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Allostasis in health and food addiction

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ABSTRACT

Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group. Correlation analyses were performed on behavioral data, and correlation, comparative and conjunction analyses were performed to extract electrophysiological relationships between pleasure, salience, allostasis and withdrawal. Pleasure/liking seems to be the phenomenological expression that enough salient stimuli are obtained, and withdrawal can be seen as a motivational incentive because due to allostatic reference resetting, more stimuli are required. In addition, in contrast to non-addiction, a pathological, non-adaptive salience attached to food results in withdrawal mediated through persistent allostatic reference resetting.

No MeSH data available.


For the gamma frequency band, a comparison between the addicted group and the control group shows a significant increased connectivity (the log of F-ratio‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the addicted group.
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f7: For the gamma frequency band, a comparison between the addicted group and the control group shows a significant increased connectivity (the log of F-ratio‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the addicted group.

Mentions: Significantly increased connectivity (F‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) was identified between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the gamma frequency band for the High YFAS group compared to the control group (see Fig. 7). No significant effect was identified for delta, theta, alpha1, alpha2, beta1, beta2 or beta3 frequency bands.


Allostasis in health and food addiction
For the gamma frequency band, a comparison between the addicted group and the control group shows a significant increased connectivity (the log of F-ratio‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the addicted group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120365&req=5

f7: For the gamma frequency band, a comparison between the addicted group and the control group shows a significant increased connectivity (the log of F-ratio‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the addicted group.
Mentions: Significantly increased connectivity (F‚ÄČ=‚ÄČ1.76, p‚ÄČ<‚ÄČ0.05) was identified between the pregenual anterior cingulate cortex, dorsal anterior cingulate cortex and the posterior cingulate cortex for the gamma frequency band for the High YFAS group compared to the control group (see Fig. 7). No significant effect was identified for delta, theta, alpha1, alpha2, beta1, beta2 or beta3 frequency bands.

View Article: PubMed Central - PubMed

ABSTRACT

Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group. Correlation analyses were performed on behavioral data, and correlation, comparative and conjunction analyses were performed to extract electrophysiological relationships between pleasure, salience, allostasis and withdrawal. Pleasure/liking seems to be the phenomenological expression that enough salient stimuli are obtained, and withdrawal can be seen as a motivational incentive because due to allostatic reference resetting, more stimuli are required. In addition, in contrast to non-addiction, a pathological, non-adaptive salience attached to food results in withdrawal mediated through persistent allostatic reference resetting.

No MeSH data available.