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Allostasis in health and food addiction

View Article: PubMed Central - PubMed

ABSTRACT

Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group. Correlation analyses were performed on behavioral data, and correlation, comparative and conjunction analyses were performed to extract electrophysiological relationships between pleasure, salience, allostasis and withdrawal. Pleasure/liking seems to be the phenomenological expression that enough salient stimuli are obtained, and withdrawal can be seen as a motivational incentive because due to allostatic reference resetting, more stimuli are required. In addition, in contrast to non-addiction, a pathological, non-adaptive salience attached to food results in withdrawal mediated through persistent allostatic reference resetting.

No MeSH data available.


A conjunction analysis for the High YFAS participants between salience and allostasis demonstrates shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 band.In addition, for the theta frequency band shared activity was identified in the superior parietal lobe. For the gamma band shared activity is noted in the PCC bilaterally as well as in the left VLPFC, insula and anterior temporal pole (lower right quadrant of Fig. 5).
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f6: A conjunction analysis for the High YFAS participants between salience and allostasis demonstrates shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 band.In addition, for the theta frequency band shared activity was identified in the superior parietal lobe. For the gamma band shared activity is noted in the PCC bilaterally as well as in the left VLPFC, insula and anterior temporal pole (lower right quadrant of Fig. 5).

Mentions: A conjunction analysis for the High YFAS participants between salience and allostasis demonstrated shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 bands (Fig. 6). In addition, for the theta frequency band, shared activity was identified in the superior parietal lobe. For the gamma band, shared activity was noted in the posterior cingulate cortex bilaterally as well as in the left ventral lateral prefrontal cortex, insula and anterior temporal pole (lower right quadrant of Fig. 6). No effect was identified for the delta, alpha2, beta1, or beta2 frequency bands.


Allostasis in health and food addiction
A conjunction analysis for the High YFAS participants between salience and allostasis demonstrates shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 band.In addition, for the theta frequency band shared activity was identified in the superior parietal lobe. For the gamma band shared activity is noted in the PCC bilaterally as well as in the left VLPFC, insula and anterior temporal pole (lower right quadrant of Fig. 5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120365&req=5

f6: A conjunction analysis for the High YFAS participants between salience and allostasis demonstrates shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 band.In addition, for the theta frequency band shared activity was identified in the superior parietal lobe. For the gamma band shared activity is noted in the PCC bilaterally as well as in the left VLPFC, insula and anterior temporal pole (lower right quadrant of Fig. 5).
Mentions: A conjunction analysis for the High YFAS participants between salience and allostasis demonstrated shared activity in the posterior cingulate cortex extending to the precuneus for the delta, theta, and alpha1 bands (Fig. 6). In addition, for the theta frequency band, shared activity was identified in the superior parietal lobe. For the gamma band, shared activity was noted in the posterior cingulate cortex bilaterally as well as in the left ventral lateral prefrontal cortex, insula and anterior temporal pole (lower right quadrant of Fig. 6). No effect was identified for the delta, alpha2, beta1, or beta2 frequency bands.

View Article: PubMed Central - PubMed

ABSTRACT

Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group. Correlation analyses were performed on behavioral data, and correlation, comparative and conjunction analyses were performed to extract electrophysiological relationships between pleasure, salience, allostasis and withdrawal. Pleasure/liking seems to be the phenomenological expression that enough salient stimuli are obtained, and withdrawal can be seen as a motivational incentive because due to allostatic reference resetting, more stimuli are required. In addition, in contrast to non-addiction, a pathological, non-adaptive salience attached to food results in withdrawal mediated through persistent allostatic reference resetting.

No MeSH data available.