P > 0.05). Therefore, the groups were homogenous in this step. However, there was a significant difference between the groups in the second step (1 month after intervention) and the third step (2 months after intervention) (P < 0.05) (Table 3). Moreover, repeated measures ANOVA showed a significant statistical difference in the average changes in dialysis adequacy based on Kt/V and URR among the three groups (Figures 1 and 2). The post-hoc test showed that the difference between these three groups is because of the ISO-WHEY and control groups.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Protein-energy malnutrition is a common problem in hemodialysis patients and has different outcomes such as reduced quality of life, longer hospitalization time, lower dialysis adequacy, and higher mortality rate. Investigation of dialysis adequacy is an important method for assessing hemodialysis patients, and improving the dialysis adequacy is an important healthcare team goal.

Objectives: The present study aims to investigate and compare the effects of BCAA and ISO-WHEY oral nutritional supplements on dialysis adequacy.

Methods: In a clinical trial study, 66 hemodialysis patients were randomly divided into three groups: Group A (n = 22), Group B (n = 22), and Group C or the control group (n = 22). In Groups A and B, as prescribed and controlled by nutritionists and nephrologists, respectively, ISO-WHEY and BCAA protein powder were used for 2 months on a daily basis. For all groups, before intervention and 1 and 2 months after intervention, the dialysis adequacy was measured using URR and Kt/V. Finally, the data were analyzed using IBM SPSS Statistics Base 21.0 software.

Results: Out of 66 patients, 61 (19 in Group A, 20 in Group B, and 22 in Group C) completed the study period, and before intervention, all groups were equal in terms of quality and quantity variables (P &gt; 0.05). After intervention, there was a significant difference between the three groups with regard to the variables of dialysis adequacy based on Kt/V and URR to independent-t test and repeated measures ANOVA (P &lt; 0.05).

Conclusions: Results show that the intake of oral nutritional supplements leads to an improvement in the dialysis adequacy of hemodialysis patients. Therefore, the use of nutritional supplements along with patients' training and regular consultation will be helpful in improving the nutritional status, dialysis adequacy, and eventually the quality of life.

No MeSH data available.